Abstract
The purpose of the study was to identify multiple organ pathologies in rats with experimental alloxan diabetes. The work shows that intraperitoneal administration of alloxan to Wistar rats (n=80), at a dose of 150 mg/kg of animal body weight, leads after 30 days to morphological changes in parenchymal organs. The combined pathology is determined by the etiological factor and toxic products of the altered organism of rats, the causal links of which are: destruction of B cells with lymphocytic infiltration of the islets of Langerhans, insulin deficiency, hyperglycemia, qualitative changes in intracellular proteins and enzyme activity, swelling of organelles and an increase in the volume of the cell as a whole, intra- and extracellular changes in electrolyte content. Consequently, insulin is a moderator in the regulation of the metabolism of many cells, and in its long-term absence, typical pathological processes in organs and tissues stereotypically arise.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
