Возможности повышения эффективности комплексного лечения оптического неврита герпесвирусной этиологии

Abstract

Purpose. Evaluation of morphofunctional and laboratory-immunological results of the use of immunotherapy in the complex treatment of optic neuritis (ON) associated with herpesvirus infection (HVI). Material and methods. 39 people (39 eyes) with acute ON associated with HVI. The treatment regimen included the appointment of a dexamethasone solution according to a decreasing scheme, a 1 % solution of the drug «Emoxipin» 0.5 ml and a 12.5 % solution of the drug «Dicynone» 0.5 ml through an irrigation system implanted in the retrobulbar space, in combination with the prescription of drugs neuroprotection («Pikamilon» and «Semax») for 10 days. All patients were divided into 2 groups. The main group – 22 patients, in the treatment regimen of which the drug «Imunofan» was added. The control group included 17 patients who received standard treatment. Immunotherapy was carried out for 10–12 days. Results. Data analysis showed that the most significant positive dynamics was noted in patients of the main group. Conclusion. The clinical efficacy of the drug «Imunofan» in the complex therapy of ON associated with HVI was characterized by a reduction in the time for relief of signs of inflammation in the optic nerve by 2 times or more, an increase in the maximum corrected visual acuity by 4.5 times, a decrease in the incidence of relapses of ON by 2 times with follow-up period of 12 months. Keywords: optic neuritis, herpesvirus infection, corticosteroid therapy, immunotherapy