Возможности терапии острого оптического неврита, ассоциированного с герпесвирусной инфекцией

Abstract

Purpose. To study the clinical efficacy of complex treatment of optic neuritis (ON) associated with herpesvirus infection (HVI), including immunotherapy methods. Material and methods. The study included 37 people (37 eyes) with acute ON associated with HVI. The scheme of treatment of patients included the supply of solutions to the optic nerve: dexamethasone in a decreasing pattern, Emoxypin 1 % 0.5 ml and Dicinon 12.5 % 0.5 ml through an irrigation system implanted in the retrobulbar space, in combination with the appointment neuroprotection drugs (Pikamilon and Semax) for 10 days. All patients were divided into 2 groups. The 1st group consisted of 17 patients who were treated only according to the method described above. The 2nd group consisted of 20 patients who additionally received Imunofan intramuscularly in the regimen and doses according to the manufacturer's instructions. Immunotherapy was carried out for 10–12 days. Results. Data analysis showed that the most significant positive dynamics was observed in patients of the 2nd group. Conclusion. The developed scheme of etiotropic and pathogenetic immunotherapy for herpesvirus ON allows to reduce the recovery time and improve the functional results of treatment in the absence of recurrence of the disease within 1 year of observation. Keywords: optic neuritis, herpes virus infection, corticosteroid therapy, immunotherapy