Abstract
The purpose of this study was to investigate the effect on energy expenditure and energy substrate utilization for 24 hours in an osteoarthritis model. In the MIA group, arthritis was induced for 2 weeks by injecting MIA into the joint cavity of the knee, followed by foot print evaluation. In addition, energy expenditure and energy substrate utilization were measured for 24 hours in metabolic chamber. As a result of this study, first, the osteoarthritis model showed lower footprint intensity than the control group due to pain and gait problems during foot evaluation (p<.001). Second, the osteoarthritis model showed lower oxygen uptake and energy expenditure than the control group (p<.01, p<.05). Third, the osteoarthritis model showed higher carbohydrate oxidation and lower fat oxidation compared to the control group (p<.05, p<.01). In conclusion, it was shown that osteoarthritis induction reduces overall activity and thus reduces total energy expenditure, and the energy substrate used at this time is mainly carbohydrate, which is thought to be the result of the cell's recovery and production mechanism.
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