Abstract
The article discusses the issues of diagnosing autoimmune hepatitis and the importance of timely liver biopsy with histological examination. Due to the lack of specific diagnostic markers and vast heterogeneity of clinical, laboratory and histological features, and also considering relatively rare incidence of the disease, the diagnosis of autoimmune hepatitis can be difficult. Therefore, this review summarises the etiopathogenesis, clinical, serological and histological manifestations of autoimmune hepatitis. Special attention is paid to the different specificity of morphological features such as portal hepatitis, centrilobular necroses, rosette formation, emperipolesis and their significance depending on the presence of laboratory signs of autoimmune hepatitis. Visual examples of morphological manifestations are presented. The article also emphasises the importance of a comprehensive approach to signs and symptoms for the detection of autoimmune hepatitis and differential diagnosis with other liver pathologies: viral hepatitis, drug-induced liver injury, primary cholangitis, and Wilson's disease. Consideration of all available data is crucial in the diagnosis of autoimmune hepatitis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
