ПАТОГЕНЕТИЧЕСКИЕ ПОДХОДЫ К ТЕРАПИИ ПРИ ЭКСПЕРИМЕНТАЛЬНЫХ ИНФИЦИРОВАННЫХ РАНАХ У КОШЕК

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Wound pathology is one of the most important problems of modern veterinary surgery. Violation of connective tissue metabolism significantly affects the occurrence and development of many pathological processes in various organs and tissues, but the indicators of connective tissue metabolism in purulent wounds in cats have not been studied enough. Therefore, their study will allow pathogenetically substantiate and improve the methods of treatment of purulent wounds in cats. In animals of the experimental group who were treated with methyluracil with miramistin with the addition of 1% hyaluronic acid and 1% trifuzol, an increase in the content of hexoses associated with proteins, hexoses of glycoproteins and sialic acids was recorded only during the period of inflammatory and degenerative changes. In the future, starting from the twelve days of the experiment, these indicators decreased to the initial level. In animals of the control group during treatment, the content of hexoses associated with proteins gradually decreased, but was higher than in cats of the experimental group due to an increase in the proportion of hexoses of glycosaminglicans. Also in the control group, the content of sialic acids remained high throughout the experiment. This trend indicates that the use of ointment with the addition of hyaluronic acid and trifuzol contributes to the normalization of the G-GAG / G-GP index, which is characteristic of a more intensive development of reparative processes. On the contrary, an increase in the healing time of a wound defect in animals of the control group was accompanied by a redistribution of hexose fractions towards an increase in the proportion of glycosaminglicans. These changes are due to the gradual depolymerization and restructuring of the main substance of the connective tissue in the phase of regeneration and proliferation of the wound process.