Изменения иридо-хрусталиковой диафрагмы на фоне трех загрузочных интравитреальных инъекций anti-VEGF препарата

Abstract

Purpose. To use anterior segment optical coherence tomography (AS-OCT) to evaluate the lens-iris diaphragm after intravitreal injections (IVI) of anti-vascular endothelial growth factor (anti-VEGF). Material and methods. Twenty patients scheduled for IVI of anti-VEGF for the treatment of neovascular age-related macular degeneration (NVAMD) were enrolled in this study. All patients underwent a standard ophthalmological examination and AS-OCT. Intraocular pressure (IOP) was measured before IVI, after 1 minute, 30 minutes and after 3 hours. Results. The average thickness of the lens was 5.65 ± 0.7 mm. The mean anterior chamber (AC) depth before IVI was 2.584 ± 0.33 mm, one month after the 1 st IVI was 2.563 ± 0.34 mm, one month after the 3 rd IVI was 2.543 ± 0.34 mm; there was a significant decrease in the size of the AC depth after three injections by an average of 0.0409 ± 0.03 mm (p < 0.05), and a lower AC depth was associated with a greater rise in IOP immediately after the injection ( = 0,412, p < 0,05). There is significant narrowing of the temporal and nasal anterior chamber angle in the meridian 0–180° before the treatment and one month after three loading doses (p < 0,05). Conclusions. After three loading IVI, there are significant changes in the lens-iris diaphragm were observed in patients with NVAMD according to AS-OCT data. It is necessary to analyse long-term results in a larger sample of patients to further study the mechanisms of increased IOP after IVI. Keywords: anti-VEGF drugs, intravitreal injection, intraocular pressure, lens-iris diaphragm.