Антропометрические характеристики и особенности системного воспалительного ответа у пациенток с эндометриозом

Abstract

Abstract Aim. To assess the relationship between cytokine levels and body mass index (BMI) in women with ovarian endometriomas. Design. A prospective cohort study. Materials and methods. The study included 46 women referred for surgical treatment (laparoscopy, cystectomy) due to ovarian endometriomas. Peritoneal fluid in a volume of 2–5 ml was collected intraoperatively from all women for the study; on the eve of the operation, saliva was also collected from all women. In biological fluids, we assessed the level of interleukins (IL) and vascular endothelial growth factor. Results. A statistically significant correlation was found between BMI and the level of IL-1 in saliva (r = 0.391, p = 0.015), as well as the level of IL-8 in peritoneal fluid (r = 0.311, p = 0.044). At the same time, a direct relationship was revealed between the level of BMI and the severity of chronic pelvic pain (r = 0.297, p = 0.046). In addition, we determined that there was an inverse relationship between the level of IL-8 in the peritoneal fluid and anti-Mullerian hormone (AMH) (r = –0.342, p = 0.026). Higher BMI in women with endometriomas was also associated with lower AMH (r = –0.478, p < 0.001). Conclusion. In the presence of ovarian endometriosis, an increase in BMI is associated with a greater severity of chronic pelvic pain, which is associated with an increase in inflammatory mediators - a statistically significant direct relationship between BMI and the level of IL-1 in saliva and IL-8 in peritoneal fluid was revealed. In addition, a high BMI is associated with lower ovarian reserve rates. Further study of the cytokine profile in women with endometriosis depending on body weight may contribute to the development of new personalized therapy regimens. Key words: endometrioma, endometriosis, cytokines, chronic pelvic pain, infertility.