Biomarkers of systemic inflammatory response in patients with tuberculosis, combined with HIV infection

Abstract

Aim: to study the severity of the systemic inflammatory response (SIR) in patients with tuberculosis combined with HIV infection. Materials and methods: we studied 44 patients with tuberculosis (TB) combined with HIV infection. The age of patients ranged from 24-57 years (35 men and 9 women). Intensity of SIR assessed with using serum levels of acute phase proteins (AFP) - C-reactive protein (CRP), α1-antitrisin (α1-AT), haptoglobin (Hp) and fibrinogen (F). The AFP was measured in sera using immunoturbidimetric method. The sera were studied on the day of admission patients. Statistically analyze was made using Student9s t test. Results: It was found that among the studied AFP most sensitive was of α1-AT. The level of α1-AT increased in the majority of patients (90,9%). CRP, a recognized classic indicator of systemic inflammation was increased in 81.8% of patients. The level of Hp was increased half of the patients (50.0%). Increasing the concentration of F was observed only in 18.1% of patients. An analysis of the concentration AFP showed that the mean value of CRP ( 34,9 ± 6,2 at the norm ≤3 mg / L; p Conclusion: Increased level of AFP indicating the presence of SIR in patients with pulmonary tuberculosis, combined with HIV infection. The most informative markers of SIR in these patients proved to α1-AT and CRP. Increased level of F for this patient was not typical.