Интравитреальное введение моксифлоксацина в комбинации с ванкомицином при субтотальной витрэктомии при послеоперационном эндофтальмите

Abstract

Acute bacterial postoperative endophthalmitis is inflammation of the internal eye eyeball tunic with the formation of exudate in the vitreous chamber and / or anterior chamber which can quickly lead to an irreversible loss of visual functions, and sometimes loss of the eye as an organ developing most often after surgical treatment of cataracts. The generally accepted standard of the acute bacterial postoperative endophthalmitis treatment (the «gold standard») includes vitrectomy, sampling of contents of the vitreous chamber and anterior chamber for microbial analysis, and determination of its sensitivity to antibiotics. Intravitreal injection of Vancomycin at a dose of 1 mg/0.1 ml and Ceftazidim at a dose of 2.25 mg / 0.1 ml at the final stage of the intervention. To date, the choice of antibacterial substances for intravitreal injections remains open. One of the drugs that meet the requirements is Moxifloxacin; antibacterial drug of fluoroquinolone group with bactericidal effect. It is active against a wide range of Gram-positive bacteria and Gramnegative bacteria, anaerobic, acid-resistant and atypical bacteria. Keywords: acute bacterial postoperative endophthalmitis, intravitreal administration of antibacterial drugs, safety of moxifloxacin and vancomycin, endophthalmitis treatment standards