Abstract
To diagnose precancerous diseases of the oral mucosa in dentistry today, a large number of techniques are used. Despite the fact that the best method is still a morphological study, its use in a clinical setting is extremely difficult. Non-invasive examination methods, such as luminescent and autoluminescent methods, optical coherence tomography, simple and extended stomatoscopy, are being widely developed. All of them also have a number of disadvantages, including inaccessibility to primary care dentists, the complexity and duration of the study, and the inability to assess the dynamics of the therapy. One of the promising methods is the method for assessing the level of cytokines in the oral fluid. The purpose of this work is to study the possibility of assessing the dynamics of the ongoing treatment of precancerous diseases of the oral mucosa by analyzing the level of pro- and anti-inflammatory cytokines in the oral fluid. 50 patients with precancerous diseases of the oral cavity were examined. Of these, 2 cohorts of 25 people were formed. In the main group, the drug “Eplan” was used as a keratoplasty; in the comparison group, a traditional treatment regimen was used. A survey of 25 healthy people was also carried out. Analysis of the level of pro-inflammatory and anti-inflammatory cytokines showed a significant increase in the concentration of these molecules in patients with dyskeratosis. After the treatment, there was a normalization of indicators in both groups with better dynamics in the main group. Conclusions were drawn about the possibility of using the level of salivary cytokines to predict the occurrence and malignancy of precancerous diseases of the oral mucosa, as well as to monitor the effectiveness of treatment.
Published Version
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