Abstract
We have analysed the results of the study of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’lungs in experimental allergic alveolitis in the dynamics of EAA development under the conditions of immobilization stress. The study included 62 female guinea pigs weighing 180-220 g, divided into 4 groups: 1 – intact guinea pigs (n=20); 2 – guinea pigs (n=14) with EAA under conditions of IS (1st day); 3 – guinea pigs (n=14) with EAA under conditions of IS (2nd day); 4 – guinea pigs (n=14) with EAA under conditions of IS (34th day). The results of the experimental study showed that a signifi cant increase in conjugated diene level in animal lungs was observed at all stages of EAA development under conditions of immobilization stress as compared to a control group, indicating the activation of this marker. The same changes occurred with MDA content, indicating excessive accumulation of this lipid peroxidation product in lung tissue. Intensive synthesis of free radical compounds caused activation of some components of the enzymatic system of antioxidant defence. In particular, a moderate decrease in superoxide dismutase activity in lung tissue is observed in response to an increased level of LOPs at early stages of EAA and immobilization stress development as compared to these indices in intact animals. The same situation is observed with catalase and ceruloplasmin activity in the lungs of guinea pigs with modelled AA and IS.
Highlights
Among urgent problems of health care worldwide, a significant place is occupied by exogenous allergic alveolitis (EAA), which attracts attention of internists and allergists and is associated with a high incidence of this pathology in the structure of allergic diseases and an increase in severe complicated forms of this disease [1,2,3,4]
EAA is regarded as the pathology, associated with the risk of disability, manifested by chronic respiratory insufficiency, pulmonary heart or pneumosclerosis [5]
Experimental model of immobilization stress was induced by the following principle – the animals were immobilized on the back on an operation table, with atraumatic fixing of the extremities
Summary
Among urgent problems of health care worldwide, a significant place is occupied by exogenous allergic alveolitis (EAA), which attracts attention of internists and allergists and is associated with a high incidence of this pathology in the structure of allergic diseases and an increase in severe complicated forms of this disease [1,2,3,4]. Many investigations have shown association between the nervous system and the lungs [7] Functioning mechanisms of both systems are characterized by common pathogenic peculiarities acting in synergism, since the lungs play one of the leading roles in adaptation reactions of the body to stressful influences of various origins [5]. This is caused by the fact that the lungs are a target organ for «adaptation» hormones, because they are responsible for a large number of clearing (clearance) processes [9,10,11,12,13,14,15]. The aim of the research was to study lipid peroxidation processes and the condition of antioxidant protection in guinea pigs’ lungs in different periods of experimental allergic alveolitis (EAA) formation under the conditions of IS
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