Антибактериальная активность экспериментального коктейля бактериофагов против патогенной микробиоты наружных слуховых проходов собак и кошек

Abstract

Otitis externa is a common pathological condition of small pets requiring antimicrobial therapy. Widespread unjustified use of antibiotics exacerbates the existing problem of antibiotic resistance, and the number of isolates with multidrug resistance (MDR) is increasing. In this regard, an actual task is to search and evaluate alternative methods of antimicrobial therapy, for example, bacteriophages. In this study, the antibacterial activity of an experimental bacteriophage-based drug was evaluated against current participants in the etiopathogenesis of otitis externa in dogs and cats: Staphylococcus pseudintermedius, Staphylococcus aureus, Streptococcus pyogenes, Staphylococcus schleiferi subsp. Coagulans, Staphylococcus hyicus, Pseudomonas aeruginosa, Escherichia coli, Streptococcus canis, Enterococcus faecalis. The bacteriophage-based drug showed expressed antibacterial efficacy in vitro. When diluted 128 times, the cocktail of bacteriophages stably lysed test cultures of bacteria. There is a need for constant search and expansion of the number of virulent strains of bacteriophages to create an experimental means for the treatment of external otitis externa in dogs and cats, nevertheless, due to the positive results of the studies conducted, the actual potential of bacteriophages as an alternative to antibiotic therapy for pathologies of the external auditory canal in small pets is confirmed.