Исследования по изучению улучшения растворимости при разработке лекарственной формы с метионином и экстрактом куркумы длинной (Curcuma Longa)

Abstract

Introduction. Turmeric (Curcuma longa) is a medicinal plant and seasoning in Asia. Curcumin (diferuloylmethane) is the main active ingredient; a hydrophobic bioactive component contains in the rhizomes of turmeric (Curcuma longa). In recent years, curcumin has attracted tremendous attention not only for its use in cooking, but also for pleiotropic biological and pharmacological effects. However, its poor water solubility, low bioavailability and rapid metabolism are serious disadvantages for implementation in therapeutic practice. Therefore, researchers are attempting to increase the biological and pharmacological activity of curcumin using effective delivery systems and the addition of bioenhancers. Aim. Generalization and analysis of data presented in the databases PubMed, Web of science, Scopus, Google Scholar on methods of increasing the solubility and bioavailability of curcumin in the development of pharmaceutical compositions based on it. Materials and methods. Materials and methods. The object of research and search in the PubMed, Web of science, Scopus, Google Scholar databases was the substance curcumin, obtained from plant raw materials of long turmeric (Curcuma longa). We analyzed the data presented in the open press for the last 20 years (2000-2021), the request included indicators of the solubility and bioavailability of curcumin in vitro and in vivo. Conclusion. Various pharmaceutical studies of the use of oral combinations, including solid dispersions, nano/microparticles, polymer micelles, nanosuspensions, lipid-based nanocarriers, cyclodextrins, conjugates, have been developed to improve the oral bioavailability of curcumin. They have been shown to increase the solubility of curcumin, improve intestinal stability, and alter the absorption pathway.