In this paper, we establish a quantitative estimate for Durrmeyer-sampling type operators in the general framework of Orlicz spaces, using a suitable modulus of smoothness defined by the involved modular functional. As a consequence of the above result, we can deduce quantitative estimates in several instances of Orlicz spaces, such as L^p-spaces, Zygmund spaces and the exponential spaces. By using a direct approach, we also provide a further estimate in the particular case of L^p-spaces, with 1le p <+infty , that turns out to be sharper than the previous general one. Moreover, we deduce the qualitative order of convergence, when functions belonging to suitable Lipschitz classes are considered.