An experiment was conducted to study the effect of Panchagavya on Growth, Yield and Quality of Zucchini (Cucurbita pepo) in Protected Condition at Sam Higginbottom. University Of Agriculture Technology and Sciences, Prayagraj during summer 2023.The Treatment Performed best in terms of Plant Height (19.83 cm) and Number of node (12.00) after Foliar spray of Panchagavya (6%) at 30 DAS. Days to emergence of 1st male flower/ plant (28.87) after drenching of Panchagavya (9%) at 30 DAS. Days to emergence of 1st female flower/plant (34.03) after drenching of Panchagavya (9%) at 15 DAS. Days to 50% female flower/plant (34.67) Foliar spray of Panchagavya (6%) at 30 DAS.Days to 1st fruit setting/plant (43.00) after foliar spray of Panchagavya(9%)at 15 DAS. The Number of fruits/plant (4.67) after Foliar spray of Panchagavya (6%) at 15 DAS and the average weight of fruit (197.50g) after Foliar spray of Panchagavya (3%) at 15 DAS. Fruit length and Girth (25.00 Cm) and (16.00mm) after Drenching of Panchagavya (9%) at 30 DAS. Fruit Yield/plant (1.113 kg) after Foliar spray of Panchagavya (3%) at 15 DAS and Fruit yield per 250 m² was (3.71q). Fruit quality TSS°brix (3.22) after Foliar spray of Panchagavya (9%) at 30 DAS. The highest benefit cost ratio was found after Foliar spray of Panchagavya (3%) at 15 DAS (2.42). Result indicates that after Foliar spray of Panchagavya (3%) at 15 DAS were recommended for plant.