Arsenic (As) is the most important contaminant of the environment in northern Chile. The purpose of the present work is to study As-toxicity symptoms on Lupino microcarpus (lupine), an annual legume plant that constitutes part of the desert community of the pre-Andean area of the Antofagasta Region, Chile. This plant species is cultivated in As-agricultural soil collected from Chiu Chiu (northern Chile) which is classified as arid soils. Control soil (0 - 20 cm depth) is collected from an area located in the central zone of Chile, which is classified as molli soil. The main physic-chemical characteristics of As-soil and the control soil are determined. Eighteen plastic pots of 1.6 L (fifteen for experimental and three for control) are filled with As-soil and control soil treatments. Two plants are cultivated in each pot and then separated leaves and roots for As-analysis. Visual As-toxicity symptoms such as foliar chlorosis, necrosis of the leaf tips and margins, leaf wilting and stunted are determined. Total As concentrations in soils where lupine is cultivated, reach levels between 5.3 - 14.2 mg·kg-1 d.w. (control soil As-level: 3.1 mg·kg-1). Roots show higher As-concentration than leaves, both experimental plants as control plants (2.28 - 9.1 mg·kg-1 d.w., and 0.76 mg·kg-1 d.w., respectively) and low values of transport index (TI) (0.16 - 0.34). All of visual As-toxicity symptoms determined is showed by lupin cultivated in As-agricultural soils. Neither control lupin plant suffers any toxicity symptoms. The results indicate that lupine plants do not resist contamination and accumulated higher levels of As in roots. Lupine can be used in the phytostabilisation of As immobilizing it by microbial activity in agricultural soil.