Meeting Abstracts1 May 1970Hypertension and Hypogenitalism: Two New Varieties of This Clinical Association.Otto Kuchel, M.D., Pavel Hamet, M.D., Wojciech Nowaczynski, D.SC., Marcel Cadotte, M.D., Jacques Genest, M.D., F.A.C.P.Otto Kuchel, M.D.Search for more papers by this author, Pavel Hamet, M.D.Search for more papers by this author, Wojciech Nowaczynski, D.SC.Search for more papers by this author, Marcel Cadotte, M.D.Search for more papers by this author, Jacques Genest, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-72-5-788_4 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptFifteen to 25% of patients with gonadal dysgenesis have "essential" hypertension. The deficiency of 17-hydroxylation is another rare form of hypertension associated with hypergonadotropic hypogenitalism. Two new varieties of this association are described.1. A syndrome of severe hypertension affecting three siblings (two sisters, one brother) is associated with hypogenitalism (ovarian agenesis and cryptorchism, respectively), decreased hearing, renal insufficiency, and decreased platelets adhesiveness. At autopsy of one sister a marked thymic hyperplasia and hypoplasia of several organs were found. Adrenals presented hyperplasia of zona glomerulosa and produced excessive deoxycorticosterone and compound "S". Plasma aldosterone and compound "S" secretion rate are... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Montreal Canada PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1970Volume 72, Issue 5Page: 788-789KeywordsAldosteroneAutopsyBlood plasmaHearingHypertensionPlatelets Issue Published: 1 May 1970 PDF DownloadLoading ...