Purpose: This study evaluated the effects of surface treatment of zirconia with erbium-doped yttrium aluminum garnet (Er-YAG) laser on shear bond strength to resin cement. Materials and Methods: Thirty disc-shaped zirconia specimens (10 mm in diameter and 2 mm in thickness) were fabricated, randomly assigned to 3 groups (n = 10) and treated surface with: Gr. N) no treated surface, Gr. S) sandblasted with 50 micron alumina and Gr. L) treated with an Er-YAG laser. Zirconia surface was then applied with metal/zirconia primer prior to be cemented to composite cylinder (5 mm in diameter and 4 mm in thickness) with resin cement. Shear bond strength test was performed at a crosshead speed of 0.5 mm/min. Data were analyzed by ANOVA and Tukey HSD tests. Results: The means and standard deviations of shear bond strength (MPa) were: Gr. N) 10.79 ± 1.03, Gr. S) 14.15 ± 3.07, Gr. L) 14.11 ± 1.98. The treatment of zirconia surface were significantly affected to shear bond of resin adhesive to zirconia (p 0.05). Conclusion: Pretreatment of zirconia by Er-YAG laser improved bond strength to resin cement. The study suggested that Y-TZP ceramics should be treated surface with Er-YAG laser before cementation. Keywords: Zirconia; Resin Cement; Er-YAG Laser; Shear Bond Strength