Zingiber Officinale Roscoe Research Articles

Effect of Orijin Bitters, Aqueous Extracts of Hibiscus Sabdariffa Calyx and Zingiber Officinale Roscoe Rhizome on the Liver of adult wistar rats

BACKGROUND AND AIM: Orijin bitters, Hibiscus sabdariffa and Zingiber officinale roscoe are consumed for medicinal properties and their effects were evaluated in this study on adult wistar rats’ liver. METHODOLOGY: Thirty rats were divided into 6 groups, 5 in each. Group 1 received distilled water, group 2, 70cl/70kg/bw orijin bitters, group 3 orijin bitters and 200mg/kg/bw Hibiscus sabdariffa calyx aqueous extract, group 4 orijin bitters and 500mg/kg/bw Hibiscus sabdariffa calyx aqueous extract, group 5 orijin bitters and 200mg/kg/bw officinale rhizome aqueous extract, group 6 orijin bitters and 500mg/kg/bw Zingiber officinale rhizome aqueous extract. After administration, the rats were sacrificed and the liver harvested for biochemical and histological analysis. RESULTS: Aspartate aminotransferase and alkaline phosphate increased in group 2 while alanine transaminase decreased. Aspartate aminotransferase and alanine transaminase increased in most treatment groups while alkaline phosphate decreased. P < 0.05 was considered statistically significant. Orijin bitters distorted the liver tissue while Hibiscus sabdariffa and Zingiber officinale roscoe extracts resulted in restoration. CONCLUSION: Orijin bitters may possess toxicity to the liver. Hibiscus sabdariffa calyx and Zingiber officinale roscoe rhizome due to antioxidants present ameliorated the effect.

Effect of ginger (Zingiber officinale roscoe) inclusisve diet on testicular disorder in high cholesterol diet-induced obese rats: Involvement of cholesterol pathway.

BackgroundObesity, which is typically associated with hypercholesterolemia, has become a worldwide problem in recent times, raising alarming concerns on the testicular function in men in countries around the world. AimHence, this study focused at discovering the potency of ginger inclusive diet in correcting testicular disorder in a high cholesterol diet (HCD)-induced obese rat model focusing on cholesterol pathway. MethodsThe rodents were split up into seven separate groups (n = 10): healthy rats fed basal diet; obese untreated rats fed HCD; reference drug-treated obese rats, clomiphene citrate (CC, 2 mg/kg BW/day); obese rats fed high cholesterol diet with 2 % raw ginger (RG) inclusion; obese rats fed high cholesterol diet with 4 % RG inclusion; obese rats fed high cholesterol diet with 2 % boiled ginger (BG) inclusion; obese rats fed high cholesterol diet with 4 % BG inclusion for twenty-four weeks. Thereafter, the testosterone level, semen parameters, steroidogenic enzymes, lipid-metabolism related biomolecules, inflammation-related and apoptosis-related markers enzymes expression were assayed using testicular tissue. ResultResult showed that HCD disrupted the semen parameters, and affected testosterone level by causing a down-regulation in the gene expression of steroidogenic enzymes as well as up-regulation in the gene expression of inflammatory and apoptotic markers when compared with healthy control rats. Interestingly, treatment with ginger inclusive diet attenuated these effects with boiled ginger treatment having better results relative to the raw ginger treatment. ConclusionThis study confirms that a diet rich in ginger prevents testicular tissue by modulating the expression of key enzymes involved in inflammation, cholesterol metabolism, apoptosis, and steroidogenesis in HCD-induced obese rats, with boiled ginger possessing the greatest therapeutic benefit in the management of obesity-induced male fertility derangements, even beyond its impact on body weight regulation.

Evaluation of the sanitary and physiological quality of corn seeds (Zea mays) submitted to treatment with bioextracts and their binary combinations

The objective of the present study was to evaluate the effects of the application of bioextracts on seeds of creole corn, regarding their physiological and sanitary quality. The bioextracts of garlic (Allium sativum L), citronella (Cymbopogon nardus), cloves (Caryophilus aromaticus), ginger (Zingiber officinale roscoe), and their binary combinations were evaluated. Regarding the physiological quality of the seeds, the following parameters were evaluated: first germination (G1), germination (G), dry mass and seedling length (aerial and root). Regarding sanitary control, in vitro tests were carried out for the pathology of the seeds for Fusarium sp. and Aspergillus sp. The results of physiological quality showed a germination rate between 90.8-76.4% of the creole corn seeds treated with bioextracts and their combinations did not differ significantly from the control (84.9%), except when clove alone (3.0% of germination) was used. The results of dry mass, length of shoots and root plants followed a similar trend to that observed for germination analysis. Regarding sanity, the best result was obtained with clove bioextract, which completely inhibited the occurrence of Penicillium sp. Therefore, these studies allow to affirm that bioextracts can be efficient in controlling pathogens and maintaining the physiological quality of creole corn seeds.

Studies on photocatalytic mineralization of organic pesticides by bimetallic Cu-Zn nanoparticles derived from Zingiber officinaleRoscoe (ginger) using green chemistry approach.

Compared to monometallic nanoparticles, bimetallic nanoparticle synthesis and characterization have attracted more attention due to their superior environmental protection properties. In this study, we discuss the preparation and characterization of Cu-Zn bimetallic nanoparticles using Zinger extract, as well as their potential role in photocatalytic degradation of carbendazim, chlorpyrifos, monocrotophos, and cypermethrin. Surface properties were assessed with SEM and TEM, while UV-VIS, XRD, FTIR, and fluorescence spectroscopy were used to characterize the materials. It was observed that higher pH conditions were more conducive to the development of stable Cu-Zn BMNPs with diameters ranging from 60 to 100nm. UV-VIS spectroscopy showed that the Cu-Zn bimetallic nanoparticles photodegraded 53-95% of the pesticides, monocrotophos, chlorpyrifos, and carbendazim during the 24-72-h incubation period. A number of pesticides may be photocatalytically degraded by primary reactive radicals produced by nanoparticles. We propose that the use of bimetallic nanoparticles could be one alternative strategy for pesticide mineralization.

Proximate composition, levels of heavy metals and their associated risk assessment in ginger (Zingiber officinale roscoe)

Ginger is a medicinal plant widely used as a spice and botanically categorized in the Zingiberaceae family, Zingiber genus, and officinale species. Natural and anthropogenic sources can discharge heavy metals into the environment from which they enter the human body through food, water, air, and skin contact and cause detrimental health effects. In this study, ginger samples were randomly collected from five kebeles in Ilubabor and Bunno Bedelle zones, Southwest Ethiopia, from which a composite sample was made for analysis. Microwave-assisted digestion was carried out using concentrated nitric acid in the presence of hydrogen peroxide followed by atomic absorption spectrometer detection using different Association of Analytical Chemists, AOAC methods. Proximate analysis was performed with different standard operating procedures. The mean levels of heavy metals were 0.009 mg/kg for Arsenic, Chromium, and Lead and 0.01 mg/kg for cadmium while 578.2 mg/kg was obtained for iron. Proximate composition analysis shows 82.89%, 2.00%, 0.07%%, 1.63%, 3.42%, 9.99%, and 48.59 kcal for moisture, crude protein, crude fat, ash, crude fiber, carbohydrate, and energy, respectively. The validated method had acceptable linearity (R2 = 0.9978 - 0.9993), the limit of detection (8.18x10-5 - 0.0075), the limit of quantification (2.7x10-4 - 0.025), recovery (75 - 106.87%) and precision (4.77 - 13.97 %). The hazard index (HI) of the metals was less than one showing insignificant non-carcinogenic risk from exposure to a single or multiple possibly toxic elements from the studied ginger samples.

Induction of micro-rhizomes for in vitro ginger (Zingiber officinale Rosco) disease-free planting materials regeneration

Ginger has been a leading spice crop in Ethiopia until ginger bacterial wilt disease interrupted its production. The disease transmission is mainly through infected planting materials and products. Regeneration of healthy planting materials is among the best option to minimize the disease impact. This research aimed to induce and produce disease-free in vitro micro-rhizome in a combination of sucrose, BAP, ammonium nitrate, and silver nitrate. The results from observations indicated that sucrose and BAP were best combinations for induction of disease free micro-rhizomes. Ammonium nitrate and silver nitrate showed lower induction than sucrose and BAP combinations alone. The maximum viable number of micro-rhizome (5.67) and shoot number (10.33) were from 80.0 g/l sucrose and 6.0 mg/l BAP contained medium. Viability test indicated 80 % of the micro-rhizomes were sprouted after one month in soil. The micro-rhizome production potential observed in this experiment can enhance disease-free ginger production.

Promising roles of Zingiber officinale roscoe, Curcuma longa L., and Momordica charantia L. as immunity modulators against COVID-19: A bibliometric analysis

Zingiber officinale, Curcuma longa, and Momordica charantia are medicinal plants that are commonly used in the form of herbal tea, which is formulated to strengthen the immune system, especially against COVID-19 infection. Excellent antioxidant, anti-inflammatory, and immunostimulatory properties have been reported for their bioactive compounds, which have been shown to aid in stimulating immune systems as well as lowering the risk of severe COVID-19 such as lung injury. Yet, no bibliometric study on the subject is available. Hence, the purpose of this study is to quantitatively examine the existing articles related to the therapeutic potential of these three herbs, as well as their mechanisms of action in combating the SARS-CoV-2 virus. A total of 121 papers were retrieved from Scopus database up to 14th March 2023. The bibliometric analysis was conducted using VOSviewer software. Based on the literature search, Z. officinale was the most researched plant. India appeared as the most prolific country, with the highest number of articles contributed by two authors from India (Rathi, R. and Gayatri Devi, R.). In terms of keywords, the plants were associated with immune modulation, management of symptoms, antioxidant, anti-inflammatory and antiviral activities. Several important bioactive compounds were responsible for these effects such as gingerol, paradol, shogaol, curcumin, calebin A, momordicoside, karaviloside and cucurbitadienol. These compounds were hypothesized to prevent and cure COVID-19 by regulating inflammatory response, downregulating oxidative stress and modulating immunostimulatory activity. This review paper therefore supports the potential of Z. officinale, C. longa, and M. charantia to be formulated as a herbal blend for treating and preventing COVID-19 infection.

Reply to Letter to Editor by Elumalai et al. re : "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney".

Reply to Letter to Editor by Elumalai et al. re : "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney".

Letter to Editor on: "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney" by Akbari et al.

Letter to Editor on: "Ginger (Zingiber officinale roscoe) extract could upregulate the renal expression of NRF2 and TNFα and prevents ethanol-induced toxicity in rat kidney" by Akbari et al.

Nonlinear regression application in Aspergillus flavus radial mycelial growth inhibition by essential oils of Piper guineense Schum and Thonn., Zingiber officinale roscoe and Monodora myristica (Gaertn) Dunal

Nonlinear regression application in Aspergillus flavus radial mycelial growth inhibition by essential oils of Piper guineense Schum and Thonn., Zingiber officinale roscoe and Monodora myristica (Gaertn) Dunal

Studi Pengaruh Iradiasi Gamma Terhadap Kadar Senyawa Bioaktif dan Aktivitas Antiinflamasi Jahe Merah (Zingiber officinale roscoe)

Background: In Indonesia, the use of herbal plants in overcoming several health problems shows a fairly high rate. Red ginger is one of the herbs that is widely consumed and empirically has the property of relieving or reducing inflammation. However, as is well known, in general the microbiological contamination of herbs is quite high. To maintain the quality of herbal plants, special treatment is required, to ensure that microbial contamination is within safe limits. This study aims to determine the effect of gamma irradiation on the number of microbial contamination, and the bioactive content of 6,8,10-gingerol; 6-shogaol in 70% ethanol extract of red ginger, and its activity as an anti-inflammatory.
 Methodes: Samples of 70% ethanol extract of red ginger were irradiated with various doses of 0, 5, 7.5, 10 and 15 KGy. Microbiological contamination is determined in Total Plate Number and Yeast Mold Number. The content of compounds 6,8,10-gingerol and 6-shogaol was observed by high performance liquid method and their anti-inflammatory activity was observed by protein denaturation inhibition (BSA) method. Results: Gamma irradiation at doses of 0, 5, 7.5, 10 and 15 KGy reduced microbial contamination as the exposure dose increased, and did not affect the levels of bioactive 6,8,10-gingerol; 6-shogaol and its anti-inflammatory activity. The anti-inflammatory activity of 70% ethanol extract of red ginger is influenced by the content of bioactive compounds.
 Conclusion: Gamma irradiation is effective for decontaminating microbiological contaminants, and improving the quality of red ginger, and does not affect the bioactive levels contained and its anti-inflammatory activity (in vivo).
 
 Keywords: 6,8,10-gingerol, 6-shogaol; Anti-inflammatory ; Irradiation gamma rays; Zingiber officinale roscoe; Bovine serum albumin

Renoprotective effects of the ginger (Zingiber officinale) on Diabetic kidney disease, current knowledge and future direction: a systematic review of animal studies

ObjectiveDiabetic kidney disease affects approximately 40% of diabetic patients and is the leading cause of chronic kidney disease (CKD) worldwide. As a result, preventing renal complications in diabetic patients is critical. Ginger (Zingiber Officinale Rosco) is a popular spice and natral medicine. The present study was a systematic review focused on the existing evidence of the renoprotective effect of ginger extract on some features of diabetic kidney disease.MethodsThe literature was searched in online databases such as PubMed, Scopus, EMBASE, ProQuest databases, and Google Scholar from inception to July 2022.ResultsThis review included 41 articles that met the eligibility criteria. Ginger supplementation was found to be associated with a significant decrease in blood glucose in 28 studies. Nine studies showed a significant reduction in malondialdehyde (MDA) after supplementation. Also, seventeen studies showed decreased serum levels of creatinine. Fifteen studies reported a decrease in total cholesterol (TC) and fourteen studies showed a lowered triglycerides (TG) concentrations. In twenty-six studies, ginger reduced renal injuries due to diabetes.ConclusionGinger may improve blood sugar indices, lipid profile, some inflammatory markers, oxidative stress, and pathologic injuries in diabetic kidney disease. However, future well-designed clinical trials and meta-analyses are required for a solid consensus.

The Herbal Potential of Ginger (Zingiber officinale Roscoe) and Guava (Psidium guajava L.) as Supplements for the Management of Coronavirus Disease 2019 (COVID-19)

Increasing the body's immunity is one of the efforts to prevent infection with COVID-19. This literature review aims to describe the potential of ginger (Zingiber officinale roscoe) and guava (Psidium guajava L.) as supplements for the management of COVID-19. Grated ginger (Zingiber officinale roscoe) is used as a topical medication to treat swelling, rheumatism, and headaches. In vivo tests in rats that were immunosuppressed using cyclophosphamide showed that ginger essential oil given once a day orally for a week could increase the humoral immune response. Meanwhile, guava has high levels of polyphenols such as myricetin and apigenin compounds, ellagic acid, and anthocyanins. The high vitamin C content in guava contributes to immune defense by supporting various cellular functions of both the innate and adaptive immune systems.

6]-Shogaol Attenuates Oxaliplatin-Induced Allodynia through Serotonergic Receptors and GABA in the Spinal Cord in Mice.

Although oxaliplatin is a well-known anti-cancer agent used for the treatment of colorectal cancer, treated patients often experience acute cold and mechanical allodynia as side effects. Unfortunately, no optimal treatment has been developed yet. In this study, [6]-shogaol (10 mg/kg, i.p.), which is one of the major bioactive components of Zingiber officinale roscoe (Z. officinale), significantly alleviated allodynia induced by oxaliplatin (6 mg/kg, i.p.) injection. Cold and mechanical allodynia were assessed by acetone drop and von Frey filament tests, respectively. The analgesic effect of [6]-shogaol was blocked by the intrathecal injection of 5-HT1A, 5-HT3, and GABAB receptor antagonists, NAN-190 (1 μg), MDL-72222 (15 μg), and CGP 55845 (10 μg), respectively. Furthermore, oxaliplatin injection lowered the GABA concentration in the superficial laminae of the spinal dorsal horn, whereas [6]-shogaol injection significantly elevated it. The GAD (glutamic acid decarboxylase) 65 concentration also increased after [6]-shogaol administration. However, pre-treatment of NAN-190 completely inhibited the increased GABA induced by [6]-shogaol in the spinal dorsal horn, whereas MDL-72222 partially blocked the effect. Altogether, these results suggest that [6]-shogaol could attenuate oxaliplatin-induced cold and mechanical allodynia through 5-HT1A and 5-HT3 receptor antagonists located in the GABAergic neurons in the spinal dorsal horn in mice.

Effect of hibiscus sabdariffa l., zingiber officinale roscoe and piper nigrum l. On the hematological parameters of alloxan induced diabetic wistar rats.

Background: Diabetes is a disease condition of metabolism clinically expressed by chronic hyperglycemia and protein disorder; it has a link to several complications that cause morbidity and mortality and native plants with antidiabetic properties can be used to avoid further progression of the disease
 Objective: To investigate the antidiabetic properties of combined extract of hibiscus sabdariffa l., zingiber officinale roscoe and piper nigrum l. as well as its effect on selected hematological parameters in alloxan induced diabetic wistar rats
 Methods: Thirty (30) male wistar rats aged between 8-10 weeks, weighing 130g to 138g were divided into five groups of six rats each and acclimatized for a week prior to the commencement of the treatments. Of the 5 groups, 4 were induced with 170mg/kg body weight of alloxan. Diabetic rats were treated with 250mg/kg and 500mg/kg of the combined extract as well as 500mg/kg of metformin. The last diabetic group was left untreated and served as the negative control. All treatments were administered for 21 days with blood glucose level and body weight of the experimental animals regularly measured during the course of the treatment. At the end of the treatments, experimental rats were sacrificed and the blood collected was used to carry out hematological analysis including White Blood Cell count(WBC), Red Blood Cell count (RBC), Hemoglobin concentration (Hb), Hematocrit (Hct) or Packed Cell Volume (PCV) and Platelet (Plt). The results were subjected to analysis of variance (ANOVA) at P˂0.05.
 Results: The combined plant extract was observed to cause a decrease in the blood sugar level and also helped to maintain the body weight of animals. Similarly, the level of the PCV and the HB significantly increased (p<0.05) after administering the combined extract at the two selected doses. Also the WBC count was significantly (p<0.05) lowered following the administration of the combined extract.
 Conclusion: The combined extracts of Hibiscus Sabdariffa and Zingiber Officinale and Piper Nigrum have potential in the management of hyperglycemia as well as in the improvement of hematological parameters in alloxan induced diabetic rats.

Effect of hibiscus sabdariffa l. Piper nigrum l. And zingiber officinale r. Extract on serum electrolytes profile and changes in the pancreas of alloxan induced diabetic rat.

Diabetes Mellitus (DM) is the most common endocrine disease which is characterized by hyperglycaemia, altered metabolism of lipids, carbohydrates and protein with an increased risk of many complications such as liver and pancreas damage and altered serum electrolytes level. During the past few years many plants and spices have been used to manage DM. This work aimed to investigate the possible anti-diabetic effect of Hibiscus sabdariffa L., Zingiber officinale roscoe and Piper nigrum L. extract treatments in alloxan induced diabetic rats via studying pancreas, liver structure abnormalities and serum electrolytes level alteration. 30 male Wistar rats (130-180 g) were injected intraperitoneally and divided into five main groups each of 6 rats. The control group was injected with a single dose of saline solution (0.9% NaCl), diabetic group was injected with a dose of alloxan solution (170 mg/kg), high and low dose of 250 mg/kg and 500 mg/kg extract after induction of diabetes respectively and metformin treated group was injected at a daily dose 500 mg/kg metformin after induction of diabetes. Microscopic histopathology examination of pancreatic tissues showed decrease in islets of Langerhans size in the diabetic group, sinusoidal enlargement and increased fatty vacuoles in the liver tissues of the diabetic group. There were alterations in the serum electrolytes levels of the diabetic group. These abnormalities were healed after treatment of diabetic rats with extract which could have the ability to regenerate beta cells of islets of Langerhans. The present study could verify that the extract normalized the various serum electrolytes levels and histological abnormalities resulted due to diabetes metabolic disorders.

Characterization of 6-Gingerol for In Vivo and In Vitro Ginger (Zingiber officinale) Using High Performance Liquid Chromatography

Ginger (Zingiber officinale Rosco) belonging to the family Zingiberaceae is one of the world’s most important spices and produces a pungent, aromatic rhizome that is valuable all over the world. Qualitative and quantitative analysis of 6-gingerol in different parts (in vivo and in vitro) of Zingiber officinale using thin layer chromatography (TLC) and high performance liquid chromatography (HPLC) have been performed. Data of TLC showed spots having identical Rf value (0.15), according to the synthetic standards of 6-gingerol in all samples extract. 6-gingerol was detected in all extracts of different parts of ginger derived from in vivo and in vitro culture conditions. Quantitative determination of 6-gingerol using HPLC technique was carried out. Comparing with the peaks of 6-gingerol in synthetic standards, in vivo rhizomes and in vitro cultures of different ginger parts was showed similar UV spectra characteristics. The quantity of 6-gingerol in rhizomes (in vivo and in vitro) and in vitro microrhizomes (45.37; 42.64; 28.11 mg/g respectively), were showed a higher value than that of in vitro calli, shoots and roots (7.89; 7.46; 6.40 mg/g respectively).

To study the effect of foliar spray of urea and NAA on the recovery percentage and yield of dry zinger (Zingiber officinale roscoe)

Study was conducted department of Horticulture at Kulbhaskar Ashram P.G. College, Allahabad during 2016-17. To study the effect of foliar spray of Urea and NAA on the recovery percentage and yield of dry ginger recovery was calculated variety Baruwa Sagar (21.95, 21.73 and 21.87 per cent recovery of dry ginger) was superior to Rio-de-Janeiro (21.42, 20.78 and 21.17 %) in first year second year and in pooled analysis. in case of urea concentration, the U1 was superior to U0 in both the year and in pooled mean. In respect of NAA on the concentration was increased from lower to higher i.e., No, N1 and N2 the recovery of dry ginger per cent was also found to increase in ascending orders. The value were 21.15, 21.64 and 22.27, 20.78, 21.38 and 21.90 and 20.96, 21.47 and 22.09 per cent in the first second year and in pooled mean, respectively. The yield of dry ginger in the important character to Judge the effect of urea and NAA on the varieties under observation. Production of dry ginger was more in variety Baruwa Sagar to the extent of 62.92, 61.73 and 62.32 q/ha in comparison to variety Rio-de-Jeneiro which gave 61.08, 59.50 and 60.29 q/ha in first and second year and in pooled mean. It also found that the production of dry ginger was maximum when NAA 400 PPM was applied (64.27 and 26.81) was quality good to NAA 200 PPM (63.63 and 62.20) and minimum in No (58.09 and 56.81) in the first and second year. The interaction of urea with NAA showed that the production of dry ginger was maximum in U1 N2 followed by U1, N1 and minimum in Uo No showing values as 65.24 and 63.74, 64.34 and 62.54 and 54.39 and 53.28 q/ha, respectively in first and second year.

English

Cognitive decline induced by oxidative brain damage is the critical pathological hallmark of Alzheimer’s disease. Studies have shown that individual administration of Boswellia serrata Roxb (BS), Zingiber officinale Roscoe (ZO) and Ginkgo biloba L. (GB) extracts improved memory and learning through a different mechanism of actions. This study aims to compare the individual effects of each extract with their co-administration on memory impairment induced by scopolamine in mice. Memory dysfunction was induced by a single dose of scopolamine (1 mg/kg, i.p) and extracts were administered intraperitoneally in different doses for one week. Memory performance of the mice was evaluated using the object recognition task (ORT) and passive avoidance test (PAT). The outcomes from ORT demonstrated that, ZO and GB extracts at 200 mg/kg and BS extract just in combination group significantly enhanced (by 95%) the memory loss induced by scopolamine (P < 0.05). On the other hand, PAT results revealed that BS extract at 60 and 90 mg/kg, ZO and GB extracts at 200 mg/kg and their combinations noticeably improved the latency time (by 80%). Although in PAT, co-administration of extracts was more effective than either alone doses in augmenting of the memory function, ORT results showed no considerable differences. Key words: Boswellia serrata, Zingiber officinale, Ginkgo biloba, extracts, memory, scopolamine.

Phytochemical screening and evaluation of the antioxidant and antibacterial potential of Zingiber officinale extracts

Zingiber officinale roscoe rhizome has been very popular worldwide as a spice, but an auxiliary medicine in treatment of various disorders. In this study, we controlled the effect of the heating extraction in the case of ethyl acetate, ethanol and aqueous extracts on the antioxidant and antibacterial properties. Compounds of ethyl acetate extract were identified by gas chromatography-mass spectrometry (GC-MS). Results showed that zingiberene was present as the major compound (23.71%; 31.70%) followed by β-sesquiphellandrene (15.08%; 16.64%) and curcumene (16.47%; 14.42%) in the ethyl acetate extracts at 20°C and 40°C, respectively. The mineral composition of ginger rhizomes was carried out by the inductively coupled plasma–atomic emission spectroscopy (ICP–AES) analysis. Moreover, ethanol extracts presented the highest polyphenol content (297.63 and 322.11 µg EAG/mg Ex) at 20°C (EET1) and 40°C (EET2), respectively. The two ethanolic extracts were the most active against the DPPH free radicals with IC50 of 98.62 and 77.23 µg/mL, respectively. The two ethyl acetate extracts EAC1 and EAC2 revealed the best antibacterial efficiency compared to the other extracts against all bacterial strains with MIC values ranging from 0.03 to 0.12 mg/mL and MBC values ranging from 0.06 to 0.24 mg/mL. Results showed a good agreement between the antioxidant power of extracts and their content of phenolic compounds.