The rising prominence of renewable energy sources and the demand for efficient power distribution has led to the emergence of DC microgrids as a promising solution for localized energy generation and distribution. The effective operation of DC microgrids heavily relies on the performance of their DC-DC converters, which play a crucial role in regulating power flow and voltage. Selecting suitable DC-DC converters is thus essential to ensure optimal performance and stability of photovoltaic systems. This academic article presents a comprehensive comparative analysis of different non-isolated DC-DC converter topologies and their appropriateness for DC microgrid applications. The research delves into various converter types, including buck, boost, buck-boost, SEPIC, and Zeta converters, thoroughly examining their operating principles, control strategies, and advantages within the context of DC microgrids. The focus is on key performance metrics essential for a comprehensive evaluation, including efficiency, voltage regulation, transient response, power density, and cost-effectiveness. Through meticulous comparative analysis, it is established that the SEPIC and Zeta converters stand out as exceptional choices for DC microgrids. Their distinct advantages, such as reduced output ripple, improved efficiency, and wide input voltage range, position them as valuable contenders for modern power electronics applications, showcasing their excellence in addressing diverse voltage regulation needs. This academic article contributes valuable insights into the selection and application of DC-DC converters in DC microgrid systems, providing researchers, engineers, and industry stakeholders with a comprehensive understanding of the comparative advantages of these converters. The findings underscore the significance of choosing appropriate converters to achieve efficient energy conversion, optimal power distribution, and the advancement of renewable energy technologies in the context of DC microgrids. Keywords: DC-DC converters, SEPIC, ZETA, BUCK, BOOST.