Following the fashion of the conference Applied Linear Algebra—in honor of Richard Varga, which took place in Palić in October 2005, a celebration honoring another influential person in applied linear algebra community, the international conference Applied Linear Algebra—in honor of Ivo Marek was held in Novi Sad, Serbia, on 28–30 April 2008. The aim of ALA 2008 was to review numerous contributions of Ivo Marek and to report and discuss recent progress through the participation of international leaders in the field, who gathered in his honor. The conference was attended by 67 participants from 15 different countries around the world. The program included invited and contributed talks, as well as speeches and social activities. The talks presented at the conference covered a wide range of topics in numerical analysis and scientific computation, with an emphasis on matrix problems and their numerical solution. Eleven papers published in this special issue represent a selection of those presented at the conference. Four of them are dealing with eigenvalues: from a generalization of the Perron–Frobenius theory and an investigation of minimal eigenvalues of totally non-negative matrices, via generalized eigenvalues and matrix pencils, to the nonlinear eigenvalue problem and variational eigenproblem. Four papers deal with systems of equations: nonsymmetric linear systems connected with preconditioning, bilinear systems, and some properties of the Schur complement, as well. Iterative methods are the main subject of two papers related to matrix sector function, and simultaneous determination of complex polynomial zeros. Well-conditioned matrices are investigated in one paper, in which Fredholm integration equation is considered. The papers appear in the order described above, and they are all a fitting homage to Ivo Marek, a very distinguished person in mathematics in the Czech Republic and abroad. Ivo Marek was born in Prague in 1933. He received his BSc in mathematics in 1956, and his PhD in 1962, both from Charles University Prague. He became a Doctor of Sciences at Academy of Sciences, Prague in 1968, and Professor of Mathematics in 1977. According to his own words, his work in Nuclear Research Institute in Rez, a city not far from Prague, from 1956 to 1963, made a significant influence upon his further research and work. Since 1963 he is working as a Professor of Mathematics at Charles University of Prague, and later at Czech Technical University in Prague, where he is still an active developer of modern numerical analysis. He is an active member of New York Academy since 1995, and an active member of Academia Scientiarum et Artium Europaea, Salzburg. Besides his regular appointments, Ivo Marek has held visiting positions at several universities and research institutions in U.S.A., Russia, Spain, Germany, Sweden, and the Netherlands. His list of publications consists of more than 120 research papers. His research contributions span several areas of numerical analysis and operator theory: numerical solution of operator equations, numerical solution of partial differential equations, large-scale computations, multigrid and aggregation methods, K-positive operators with applications to problems of mathematical physics, homogenization, data processing. He has always been very active and encouraging his students and colleagues. He also served (and still serves) in several very important and highly rating journals (including this one). Among his honors, let us mention the Bolzano Silver Medal for Merits in Mathematics (1983), the Medal of Peace of the Charles University (1988), and especially the Gold Felber Medal of Czech Technical University for 2008. Ivo Marek, however, is not only a great scientist, but also a living proof that mathematics and music fit together, for he is a big connoisseur of music and of world composers. He used to play flute. He was also an excellent tennis player. He and his wife became champions of Czech republic in tennis—mixed pairs, some ‘few’ years ago. We dedicate this issue of Numerical Linear Algebra with Applications to our friend, Professor Ivo Marek, a creator, who has immensely contributed to the treasury of science as well as to opening the roads that lead to enrichment of knowledge and its application.