Zero TE Research Articles

Synthetic CT generation using Zero TE MR for head-and-neck radiotherapy.

MRI-based synthetic CTs (synCTs) show promise to replace planning CT scans in various anatomical regions. However, the head-and-neck region remains challenging because of patient-specific air, bone and soft tissues interfaces and oropharynx cavities. Zero-Echo-Time (ZTE) MRI can be fast and silent, accurately discriminate bone and air, and could potentially lead to high dose calculation accuracy, but is relatively unexplored for the head-and-neck region. Here, we prospectively evaluated the dosimetric accuracy of a novel, fast ZTE sequence for synCT generation. The method was developed based on 127 patients and validated in an independent test (n = 17). synCTs were generated using a multi-task 2D U-net from ZTE MRIs (scanning time: 2:33 min (normal scan) or 56 s (accelerated scan)). Clinical treatment plans were recalculated on the synCT. The Hounsfield Units (HU) and dose-volume-histogram parameters were compared between the synCT and CT. Subsequently, synthetic treatment plans were generated to systematically assess dosimetry accuracy in different anatomical regions using dose-volume-histogram parameters. The mean absolute error between the synCT and CT was 94 ± 11 HU inside the patient contour. For the clinical plans, 98.8 % of PTV metrics deviated less than 2 % between synCT and CT and all OAR metrics deviated less than 1 Gy. The synthetic plans showed larger dose differences depending on the location of the PTV. Excellent dose agreement was found based on clinical plans between the CT and a ZTE-MR-based synCT in the head-and-neck region. Synthetic plans are an important addition to clinical plans to evaluate the dosimetric accuracy of synCT scans.

Feasibility of Breath-Hold Zero TE Magnetic Resonance Imaging Sequence for Evaluation of Pulmonary Arteriovenous Malformations After Embolotherapy.

We obtained breath-hold zero TE (ZTE) magnetic resonance imaging for the evaluation of pulmonary arteriovenous malformations before and after embolotherapy. To the best of our knowledge, there have been no reports of ZTE for the entire lung imaging in single breath-hold scan time such as 20 seconds. Breath-hold ZTE magnetic resonance imaging can be a useful technique for magnetic resonance-based follow-up of vascular lung diseases without using contrast media, reducing the undesired artifacts from metallic devices.

Usefulness of novel fusion imaging with zero TE sequence and contrast-enhanced T1WI for cavernous sinus dural arteriovenous fistula

Evaluation of access routes and shunting points plays a crucial role in the treatment of cavernous sinus dural arteriovenous fistulas (CS-dAVF). Generally, these evaluations are performed using three-dimensional rotation angiography. However, assessing access routes becomes challenging in cases lacking anterior or posterior drainage routes. Zero TE magnetic resonance imaging (MRI) is an innovative technique enabling the visualization of cortical bone. By merging fusion images of zero TE and contrast-enhanced T1 weighted imaging (CE-T1WI), enhanced arteries can be visualized, resembling cranial bone-like three-dimensional rotation angiography. To determine the usefulness of fusion images in evaluating access routes and shunting points for dural arteriovenous fistulas, a comparison was made between these fusion images and three-dimensional rotation angiography in the same case. This report describes the application of fusion images in evaluating access routes and shunting points.

Development and Evaluation of Deep Learning-Based Automatic Segmentation Model for Skull Zero TE MRI in Children

Development and Evaluation of Deep Learning-Based Automatic Segmentation Model for Skull Zero TE MRI in Children

PHSPP05 Presentation Time: 3:10 PM: Optimization Strategies in MR-Only Workflow for Interstitial and Intracavitary Gynecological HDR Brachytherapy

<h3>Purpose</h3> Image-guided interstitial and intracavitary gynecological brachytherapy (IGBT) is advancing towards MR-only workflows because of MR's superior soft-tissue contrast for tumor delineation and tissue segmentation. However, current treatment planning still necessitates the use of CT/MR fusion to aid in needle reconstruction and quality assurance (QA). In this work, we present strategies to visualize needles on MR and provide QA procedures for MR-only IGBT with comparisons to the conventional CT/MR approach. <h3>Materials and Methods</h3> Three 6F interstitial plastic needles and one CT/MR-compatible intrauterine tandem and ring (T&R) applicator set were examined in this study with the Flexitron afterloading system (Elekta Brachytherapy, Netherlands). To visualize the needles, they were immersed in demineralized water and scanned without markers in a 3T MRI system (Signa Premier; GE Healthcare, Milwaukee, WI). MR images were acquired with three protocols: 3D T1W (TR\TE 552\10 ms, and 1 mm voxel), 3D T2W (TR\TE 3051\104 ms, and 1 mm voxel) and silent Zero TE sequence (TR\TE 1060\20 ms, and 0.58 mm voxel). For QA, a 2D MR protocol (T1W, 7-10 mm thick slice) was utilized that allowed a projection-like image of an EBT3-film-based setup which was also imaged (with CT/x-ray markers) in CT (Philips, Netherlands) and x-ray imager (Varian Medical Systems, Palo Alto, CA). This setup consists of attaching catheters and four vitamin-D pills to EBT3 film pieces. The four corners of each film piece (5" x 4") were marked with skin markers that are visible in CT and MR images. These skin markers served as surrogates for a 4-point registration system between all images, and the vitamin-D pills were used to assess registration quality. An efficient film handling/scanning protocol was designed for this work and the source first dwell position (FDP) on the film was determined using a commissioned source localization algorithm. The FDP was compared between film, x-ray/CT markers, and applicator library models. <h3>Results</h3> For needle visualization, ZTE images generated a positive contrast for the interstitial needles as compared to conventional T1 and T2 images (See Figure). For QA, the 2D MR slice and x-ray image clearly displayed applicators, needles, vitamin-D pills, and skin markers allowing accurate registration to film images, visualization, and localization of the catheters, source positions, and markers in one fused image (See Figure). The tandem tip from MR was 1.1 mm longer than that of the x-ray and model which was not evident in the vitamin-D matching, implying a potential MR artifact at the tip (Sub-Figure B) which should be taken into account while planning. FDP reconstruction errors from the needle tip in MR with respect to film and x-ray markers were less than 1 mm (Sub-Figure D). <h3>Conclusions</h3> While further investigation is required, ZTE imaging offers a promising alternative to CT imaging for needle reconstruction supporting MR-only gynecological brachytherapy treatment planning. However, MR-only workflow requires special considerations in QA to account for possible systematic shifts that could exceed the level of accuracy achieved in x-ray-based IGBT.

Application of Highly Flexible Adaptive Image Receive Coil for Lung MR Imaging Using Zero TE Sequence: Comparison with Conventional Anterior Array Coil.

(1) Background: Highly flexible adaptive image receive (AIR) coil has become available for clinical use. The present study aimed to evaluate the performance of AIR anterior array coil in lung MR imaging using a zero echo time (ZTE) sequence compared with conventional anterior array (CAA) coil. (2) Methods: Sixty-six patients who underwent lung MR imaging using both AIR coil (ZTE-AIR) and CAA coil (ZTE-CAA) were enrolled. Image quality of ZTE-AIR and ZTE-CAA was quantified by calculating blur metric value, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) of lung parenchyma. Image quality was qualitatively assessed by two independent radiologists. Lesion detection capabilities for lung nodules and emphysema and/or lung cysts were evaluated. Patients’ comfort levels during examinations were assessed. (3) Results: SNR and CNR of lung parenchyma were higher (both p < 0.001) in ZTE-AIR than in ZTE-CAA. Image sharpness was superior in ZTE-AIR (p < 0.001). Subjective image quality assessed by two independent readers was superior (all p < 0.05) in ZTE-AIR. AIR coil was preferred by 64 of 66 patients. ZTE-AIR showed higher (all p < 0.05) sensitivity for sub-centimeter nodules than ZTE-CAA by both readers. ZTE-AIR showed higher (all p < 0.05) sensitivity and accuracy for detecting emphysema and/or cysts than ZTE-CAA by both readers. (4) Conclusions: The use of highly flexible AIR coil in ZTE lung MR imaging can improve image quality and patient comfort. Application of AIR coil in parenchymal imaging has potential for improving delineation of low-density parenchymal lesions and tiny nodules.

Pulse encoding for ZTE imaging: RF excitation without dead-time penalty.

PurposeTo overcome limitations in the duration of RF excitation in zero‐TE (ZTE) MRI by exploiting intrinsic encoding properties of RF pulses to retrieve data missed during the dead time caused by the pulse.MethodsAn enhanced ZTE signal model was developed using multiple RF pulses, which enables accessing information hidden in the pulse‐induced dead time via encoding intrinsically applied by the RF pulses. Such ZTE with pulse encoding was implemented by acquisition of two ZTE data sets using excitation with similar frequency‐swept pulses differing only by a small off‐resonance in their center frequency. In this way, the minimum scan time is doubled but each acquisition contributes equally to the SNR, as with ordinary averaging. The method was demonstrated on long‐T2 and short‐T2 phantoms as well as in in vivo experiments.ResultsZTE with pulse encoding provided good image quality at unprecedented dead‐time gaps, demonstrated here up to 6 Nyquist dwells. In head imaging, the ability to use longer excitation pulses led to approximately 2‐fold improvements in SNR efficiency as compared with conventional ZTE and allowed the creation of T1 contrast.ConclusionExploiting intrinsic encoding properties of RF pulses in a new signal model enables algebraic reconstruction of ZTE data sets with large dead‐time gaps. This permits larger flip angles, which can be used to achieve enhanced T1 contrast and significant improvements in SNR efficiency in case the Ernst angle can be better approached, thus broadening the range of application of ZTE MRI.

Magnetic Resonance Imaging of Water Content and Flow Processes in Natural Soils by Pulse Sequences with Ultrashort Detection.

Magnetic resonance imaging is a valuable tool for three-dimensional mapping of soil water processes due to its sensitivity to the substance of interest: water. Since conventional gradient- or spin-echo based pulse sequences do not detect rapidly relaxing fractions of water in natural porous media with transverse relaxation times in the millisecond range, pulse sequences with ultrafast detection open a way out. In this work, we compare a spin-echo multislice pulse sequence with ultrashort (UTE) and zero-TE (ZTE) sequences for their suitability to map water content and its changes in 3D in natural soil materials. Longitudinal and transverse relaxation times were found in the ranges around 80 ms and 1 to 50 ms, respectively, so that the spin echo sequence misses larger fractions of water. In contrast, ZTE and UTE could detect all water, if the excitation and detection bandwidths were set sufficiently broad. More precisely, with ZTE we could map water contents down to 0.1 cm3/cm3. Finally, we employed ZTE to monitor the development of film flow in a natural soil core with high temporal resolution. This opens the route for further quantitative imaging of soil water processes.

State-of-the-art MR Imaging for Thoracic Diseases.

Since thoracic MR imaging was first used in a clinical setting, it has been suggested that MR imaging has limited clinical utility for thoracic diseases, especially lung diseases, in comparison with x-ray CT and positron emission tomography (PET)/CT. However, in many countries and states and for specific indications, MR imaging has recently become practicable. In addition, recently developed pulmonary MR imaging with ultra-short TE (UTE) and zero TE (ZTE) has enhanced the utility of MR imaging for thoracic diseases in routine clinical practice. Furthermore, MR imaging has been introduced as being capable of assessing pulmonary function. It should be borne in mind, however, that these applications have so far been academically and clinically used only for healthy volunteers, but not for patients with various pulmonary diseases in Japan or other countries. In 2020, the Fleischner Society published a new report, which provides consensus expert opinions regarding appropriate clinical indications of pulmonary MR imaging for not only oncologic but also pulmonary diseases. This review article presents a brief history of MR imaging for thoracic diseases regarding its technical aspects and major clinical indications in Japan 1) in terms of what is currently available, 2) promising but requiring further validation or evaluation, and 3) developments warranting research investigations in preclinical or patient studies. State-of-the-art MR imaging can non-invasively visualize lung structural and functional abnormalities without ionizing radiation and thus provide an alternative to CT. MR imaging is considered as a tool for providing unique information. Moreover, prospective, randomized, and multi-center trials should be conducted to directly compare MR imaging with conventional methods to determine whether the former has equal or superior clinical relevance. The results of these trials together with continued improvements are expected to update or modify recommendations for the use of MRI in near future.

AZTEK: Adaptive zero TE k-space trajectories.

Because of short signal lifetimes and respiratory motion, 3D lung MRI is still challenging today. Zero-TE (ZTE) pulse sequences offer promising solutions as they overcome the issue of short . Nevertheless, as they rely on continuous readout gradients, the trajectories they follow in k-space are not adapted to retrospective gating and inferred motion correction. We propose AZTEK (adaptive ZTE k-space trajectories), a set of 3D radial trajectories featuring three tuning parameters, to adapt the acquisition to any moving organ while keeping seamless transitions between consecutive spokes. Standard ZTE and AZTEK trajectories were compared for static and moving phantom acquisitions as well as for human thoracic imaging performed on 3 volunteers (1 healthy and 2 patients with lung cancer). For the static phantom, we observe comparable image qualities with standard and AZTEK trajectories. For the moving phantom, spatially coherent undersampling artifacts observed on gated images with the standard trajectory are alleviated with AZTEK. The same improvement in image quality is obtained in human, so details are more delineated in the lung with the use of the adaptive trajectory. The AZTEK technique opens the possibility for 3D dynamic ZTE lung imaging with retrospective gating. It enables us to uniformly sample the k-space for any arbitrary respiratory motion gate, while preserving static image quality, improving dynamic image quality and guaranteeing continuous readout gradient transitions between spokes, which makes it appropriate to ZTE.

Validation of Zero TE-MRA in the Characterization of Cerebrovascular Diseases: A Feasibility Study.

Zero TE-MRA is less sensitive to field heterogeneity, complex flow, and acquisition noise. This study aimed to prospectively validate the feasibility of zero TE-MRA for cerebrovascular diseases assessment, compared with TOF-MRA. Seventy patients suspected of having cerebrovascular disorders were recruited. Sound levels were estimated for each MRA subjectively and objectively in different modes. MRA image quality was estimated by 2 neuroradiologists. The degree of stenosis (grades 0-4) and the z-diameter of aneurysms (tiny group ≤3 mm and large group >3 mm) were measured for further quantitative analysis. CTA was used as the criterion standard. Zero TE-MRA achieved significantly lower subjective perception and objective noise reduction (37.53%). Zero TE-MRA images showed higher signal homogeneity (3.29 ± 0.59 versus 3.04 ± 0.43) and quality of venous signal suppression (3.67 ± 0.47 versus 2.75 ± 0.46). The intermodality agreement was higher for zero TE-MRA than for TOF-MRA (zero TE, 0.90; TOF, 0.81) in the grading of stenosis. Zero TE-MRA had a higher correlation than TOF-MRA (zero TE, 0.84; TOF, 0.74) in the tiny group and a higher consistency with CTA (intraclass correlation coefficient, 0.83; intercept, -0.5084-1.1794; slope -0.4952 to -0.2093) than TOF-MRA (intraclass correlation coefficient, 0.64; intercept, 0.7000-2.6133; slope -1.0344 to -0.1923). Zero TE-MRA and TOF-MRA were comparable in the large group. Zero TE-MRA had more accurate details than TOF-MRA of AVM and Moyamoya lesions. Compared with TOF-MRA, zero TE-MRA achieved more robust performance in depicting cerebrovascular diseases. Therefore, zero TE-MRA was shown to be a promising MRA technique for further routine application in the clinic in patients with cerebrovascular diseases.

Zero TE MRI for Craniofacial Bone Imaging

Zero TE MR imaging is a novel technique that achieves a near-zero time interval between radiofrequency excitation and data acquisition, enabling visualization of short-T2 materials such as cortical bone. Zero TE offers a promising radiation-free alternative to CT with rapid, high-resolution, silent, and artifact-resistant imaging, as well as the potential for "pseudoCT" reconstructions. In this report, we will discuss our preliminary experience with zero TE, including technical principles and a clinical case series demonstrating emerging applications in neuroradiology.

In-phase zero TE musculoskeletal imaging.

To introduce a new method for in-phase zero TE (ipZTE) musculoskeletal MR imaging. ZTE is a 3D radial imaging method, which is sensitive to chemical shift off-resonance signal interference, especially around fat-water tissue interfaces. The ipZTE method addresses this fat-water chemical shift artifact by acquiring each 3D radial spoke at least twice with varying readout gradient amplitude and hence varying effective sampling time. Using k-space-based chemical shift decomposition, the acquired data is then reconstructed into an in-phase ZTE image and an out-of-phase disturbance. The ipZTE method was tested for knee, pelvis, brain, and whole-body. The obtained images demonstrate exceptional soft-tissue uniformity free from out-of-phase disturbances apparent in the original ZTE images.The chemical shift decomposition was found to improve SNR at the cost of reduced image resolution. The ipZTE method can be used as an averaging mechanism to eliminate fat-water chemical shift artifacts and improve SNR. The method is expected to improve ZTE-based musculoskeletal imaging and pseudo CT conversion as required for PET/MR attenuation correction and MR-guided radiation therapy planning.

Zero TE MRI applications to transcranial MR-guided focused ultrasound: Patient screening and treatment efficiency estimation.

The high acoustic impedance of the skull limits the performance of transcranial magnetic resonance-guided focused ultrasound (tcMRgFUS) therapy. Subject suitability screening is based on skull parameters estimated from computed tomography (CT) scans. To assess the feasibility of screening for tcMRgFUS based on zero echo time (ZTE) MRI, and to explore the influence of measurable skull parameters in treatment performance. Retrospective. Sixteen patients treated with tcMRgFUS thalamotomy for tremor. ZTE on a 3.0T GE scanner. Baseline CT and ZTE images were processed to extract skull measures associated with treatment success: skull density ratio (SDR), skull thickness, and angle of incidence. Eight new metrics were proposed. CT and ZTE-based measures were compared. Each subject's energy-temperature curve was processed to extract a global estimate of efficiency and a measure of nonlinearity. These parameters were then correlated with the skull measures. Linear regression analysis to compare ZTE vs. CT-based measures, measures vs. efficiency, and measures vs. nonlinearity. Paired t-test to assess nonlinearity. CT and ZTE-based measures were significantly correlated (P < 0.01). In particular, classical metrics were robustly replicated (P < 0.001). The energy-temperature curves showed a nonlinear (logarithmic) relationship (P < 0.01). This nonlinearity was greater for thicker skulls (P < 0.01). Efficiency was correlated with skull thickness (P < 0.001) and SDR (P < 0.05). The feasibility of ZTE-based screening has been proven, potentially making it possible to avoid ionizing radiation and the extra imaging session required for CT. The characterization of the influence that skull properties have on tcMRgFUS may serve to develop patient-specific heating models, potentially improving control over the treatment outcome. The relationship of skull thickness with efficiency and nonlinearity empowers the role of this metric in the definition of such models. In addition, the lower association of SDR with the energy-temperature curves emphasizes the need of revisiting this metric. 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;50:1583-1592.

Investigation of zero TE MR in preoperative planning in dentistry

Preoperative planning in dentistry relies on imaging to assess the separation between the teeth and mandibular canal. Cone beam CT(CBCT) shows inferior contrast of the mandible canal and features radiation. In this work, the use of zero TE (zTE) imaging as an alternative to CBCT imaging for preoperative planning in dentistry is investigated. Twenty-two patients (11 males, 11 females, age 26–65) were enrolled in this prospective study. The performance of zTE imaging was assessed using CBCT as a gold standard in preoperative planning for tooth extraction (qualitative classification) and implanting (quantitative dimensional measurement). Zero TE imaging showed clear delineation of teeth and mandible, and showed better depiction of the mandible canal as compared to CBCT. In assessing the spatial relationship between the third molar and the mandibular canal, identical results were obtained from two readers based on zTE and CBCT images; in spatial measurements related to the second premolar, high intraclass coefficient was obtained in all the performed measurements between zTE and CBCT (0.782 to 0.921) and between reviewers (0.812 to 0.958). The results of Bland Altman analysis also indicated low level of bias (max −1.8%) and disagreements (max −15.1% to 11.3%) between the results of zTE and CBCT. Zero TE imaging may be a potential imaging tool in preoperative planning in dentistry when CBCT is undesirable.

Zero TE-based pseudo-CT image conversion in the head and its application in PET/MR attenuation correction and MR-guided radiation therapy planning.

To describe a method for converting Zero TE (ZTE) MR images into X-ray attenuation information in the form of pseudo-CT images and demonstrate its performance for (1) attenuation correction (AC) in PET/MR and (2) dose planning in MR-guided radiation therapy planning (RTP). Proton density-weighted ZTE images were acquired as input for MR-based pseudo-CT conversion, providing (1) efficient capture of short-lived bone signals, (2) flat soft-tissue contrast, and (3) fast and robust 3D MR imaging. After bias correction and normalization, the images were segmented into bone, soft-tissue, and air by means of thresholding and morphological refinements. Fixed Hounsfield replacement values were assigned for air (-1000 HU) and soft-tissue (+42 HU), whereas continuous linear mapping was used for bone. The obtained ZTE-derived pseudo-CT images accurately resembled the true CT images (i.e., Dice coefficient for bone overlap of 0.73 ± 0.08 and mean absolute error of 123 ± 25 HU evaluated over the whole head, including errors from residual registration mismatches in the neck and mouth regions). The linear bone mapping accounted for bone density variations. Averaged across five patients, ZTE-based AC demonstrated a PET error of -0.04 ± 1.68% relative to CT-based AC. Similarly, for RTP assessed in eight patients, the absolute dose difference over the target volume was found to be 0.23 ± 0.42%. The described method enables MR to pseudo-CT image conversion for the head in an accurate, robust, and fast manner without relying on anatomical prior knowledge. Potential applications include PET/MR-AC, and MR-guided RTP.

Commentary to Quantitative PET/MRI Evaluation and Application in Neurology

Introduction: With the high spatial resolution of magnetic resonance imaging (MRI) particularly for the soft tissue such as in brain and non-ion radiation involved, the integrative positron emission tomography (PET)/ MRI system is expected to provide almost equivalent image quality compared with PET alone or PET/CT system, and simultaneous MRI information that is not conventionally available [1]. PET-MRI opens new horizons in multi-parametric neuroimaging for clinical research that allows simultaneous imaging of multiple parametric changes such as blood flow and metabolism at the same time. While MRI could provide superior structural information, applying MRI anatomical priors to reduce the PET partial volume effect could be achieved to improve spatial resolution of PET images for clinical and research usages. Objectives: Further applications in brain tumors and cancer response monitoring have reported complementary and valid information that this relatively new modality could achieve based on newly developed techniques. Newer and better MRI-based attenuation correction (AC) such as zero TE (ZTE) for more bone-related tissue signal detection and faster reconstruction compared to UTE/Dixon has been reported [3-6]. Advanced MRI-based motion correction for PET image reconstruction, newer PET time of flight reconstruction and incorporation with compressed sensing techniques have offered attractive superior temporal and spatial resolutions for disease diagnosis and prevention [7-9]. We briefly review the applications of PET/MRI in neurology with two examples in Alzheimer’s disease and brain tumor cases in this commentary. Results: Numerous imaging studies in Alzheimer’s disease (AD) have been performed to study characteristic brain alterations including brain atrophy with earlier involvement of medial temporal lobe [10], brain hypo- perfusion in the posterior cingulate and parietal regions [11], reduced functional and structural connectivity in the default mode network (DMN) based on MRI findings [12] and hypo-metabolism based on PET imaging findings [13]. A regional coupling between metabolism of glucose (via PET kinetic analysis) and cerebral blood flow (CBF) had been reported with reductions post-caffeine compared to precaffeine conditions in controls [14], and in demented patients [15] based on separate scans. An evaluation of the real-time coupling of these two key imaging parameters with simultaneous acquisitions had not been performed before. For example, FDG metabolism had been found to increase twice as the energy brain activation needs (i.e., larger change in metabolism than change in CBF), and at a later time the unmetabolited fraction of the tracer was cleared off so that the tissue concentration of the tracer could reflect the metabolic rate [16,17]. Neurovascular coupling between neurochemistry (e.g., dopamine receptor occupancy) and hemodynamic change (e.g., cerebral blood volume) using simultaneous PET/fMRI acquisitions had been reported recently with similar temporal profile and dose response in non-human primates Conclusions: he article by Zhou [2] had evaluated the most up-to-date PET/MRI scanner performance with multiple functional and structural metrics together with application demonstrations. Voxel-wise analyses in the template space also showed the majority of brain voxels (>95%) with significant correlations (r>0.54, P<0.05) between PET/MRI with Dixon MR-based AC method and PET/CT based on SUVR (standard uptake value ratio, a quantitative metric of normalized PET tracer dosage uptake) choosing cerebellum as the reference region (Figure 1A). A tight coupling between PET/MRI PET image and PET/CT PET image with a slope of fitting close to 1 in the middle temporal gyrus (MTG) was demonstrated in (Figure 1B). Furthermore, the global mean difference based on SUVR between PET/MRI and PET/CT was small using Dixon MR-based AC and PET/CT (difference=4%), And our findings agree with currently accepted notion that the MRI-based AC could achieve comparable imaging quality to standard-CT AC, with ≤ 5% differences between the PET/MRI and PET/CT PET images. The integrated PET/ MRI images showed comparable image quality to stand-alone imaging modality (both MRI and PET) with the gains of simultaneous multiparametric acquisitions, reduced scan time and potential patient discomfort. Furthermore, tight correlation between blood flow and metabolism was found in several brain gray matter regions including the temporal lobe in patients.

Zero TEMR bone imaging in the head

PurposeTo investigate proton density (PD)‐weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures.MethodsA rotating ultra‐fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft‐tissues. An inverse logarithmic image scaling (i.e., −log(image)) was used to highlight bone and differentiate it from surrounding soft‐tissue and air. Furthermore, a histogram‐based bias‐correction method was developed for subsequent threshold‐based air, soft‐tissue, and bone segmentation.ResultsPD‐weighted ZT imaging in combination with an inverse logarithmic scaling was found to provide excellent depiction of cranial bone structures. In combination with bias correction, also excellent segmentation results were achieved. A two‐dimensional histogram analysis demonstrates a strong, approximately linear correlation between inverse log‐scaled ZT and low‐dose CT for Hounsfield units (HU) between −300 HU and 1,500 HU (corresponding to soft‐tissue and bone).ConclusionsPD‐weighted ZT imaging provides robust and efficient depiction of bone structures in the head, with an excellent contrast between air, soft‐tissue, and bone. Besides structural bone imaging, the presented method is expected to be of relevance for attenuation correction in positron emission tomography (PET)/MR and MR‐based radiation therapy planning. Magn Reson Med 75:107–114, 2016. © 2015 Wiley Periodicals, Inc.

Zero TE MR bone imaging in the head.

To investigate proton density (PD)-weighted zero TE (ZT) imaging for morphological depiction and segmentation of cranial bone structures. A rotating ultra-fast imaging sequence (RUFIS) type ZT pulse sequence was developed and optimized for 1) efficient capture of short T2 bone signals and 2) flat PD response for soft-tissues. An inverse logarithmic image scaling (i.e., -log(image)) was used to highlight bone and differentiate it from surrounding soft-tissue and air. Furthermore, a histogram-based bias-correction method was developed for subsequent threshold-based air, soft-tissue, and bone segmentation. PD-weighted ZT imaging in combination with an inverse logarithmic scaling was found to provide excellent depiction of cranial bone structures. In combination with bias correction, also excellent segmentation results were achieved. A two-dimensional histogram analysis demonstrates a strong, approximately linear correlation between inverse log-scaled ZT and low-dose CT for Hounsfield units (HU) between -300 HU and 1,500 HU (corresponding to soft-tissue and bone). PD-weighted ZT imaging provides robust and efficient depiction of bone structures in the head, with an excellent contrast between air, soft-tissue, and bone. Besides structural bone imaging, the presented method is expected to be of relevance for attenuation correction in positron emission tomography (PET)/MR and MR-based radiation therapy planning.

Multi-Band-SWIFT

A useful extension to SWIFT (SWeep Imaging with Fourier Transformation) utilizing sidebands of the excitation pulse is introduced. This MRI method, called Multi-Band-SWIFT, achieves much higher bandwidth than standard SWIFT by using multiple segmented excitations (bands) of the field of view. A description of the general idea and variants of the pulse sequence are presented. From simulations and semi-phenomenological theory, estimations of power deposition and signal-to-noise ratio are made. MB-SWIFT and ZTE (zero-TE) sequences are compared based on images of a phantom and human mandible. Multi-Band-SWIFT provides a bridge between SWIFT and ZTE sequences and allows greatly increased excitation and acquisition bandwidths relative to standard SWIFT for the same hardware switching parameters and requires less peak amplitude of the radiofrequency field (or greater flip angle at same peak amplitude) as compared to ZTE. Multi-Band-SWIFT appears to be an attractive extension of SWIFT for certain musculoskeletal and other medical imaging applications, as well as for imaging materials.