1. 1) The first recognized cases of T. rhodesiense sleeping sickness occurred in Northern Rhodesia, Nyasaland, and Southern Rhodesia between 1908 and 1912. At this time sporadic cases only occurred in the Rhodesias, but there was an epidemic in Nyasaland. 2. 2) The epidemic spread northwards reaching Central Tanganyika in the 1920's, and Uganda and Kenya in the 1940's. With each extension, the disease has become more acute and the strains more rapidly lethal to experimental animals. 3. 3) In Southern Rhodesia the disease remains sporadic and relatively chronic, with the occurrence of “healthy carriers.” 4. 4) In Northern Rhodesia epidemics have occurred, but the disease remains relatively chronic as compared with the epidemic areas of East Africa. 5. 5) In Ngamiland and the Chobe districts of Bechuanaland sporadic cases have occurred since 1934 (possibly since 1909), but since 1957 minor epidemic conditions have appeared. 6. 6) In areas which have been affected by epidemic Rhodesian sleeping sickness, after the disease has been controlled, sporadic cases continue to occur, and these cases in time gradually become less acute. 7. 7) T. brucei was present in Tanganyika before 1914. Epidemic T. rhodesiense was absent, but invaded the Territory during the first World War: it is not surprising, therefore, that there is a wide distinction between these two “species” in terms of infectivity to man. 8. 8) T. brucei in domestic stock and T. rhodesiense in man both occur sporadically in Southern Rhodesia. Since the time of European settlement there has been no recorded epidemic of sleeping sickness: it is unlikely, therefore, that such a marked distinction in human infectivity exists as in Tanganyika; i.e., the theories of Kinghorn and Yorke (1912a) and of Bruce (1915) on the identity of T. brucei and T. rhodesiense still await experimental proof. 9. 9) Several cases of sporadic trypanosomiasis caused by T. rhodesiense (as here defined) have occurred in man in areas outside the normal “rhodesiense area.” 10. 10) In the better authenticated instances the strains from these sporadic cases from outside the “rhodesiense area” might have been derived either from T. brucei or T. gambiense, since both exist in the areas concerned. The original strain, from which the epidemic form of T. rhodesiense has been derived, arose in the Zambezi basin, this is so far removed from any known focus of T. gambiense as to make it unlikely that the strain was derived from anything other than T. brucei.