In models with more than one Higgs doublet, the Yukawa couplings of the d-type (u-type) quarks are changed by a factor A/sub d/ (A/sub u/), which is often a ratio of vacuum expectation values. Abbott, Sikivie, and Wise showed that the K/sub L/-K/sub S/ mass difference places stringent constraints on A/sub u/ (A/sub u/< or approx. =10 for a charged-Higgs-boson mass of m/sub W/); however, this bound is very sensitive to the charged-Higgs-boson mass and to small Kobayashi-Maskawa mixing angles. We note that if the enhancement is greater than 4--5, then the top quark's Yukawa coupling will exceed its strong coupling, even if m/sub t/approx.35 GeV. The effects of this enhancement on the e/sup +/e/sup -/ cross section, on energy levels, leptonic widths, and decay rate of t-quarkonium, and on top-quark decays are discussed; the former two effects are sensitive to neutral-scalar masses only, the latter to the charged-Higgs-boson mass; all of the effects are insensitive to small mixing angles. We also note that the best limit on A/sub d/ comes from recent data on the semileptonic branching ratio of b quarks.