Taiwanese Aboriginal Research Articles

Red Quinoa Bran Extract Prevented Alcoholic Fatty Liver Disease via Increasing Antioxidative System and Repressing Fatty Acid Synthesis Factors in Mice Fed Alcohol Liquid Diet.

Alcohol is metabolized in liver. Chronic alcohol abuse results in alcohol-induced fatty liver and liver injury. Red quinoa (Chenopodium formosanum) was a traditional staple food for Taiwanese aborigines. Red quinoa bran (RQB) included strong anti-oxidative and anti-inflammatory polyphenolic compounds, but it was usually regarded as the agricultural waste. Therefore, this study is to investigate the effect of water and ethanol extraction products of RQB on the prevention of liquid alcoholic diet-induced acute liver injury in mice. The mice were given whole grain powder of red quinoa (RQ-P), RQB ethanol extract (RQB-E), RQB water extract (RQB-W), and rutin orally for 6 weeks, respectively. The results indicated that RQB-E, RQB-W, and rutin decreased alcoholic diet-induced activities of aspartate aminotransferase and alanine aminotransferase, and the levels of serum triglyceride, total cholesterol, and hepatic triglyceride. Hematoxylin and eosin staining of liver tissues showed that RQB-E and RQB-W reduced lipid droplet accumulation and liver injury. However, ethanol extraction process can gain high rutin and antioxidative agents contents from red quinoa, that showed strong effects in preventing alcoholic fatty liver disease and liver injury via increasing superoxide dismutase/catalase antioxidative system and repressing the expressions of fatty acid synthesis enzyme acetyl-CoA carboxylase.

The Color Expressions in the Traditional Costumes of Taiwanese Indigenous Peoples

With respect to both fiber and color the clothing material of Taiwan’s indigenous people came predominantly from nature. Atayal woven materials are a distinct example of how ethnic symbolism can be expressed through the combining of color and fabric patterns in weaving and dying. In order to understand Atayal fabric color use and distribution, this research first utilizes PANTONE FASHION + HOME cotton planner to contrast fabric color, and after comparison, color specimens are input one at a time into Color Schemer Studio’s color wheel statistics system. In order to analyze Atayal fabric colors, this study particularly performs color scope analysis on sub-groups for which research specimens are relatively abundant, such as the Tayal’s Beishi group and Nanao Group; and the Sediq’s Wushe Group, Wanda Group, and Taroko Group. Beishi group fabrics use a comparatively wide range of color and a more diverse number of combinations. The main colors they use include white, red, orange, yellow, green, blue, and other colors. The colors used by the Wushe Group and Wanda Group in their fabrics include white, red, blue and others. While the number of specimens collected for this study is limited, it is possible to understand, what the color preferences of sub-tribes are through their color schemes. The most predominant color schemes involve similar colors, contrasting colors, and complimentary colors.

“Utux Tmninun U, ini sruwa muway pusu dnui rudan sunan ka hiya”: Reading Naboth’s Refusal (1 Kings 21:3) from the Sediq Mother Tongue

Since the advent of the vernacular Bibles for the Taiwan Indigenous Peoples (TIP), the TIP Christians are privileged to read and hear the Word of God in their ‘ancestral tones’ with familiarity and attachment. Sediq people, the nation the author belongs to, have also been privileged from the publication of the vernacular Bible. Most Sediq people are welcoming this vernacular Bible and feel blessed to use their ancestor’s language to communicate with God. However, the scarcely discussed issues are that the biblical reading and interpretive approaches employed by the Sediq people are distinctive. Namely, Sediq people’s vernacular involves Sediq’s cultural resources-philology, traditional narratives, traditional stories, cultural meanings, traditional philosophies and worldviews-into the interaction with the contents and stories of the vernacular Bible. This paper argues the significance of embracing vernacular as a foundation for biblical reading, how this acceptance shifts the role of the vernacular Bible and how this approach contributes to the contextual, decolonial and postcolonial reflections on the TIP’s land issues by reading 1 Kings 21:3, one of the verses that resonating TIP’s ancestral and cultural wisdom. Keywords: Sediq People, Taiwan Indigenous Peoples, land issues, ancestral philosophies

ARTventures: Art and Life in the Contemporary Pacific

The unpublished work ARTventures: Art and Life in the Contemporary Pacific is a literary memoir recounting Susan Cochrane’s unorthodox life as a roaming curator of contemporary Pacific art. The narrative intertwines vignettes of the author’s personal life with her experiences as a “poken” (slang  for English-speaking foreigner) in New Caledonia; on fieldwork trips collecting art in remote areas of Papua New Guinea, the Solomon Islands, and Vanuatu; and encountering Māori and Pasifika artists in Aotearoa New Zealand, and Aboriginal Taiwanese in Taiwan. The text is subtly layered with insights into the attitudes and operations of the art world and strategies to establish Indigenous art in its own right.

Changes in the quick mild cognitive impairment test over time: A normative study in an adult sample in Taiwan

The Quick Mild Cognitive Impairment (Qmci) test has been suggested to be an easy-to-use and precise screening tool for detecting postoperative cognitive dysfunction (POCD). To provide essential information for future POCD studies in Taiwan, the present study provided data regarding the Taiwan version of the Qmci (Qmci-TW) test conducted in the normative Taiwanese population and changes in them over time. The present study recruited adult native Taiwanese volunteers without known neurologic or psychiatric diseases. All enrolled participants received protocolized serial Qmci-TW test at baseline, 2-day follow-up, and 6-month follow-up. In total, 30 participants, 15 men and 15 women, were enrolled in this study. The baseline Qmci-TW score ranged from 55 to 80, with a mean of 68.9 and a standard deviation (SD) of 7. At 2-day follow-up, the mean Qmci-TW test score was significantly higher (by 5.3; SD=7.3) than that at baseline (P=0.001). At 6-month follow-up, the mean Qmci-TW score was 71.3 (SD=6.1), with no significant difference compared with that at baseline. The decline in Qmci-TW scores by>9 points on postoperative day 1 and by>11 points at 6-month follow-up was the criterion for POCD. The present study provided data regarding the Qmci-TW test conducted in the normative Taiwanese population and its time trajectory during the 6-month follow-up.

Social Policies for Older Indigenous People in Taiwan

Social Policies for Older Indigenous People in Taiwan

Traditional Houses of the Paiwan in Taiwan

The Paiwan, an Austronesian-speaking ethnic group, are one of sixteen Aborigines of Taiwan. This is an essay about the ethnography of traditional houses of the Paiwan. This is an essay about the ethnography of traditional houses of the Paiwan. I will describe structures, functions and construction process of traditional houses, and discuss briefly the social process and cultural meanings of houses. I have argued in an earlier paper that the Paiwan is a ‘house-based society’, in which social and cultural reproduction are bound up with the reproduction of houses. The goal of marriage is the mission of reproduction, and the ideal conjugal relationship is the one in which the couple share a common devotion to the reproduction of the house they created. In this paper I reconsider this point of view, and I propose that the parent-child relationship and the siblingship in the family are equally important. Because the traditional houses of the Paiwan are made of stone slabs, the process of making houses is quite long. In contrast, marriage may be short-lived and fragile. Even when the marriage relationship is terminated due to divorce, the process of building and maintaining a house will not stop, and this motivation could be maintained by the parent-child relationship and the siblingship.

Stressful Experiences, Connection, and Depressive Symptoms Among Taiwanese Han and Indigenous Youth.

This study examined Taiwanese Han and indigenous (Tayal) youth’s experiences of stressful life events, the association between stressful experiences and depressive symptomology, and also the indirect and interactive effects of connection on the relationship between stressful experiences and depressive symptomology. Taiwanese Han (97%) is the majority group, whereas indigenous people make up 2.3% of Taiwan’s population. Taiwanese indigenous people have experienced disparities across socio-historical, educational, and economic aspects of their lives. This study included 291 eighth-grade participants (40% from the Tayal tribe, 48.8% female, and Mage = 13.44). The Han sample in this study all lived in cities, and the Tayal sample all lived in the tribal areas of the Northern Taiwan mountain regions. Person-centered (latent class analyses) and cumulative (sum of items) approaches were used to investigate family and school stressful events, respectively. Hierarchical regression analyses were conducted separately for the Han and Tayal participants to examine the role of family and school connection in relation to family and school stressors and depressive symptomology. Our results showed that stressful experiences are clearly linked to depressive symptomology and family connection was important to both Tayal and Han youth in supporting their coping with depressive symptoms. However, Tayal youth might be particularly vulnerable to family stressful events because family stressors disrupted their connection with their parents and thereby minimized the protective function of family relationships. To decrease the likely onset of depression during early adolescence, our results suggest that it is important for parents and other family members to monitor adolescents’ daily experiences of stress and provide support when needed. Furthermore, mental health interventions need to be tailored specifically for youth in specific racial, social, and economic contexts. Tayal youth mental health might benefit particularly from increasing school connection and decreasing stresses experienced in family contexts. Implications, limitations, and recommendations for future research are discussed.

SOUNDS ELISION BY TAIWANESE UNIVERSITY STUDENTS IN PRONOUNCING ENGLISH PHRASES

The study aims to figure out the phonological variations of sounds elision realized by Taiwanese university students in pronouncing several English phrases. Eight native Taiwanese students were chosen to support the analysis of the study. They consisted of 8 males and 8 females from the college of humanities and literature of Chung Chen University and from the faculty of foreign languages of Asia University, Taiwan. The study used a descriptive qualitative design. According to Ary, Jacob and Sorensen (2010), qualitative researchers seek to understand a phenomenon by focusing on the total picture rather than breaking it down into variables. The goal is a holistic picture and depth of understanding rather than a numeric analysis of data. After analyzing the data, it was found that the pronunciation of the elision of initial /h/, final /t/ and final /d/ sound realized by the Taiwanese university students were varied. Some still pronounced them and some elided them.

Reported sources of health inequities in Indigenous Peoples with chronic kidney disease: a systematic review of quantitative studies

BackgroundTo summarise the evidentiary basis related to causes of inequities in chronic kidney disease among Indigenous Peoples.MethodsWe conducted a Kaupapa Māori meta-synthesis evaluating the epidemiology of chronic kidney diseases in Indigenous Peoples. Systematic searching of MEDLINE, Google Scholar, OVID Nursing, CENTRAL and Embase was conducted to 31 December 2019. Eligible studies were quantitative analyses (case series, case-control, cross-sectional or cohort study) including the following Indigenous Peoples: Māori, Aboriginal and Torres Strait Islander, Métis, First Nations Peoples of Canada, First Nations Peoples of the United States of America, Native Hawaiian and Indigenous Peoples of Taiwan. In the first cycle of coding, a descriptive synthesis of the study research aims, methods and outcomes was used to categorise findings inductively based on similarity in meaning using the David R Williams framework headings and subheadings. In the second cycle of analysis, the numbers of studies contributing to each category were summarised by frequency analysis.Completeness of reporting related to health research involving Indigenous Peoples was evaluated using the CONSIDER checklist.ResultsFour thousand three hundred seventy-two unique study reports were screened and 180 studies proved eligible. The key finding was that epidemiological investigators most frequently reported biological processes of chronic kidney disease, particularly type 2 diabetes and cardiovascular disease as the principal causes of inequities in the burden of chronic kidney disease for colonised Indigenous Peoples. Social and basic causes of unequal health including the influences of economic, political and legal structures on chronic kidney disease burden were infrequently reported or absent in existing literature.ConclusionsIn this systematic review with meta-synthesis, a Kaupapa Māori methodology and the David R Williams framework was used to evaluate reported causes of health differences in chronic kidney disease in Indigenous Peoples. Current epidemiological practice is focussed on biological processes and surface causes of inequity, with limited reporting of the basic and social causes of disparities such as racism, economic and political/legal structures and socioeconomic status as sources of inequities.

Life cycle assessment of heavy metal contaminated sites: phytoremediation and soil excavation

Phytoextraction by native Taiwanese chenopod (Chenopodium formosanum Koidz.) and Napier grass (Pennisetum purpureum) for heavy metals such as chromium (Cr), nickel (Ni), and copper (Cu) was reported first. Maximum bioconcentration factors of Cu and Cr were 8.8 and 12.5 by Taiwanese chenopod. Napier grass cultivar Taishi No.4 plants demonstrated higher survivals than that of Taiwanese chenopod, under heavy metal stress in soils. All heavy metal accumulation and biomass data were employed, as well as historical engineering data were collected for conventional excavation-and-refill remediation of two sites. Life cycle assessment (LCA) was conducted for comparing environmental performances of phytoextraction and conventional remediation for two contaminated sites. Assuming one-year growth, three harvests were done and biomass was collected and sent to the nearest municipal incinerators, phytoextraction by both plants demonstrated superior environmental performances than conventional methods for contaminated site remediation. High quantities of fuels to haul the soils of conventional methods mainly contributed to the greenhouse gas emission. Phytoextraction has the most advantages for sites with lesser extents of pollution and time restraints. Environmental performances of phytoremediation were even better if energy recovered from biomass incineration is counted. Novelty statement Phytoextraction by native Taiwanese chenopod and Napier grass was firstly reported. Life cycle assessment was conducted for comparing the phytoextraction and conventional remediation. Phytoextraction demonstrated superior environmental performances. Energy reutilization of biomass recovered made phytoremediation more sustainable.

Clinical and epidemiological features in hospitalized young children with acute gastroenteritis in Taiwan: A multicentered surveillance through 2014–2017

Acute gastroenteritis (AGE) remains a significant health issue in children. The worldwide evolution of pediatric AGE pathogens had been recorded since the introduction of rotavirus vaccine. Ten years after the rotavirus vaccine was introduced to the private sectors in Taiwan, a nationwide study was conducted to elucidate the epidemiological changes among major AGE pathogens. From January 2014 to December 2017, children younger than 5 years old, hospitalized with AGE at 10 hospitals across Taiwan were enrolled. Stool specimens were tested for Salmonella spp., Campylobacter spp., Clostridiodes difficile, norovirus, and rotavirus by polymerase chain reaction (PCR). The epidemiological and clinical information was collected. Enteric pathogen were detected in 1983 (42.2%) of 4700 subjects, with Salmonella spp. (12.5%) being the leading cause of AGE, followed by norovirus (11.2%), rotavirus (8.7%), C. difficile (4.2%), Campylobacter spp. (1.0%), and a mixture of at least 2 of 5 above-mentioned pathogens (4.6%). The case distributions varied across different regions. In eastern Taiwan, rotavirus (21/131, 16.0%) remained the most common pathogen detected. The rotavirus vaccine uptake rate is significantly lower in patients with rotavirus AGE. Besides, rotavirus AGE frequently occurred in children with foreign parent(s), Taiwanese indigenous people, and those with the household monthly income<NT$ 60,000. Salmonella spp. and norovirus were two major pathogens of pediatric AGE in Taiwan during 2014-17. Providing low-to middle-income households with free rotavirus vaccine nationwide and an industry-led act to reduce salmonellosis should be considered by the authorities.

Applications of Semantic Web in integrating open data and bibliographic records: a development example of an infomediary of Taiwanese indigenous people

Purpose This study aims to develop a Web-based application system called Infomediary of Taiwanese Indigenous Peoples (ITIP) that can help individuals comprehend the society and culture of indigenous people. The ITIP is based on the use of Semantic Web technologies to integrate a number of data sources, particularly including the bibliographic records of a museum. Moreover, an ontology model was developed to help users search cultural collections by topic concepts. Design/methodology/approach Two issues were identified that needed to be addressed: the integration of heterogeneous data sources and semantic-based information retrieval. Two corresponding methods were proposed: SPARQL federated queries were designed for data integration across the Web and ontology-driven queries were designed to semantically search by knowledge inference. Furthermore, to help users perform searches easily, three searching interfaces, namely, ethnicity, region and topic, were developed to take full advantage of the content available on the Web. Findings Most open government data provides structured but non-resource description framework data, Semantic Web consumers, therefore, require additional data conversion before the data can be used. On the other hand, although the library, archive and museum (LAM) community has produced some emerging linked data, very few data sets are released to the general public as open data. The Semantic Web’s vision of “web of data” remains challenging. Originality/value This study developed data integration from various institutions, including those of the LAM community. The development was conducted based on the mode of non-institution members (i.e. institutional outsiders). The challenges encountered included uncertain data quality and the absence of institutional participation.

"The Book "" The History and Custom of Taiwan Indigenous Peoples "" and the Formation of the Indigenous Educational Policy in the Early Days of the Japanese Colonial Period "

&lt;p&gt;本文主要目的在於從《臺灣蕃人事情》報告，來看日治初期官方原住民教育政策之形成。《臺灣蕃人事情》是民政部事務囑託伊能嘉矩和粟野傳之丞呈給民政長官後藤新平的覆命書，此覆命書係為實施蕃人教育預作準備。本書大部分內容由人類學調查所組成，可作為從人類學的角度看待教育的特殊視角。在蕃人教育措施準備上，覆命書中提及針對各族原住民「開化發達」的程度不同，給予適當之教育措施。對照日本總督府隨後原住民教育政策之發展，覆命書確實有其若合符節之處，也有差異之處。會有差異之處的原因，在於殖產部門所管轄的原住民區域，發展出與文教部門不同的原住民教育措施。&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;&lt;p&gt;The main purpose of this article is to analyze the relation between the formation of the official indigenous education policy in the early period of Japanese colony and the report &amp;ldquo;The History and Custom of Taiwan Indigenous Peoples &amp;quot;. &amp;ldquo;The History and Custom of Taiwan Indigenous Peoples &amp;ldquo;was the official report for the Chief of the Civil Affairs, Goto Shinpei, by two officials of Department of Civil Affairs, Ino Kanori and Suo Chuanji. The purpose of survey was the preparations for educating indigenous peoples. Most part of this report was based on field study, which could help to see education from an anthropological perspective. For establishing an education system for indigenous peoples, it divided to the different levels of civilization of each different ethnic group of indigenous peoples, and then gave each an appropriate education. Comparing the subsequent development of the indigenous education system that Taiwan Governor’s Office of Japanese initiated, it found there were some similarity and difference between the official report and the practical policy. The reason for the difference based on the development of indigenous educational policy that was different from the educational unit in the indigenous areas under the jurisdiction of the developmental department.&lt;/p&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;

Genomic insights into population history and biological adaptation in Oceania.

The Pacific region is of major importance for addressing questions regarding human dispersals, interactions with archaic hominins and natural selection processes1. However, the demographic and adaptive history of Oceanian populations remains largely uncharacterized. Here we report high-coverage genomes of 317 individuals from 20 populations from the Pacific region. We find that the ancestors ofPapuan-related ('Near Oceanian') groups underwent a strong bottleneck before the settlement of the region, and separated around 20,000-40,000years ago. We infer that the East Asian ancestors of Pacific populations may have diverged from Taiwanese Indigenous peoples before the Neolithic expansion, which is thought to have started from Taiwan around 5,000years ago2-4. Additionally, this dispersal was not followed by an immediate, single admixture event with Near Oceanian populations, but involved recurrent episodes of genetic interactions. Our analyses reveal marked differences in the proportion and nature of Denisovan heritage among Pacific groups, suggesting that independent interbreeding with highly structured archaic populations occurred. Furthermore, whereas introgression of Neanderthal genetic information facilitated the adaptation of modern humans related to multiple phenotypes(for example, metabolism, pigmentation andneuronal development), Denisovan introgression was primarily beneficial for immune-related functions. Finally, we report evidence of selective sweeps and polygenic adaptation associated with pathogen exposure and lipid metabolism in the Pacific region, increasing our understanding of the mechanisms of biological adaptation to island environments.

Do We Need More Indigenous Nurses?

Data collected over the past four decades show the life expectancy of indigenous Taiwanese to be 8 to 10 years lower than the general, predominantly Han Chinese, population. This suggests the persistence of inequities in the public health system in Taiwan. Several facets of this issue, including lack of consideration of the characteristics and lifestyle of ethnic populations in health policy planning and implementation work and the continued location-based focus of medical care resource distribution policies, are being actively discussed. However, investigations of factors related to the relatively poor health status of indigenous Taiwanese have not considered the traumatic and lingering effects of colonisation. This article briefly introduces the health status of indigenous Taiwanese and the indigenous nursing workforce and then presents a review of the literature on factors related to the under-representation of indigenous Taiwanese in nursing programs and the nursing workforce. Indigenous Taiwanese were found to be absent from public-health policymaking. Moreover, indigenous-related traditional knowledge and values are not being effectively transmitted to younger generations. A diverse nursing workforce should reflect and respond to not only indigenous peoples but also the general population in Taiwan.

Identification of Beilschmiedia tsangii Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator.

Transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) plays a crucial role in regulating the expression of genes participating in cellular defense mechanisms against oxidative or xenobiotic insults. However, there is increasing evidence showing that hyperactivation of NRF2 is associated with chemoresistance in several cancers, including hepatocellular carcinoma (HCC), thus making NRF2 an attractive target for cancer therapy. Another important issue in cancer medication is the adverse effects of these substances on normal cells. Here, we attempted to identify a dual-selective NRF2 regulator that exerts opposite effects on NRF2-hyperactivated HCC cells and normal keratinocytes. An antioxidant response element driven luciferase reporter assay was established in Huh7 and HaCaT cells as high-throughput screening platforms. Screening of 3,000 crude extracts from the Taiwanese Indigenous Plant Extract Library resulted in the identification of Beilschmiedia tsangii (BT) root extract as a dual-selective NRF2 regulator. Multiple compounds were found to contribute to the dual-selective effects of BT extract on NRF2 signaling in two cell lines. BT extract reduced NRF2 protein level and target gene expression levels in Huh7 cells but increased them in HaCaT cells. Furthermore, notable combinatory cytotoxic effects of BT extract and sorafenib on Huh7 cells were observed. On the contrary, sorafenib-induced inflammatory reactions in HaCaT cells were reduced by BT extract. In conclusion, our results suggest that the combination of a selective NRF2 activator and inhibitor could be a practical strategy for fine-tuning NRF2 activity for better cancer treatment and that plant extracts or partially purified fractions could be a promising source for the discovery of dual-selective NRF2 regulators.

Ethnic Identification and Social Changes of the Rukai People, the Aborigines in Taiwan

Ethnic Identification and Social Changes of the Rukai People, the Aborigines in Taiwan

The Ami and Yami aborigines of Taiwan and their genetic relationship to East Asian and Pacific populations.

This article reports on the genetic characteristics of the Ami and Yami, two aboriginal populations of Taiwan. Y-SNP and mtDNA markers as well as autosomal SNPs were utilized to investigate the phylogenetic relationships to groups from MSEA (mainland Southeast Asia), ISEA (island Southeast Asia), and Oceania. Both the Ami and Yami have limited genetic diversity, with the Yami having even less diversity than the Ami. The partitioning of populations within the PCA plots based on autosomal SNPs, the profile constitution observed in the structure analyses demonstrating similar composition among specific populations, the average IBD (identical by descent) tract length gradients, the average total length of genome share among the populations, and the outgroup f3 results all indicate genetic affinities among populations that trace a geographical arc from Taiwan south into the Philippine Archipelago, Borneo, Indonesia, and Melanesia. Conversely, a more distant kinship between the Ami/Yami and MSEA based on all the markers examined, the total mtDNA sequences as well as the admixture f3 and f4 analyses argue against strong genetic contribution from MSEA to the Austronesian dispersal. The sharing of long IBD tracts, total genome length, and the large number of segments in common between the Ami/Yami and the Society Archipelago populations East Polynesia standout considering they are located about 10,700 km apart.

Multiple migrations to the Philippines during the last 50,000 years

Island Southeast Asia has recently produced several surprises regarding human history, but the region's complex demography remains poorly understood. Here, we report ∼2.3 million genotypes from 1,028 individuals representing 115 indigenous Philippine populations and genome-sequence data from two ∼8,000-y-old individuals from Liangdao in the Taiwan Strait. We show that the Philippine islands were populated by at least five waves of human migration: initially by Northern and Southern Negritos (distantly related to Australian and Papuan groups), followed by Manobo, Sama, Papuan, and Cordilleran-related populations. The ancestors of Cordillerans diverged from indigenous peoples of Taiwan at least ∼8,000 y ago, prior to the arrival of paddy field rice agriculture in the Philippines ∼2,500 y ago, where some of their descendants remain to be the least admixed East Asian groups carrying an ancestry shared by all Austronesian-speaking populations. These observations contradict an exclusive "out-of-Taiwan" model of farming-language-people dispersal within the last four millennia for the Philippines and Island Southeast Asia. Sama-related ethnic groups of southwestern Philippines additionally experienced some minimal South Asian gene flow starting ∼1,000 y ago. Lastly, only a few lowlanders, accounting for <1% of all individuals, presented a low level of West Eurasian admixture, indicating a limited genetic legacy of Spanish colonization in the Philippines. Altogether, our findings reveal a multilayered history of the Philippines, which served as a crucial gateway for the movement of people that ultimately changed the genetic landscape of the Asia-Pacific region.