This article explores the differences in the relationships among cultural values, personality, travel motivation, vacation activities, and lifestyle in the female and male youth travel markets. A path model is developed separately for the US female and male market. The equivalence of the model across the two markets is determined. The significant differences in the relationships between factors across the two groups are explored. The results suggest the same model holds in the two samples and both models had acceptable fit measures. However, there are significant differences in the strengths of the relationships between the factors. These findings suggest that gender-specific issues cannot be ignored in developing and planning tourism and marketing programs. The implications of the study for academics and practitioners are discussed.