In this volume of The Journal, Gidding et al, representing the TODAY study, report longitudinal data on cardiac biomarkers and their relationship to cardiovascular disease (CVD) risk factors and left ventricular structure and function in youth with type 2 diabetes (T2D). BNP, TNF-α, and troponin were elevated and increased over the 5-year study. However, these markers did not necessarily persist in individuals or in relationship to glycemia or CVD structure or function. The authors conclude that elevated serum concentrations of cardiac biomarkers were common in youth with T2D, but their clinical significance is unclear and will require further long-term study. The authors also emphasize that these biomarkers should be interpreted with caution—an important message if a youth with T2D has these labs drawn in an emergency department or otherwise. Given the adverse outcomes being reported in adulthood in people who were diagnosed with T2D in youth, these data highlight the need for on-going study to address a potential major public health problem in the US and worldwide. Article page 86 ▶ Cardiac Biomarkers in Youth with Type 2 Diabetes Mellitus: Results from the TODAY StudyThe Journal of PediatricsVol. 192PreviewTo examine cardiac biomarkers over time in youth-onset type 2 diabetes, and relate serum concentrations to cardiovascular disease risk factors, and left ventricular structure and function. Full-Text PDF