Younger Cohorts Research Articles

Age, period, cohort effects in trends of depressive symptoms among middle-aged and older Chinese adults.

To investigate the effects of age, period, and cohort on the trends of depression; and to examine the influence of these three temporal effects on residential disparities in depression. Using data from the China Health and Retirement Longitudinal Study (CHARLS) during 2011 to 2020, involving 77,703 respondents aged 45 years old and above. The measurement of depressive symptoms was the score of 10-question version of the Center for Epidemiologic Studies Depression Scale (CES-D 10). The hierarchical age-period-cohort cross-classified random effects models were conducted to examine trends in depressive symptoms related to age, period and cohort. CES-D scores increased with age and slightly decreased at older age. The cohort trends mostly increased except for a downward trend among those born in 1950s. As for the period effect, CES-D scores decreased gradually from 2011 to 2013 followed by a upward trend. Rural residents were associated with higher level of depression than those live in urban area. These residence gaps in depression enlarged before the age of 80, and then narrowed. The urban-rural disparities in CES-D scores gradually diminished across cohorts, while the corresponding period-based change in urban-rural gaps was not significant. When age, period, cohort factors are considered, the age effects on depression dominated, and the period and cohort variations were relatively small. The residence disparities in depression reduced with successive cohorts, more attention should be paid to the worsening depression condition of younger cohorts in urban areas.

Can the improvements in human capital quality mitigate the negative impact of ageing on growth? Evidence from selected EU countries

AbstractMost long‐term GDP projections in developed countries expect a substantial decline in GDP growth rates over time. The main factor behind it is demographic changes, especially the decreasing working‐age population. We argue that these projections do not consider improvements in the quality of the human capital, which may, at least to some extent, mitigate the effects of the negative demographic shock. We start with a simple observation—the skills of younger age cohorts are higher than of older cohorts. Assuming that the current level of skills will be obtained also by the generations which will enter the labour market in the future, the average level of skills among the working‐age population will increase. Trying to catch this effect, we use the Programme for the International Assessment of Adult Competencies standardised test results to create an aggregate human capital measure, the average skill level of the work force, for 18 European Union countries and project it until 2040. We show that on average at least one sixth of the negative impact of the shrinking of the working‐age population can be offset by the increase in the quality of human capital and that this number can increase to three quarters in a less conservative scenario.

The Transformation of Traditional Peasants: An Age–Period–Cohort Analysis of the Modernity of Peasants in China

Using the data of Chinese General Social Survey from 2010 to 2018, this study measured the modernity of Chinese peasants from four dimensions: equality and autonomy, positive attitude, general confidence, and open-mindedness. Hierarchical age–period–cohort models were introduced to assess the effect of age, period, and cohort on modernity and to further explore the heterogeneities in the effect of education and off-farm work experience on modernity among various birth cohorts. Age effects consistently show significance, with the level of individual modernity decreasing as age increases. However, the rate of decline gradually slows down. Period effects are generally significant and contribute to the advancement of modernity. Cohort effects are significant in most cohorts. The modernity of peasants born between 1941 and 1960 show a consistent decline, reaching its lowest point in the cohort 1961–1970 and then increasing steadily among those born after 1970. Possible explanations were proposed from the perspective of changes in the land property system and household registration system in China. We also found that the positive effect of education is stronger for younger cohorts, whereas the positive effect of off-farm experience is stronger for older cohorts. This study enriches Inkeles’s research on individual modernization and reveals the transformation process of traditional peasants in developing countries.

Interplay of mobile phone dependency and catch-up sleep in South Korean youth: A seven-wave study of two nationally representative cohorts

This study investigated the reciprocal loop between catch-up sleep and mobile phone dependency from late childhood to late adolescence, distinguishing between inter-individual and intra-individual variations. Data from two nationally representative South Korean birth cohorts (N = 4,729, 48.8% female) were collected annually, assessing participants seven times from Grade 4 to Grade 10 or Grade 7 to post-high school. Findings from a cross-lagged panel model (CLPM) and a random-intercept CLPM showed that students who were more dependent on their mobile phones, either compared to others or to their own averages, were likely to report greater catch-up sleep from Grade 4 through Grade 7 in the younger cohort and from Grade 7 through Grade 10 in the older cohort. Likewise, students with greater catch-up sleep, compared to others or to their own averages, tended to rely more on their mobile phones from Grade 4 to Grade 5 in the younger cohort and from Grade 7 to Grade 8 in the older cohort. The CLPM findings further revealed that in the younger cohort, students with higher mobile phone dependency than their peers were more likely to increase catch-up sleep from Grade 7 to Grade 8, and in the older cohort, from Grade 10 to Grade 11. Similarly, higher catch-up sleep led to increased mobile phone dependency from Grade 9 to Grade 10 in the younger cohort, and from Grade 12 to the year post-high school in the older cohort. These patterns suggest consistent tendencies at both inter- and intra-adolescent levels.

Control-matched octo/nonagenarian outcomes in acute basilar artery occlusions treated with mechanical thrombectomy-analysis of the PC-SEARCH thrombectomy registry.

Age is often used as a predictor in determining outcomes in large vessel occlusions treated with mechanical thrombectomy. However, limited data exist for octo/nonagenarian outcomes compared to younger individuals in acute basilar artery occlusions treated with thrombectomy. Patient data were obtained from the PC-SEARCH Thrombectomy Registry which consists of 444 acute basilar artery occlusions treated with mechanical thrombectomy. Individuals were dichotomized based on age (>80 and ≤80 years old). Primary outcome was defined as modified Rankin Scale of 0-3 at 90 days. Logistic and multivariate regression, as well as control-matched analysis, were performed. There were 373 and 71 patients in the younger and older cohorts, respectively. Gender, ethnicity, smoking status, atrial fibrillation, and coronary artery disease were noted to be significantly different between cohorts. At 90 days, 178 (47.7%) and 23 (32.4%) patients achieved primary outcome at 90 days (p = 0.02), however, after controlling for potentially confounding factors this association lost significance (OR 0.50 95% CI 0.24-1.05; p = 0.07). There were 84 patients included in the control matched analysis and demonstrated no significant differences on multivariate analysis between cohorts (OR 0.68 95% CI 0.25-1.84; p = 0.45). Octa/nonagenarians presenting with an acute basilar artery occlusion treated with mechanical thrombectomy can achieve acceptable rates of favorable functional outcomes compared to younger individuals with similar baseline demographic and stroke characteristics.

A Cross-Sectional Study of Measles-Specific Antibody Levels in Australian Blood Donors-Implications for Measles Post-Elimination Countries.

Passive immunisation with normal human immunoglobulin (NHIG) is recommended as post-exposure prophylaxis (PEP) for higher-risk measles contacts where vaccination is contraindicated. However, the concentration of measles-specific antibodies in NHIG depends on antibody levels within pooled donor plasma. There are concerns that measles immunity in the Australian population may be declining over time and that blood donors' levels will progressively decrease, impacting levels required to produce effective NHIG for measles PEP. A cross-sectional study of Australian plasmapheresis donors was performed using an age-stratified, random sample of recovered serum specimens, collected between October and November 2019 (n = 1199). Measles-specific IgG antibodies were quantified by ELISA (Enzygnost anti-measles virus IgG, Siemens), and negative and equivocal specimens (n = 149) also underwent plaque reduction neutralisation testing (PRNT). Mean antibody levels (optical density values) progressively decreased from older to younger birth cohorts, from 2.09 [±0.09, 95% CI] to 0.58 [±0.04, 95% CI] in donors born in 1940-1959 and 1990-2001, respectively (p < 0.0001). This study shows that mean measles-specific IgG levels are significantly lower in younger Australian donors. While current NHIG selection policies target older donors, as younger birth cohorts become an increasingly larger proportion of contributing donors, measles-specific antibody concentrations of NHIG will progressively reduce. We therefore recommend monitoring measles-specific antibody levels in future donors and NHIG products in Australia and other countries that eliminated measles before the birth of their youngest blood donors.

Relationship between epicardial adipose tissue and coronary atherosclerosis by CCTA in young adults (18–45)

ObjectiveEpicardial adipose tissue (EAT) is implicated in the pathogenesis and progression of coronary artery disease (CAD). Limited data exists on the interplay between EAT and atherosclerosis in young individuals. Our study aims to explore the relationship between EAT and CAD in a young cohort. MethodsAll young (18–45 years) patients without prior CAD, referred for coronary computed tomography angiography (CCTA) from 2016 to 2022 were included. EAT volume and coronary artery calcium (CAC) were calculated from dedicated non-contrast scans. Coronary plaque presence, extent, and volume were quantified from CCTA. Multivariable logistic regression models for the presence of CAD, defined as any coronary atherosclerosis, were performed. ResultsOverall, 712 patients (39±4.8 years, 54 % female) with 45 % Hispanic, and 21 % non-Hispanic Black were included. Patients with CAD had higher EAT volume than those without (80.80 mL ± 36.00 vs 55.16 mL ± 27.92; P < 0.001). In those with CAC=0, higher EAT was associated with the presence of CAD compared to lower EAT volume (P < 0.001). An EAT volume >76 mL was associated with higher CAC (P < 0.001), segment involvement score (P < 0.001), and quantitative total, non-calcified, and low-attenuation plaque volumes (P < 0.002). At multivariable analysis, EAT volume (per 10 mL, OR: 1.21; 95 %CI: 1.12–1.30; P < 0.0001) was independently associated with the presence of CAD. ConclusionIn a diverse cohort of young adults without history of CAD and undergoing a clinically indicated CCTA, EAT volume was independently associated with the presence of CAD. Our findings highlight EAT potential as a novel marker for CAD risk-assessment and a potential therapeutic target in young patients.

Examining the impact of polyfluoroalkyl substance exposure on erythrocyte profiles and its related nutrients: Insights from a prospective study on young Taiwanese

Per- and polyfluoroalkyl substances (PFAS) constitute a group of synthetic chemicals extensively utilized across various commonplace products. PFAS are known to have various toxic effects on human health. The relationship between PFAS exposure and erythrocytes has been a subject of interest in epidemiological research, but so far, only limited cross-sectional studies have investigated. Additionally, the role of erythrocyte related nutrition indicators on PFAS-induced changes in erythrograms has not been explored. To fill these knowledge gaps, we launched a longitudinal study over a decade, tracking 502 adolescents and young adults aged 12 to 30 from the YOung TAiwanese Cohort (YOTA). Our analysis encompassed 11 types of plasma PFAS, as well as erythrograms and serum levels of ferritin, transferrin saturation, vitamin B12, and folate. Our examination unveiled positive associations between specific average levels of PFAS compounds, including linear perfluorooctanoic acid (PFOA), branched perfluorooctane sulfonic acid (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonic acid (PFHxS), and transferrin saturation. Furthermore, linear PFOA and both linear and branched PFOS were negatively correlated with vitamin B12 levels. Specifically, we observed that the average linear PFOA demonstrated positive correlations with mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH), while average PFNA also exhibited positive associations with hemoglobin (Hb) and hematocrit (Hct) in a multiple linear regression model. Subsequent analysis revealed noteworthy interactions between vitamin B12 and PFNA, as well as folate and PFNA, in the context of their impact on Hb, Hct, and PFNA relationships. Additionally, an interaction with transferrin saturation was identified in the correlation between Hct and PFNA. These findings suggest a plausible link between PFAS exposure and erythrograms among young populations, underscoring the potential involvement of iron status, vitamin B12, and folate in this association. Further studies are imperative to elucidate the precise effects of PFAS on erythrocyte in human subjects.

Religious rebound, political backlash, and the youngest cohort: understanding religious change in Turkey

Abstract We distinguish two streams of theory that dominate explanations of religious change: cohort-based cumulative decline theory, which emphasizes small and ongoing declines in individual religiosity accruing across generations; and political backlash theory, which emphasizes period- and identity-based changes due to the politicized meaning of religion. Notably, Muslim countries have largely been excluded from a recent wave of quantitative research on individual-level religious change, implicitly continuing an assumption that Islamic societies require different theoretical concepts. We deploy both theories to examine religious identity and behavior over multiple decades in Turkey, a Muslim-majority country with recent social conflict over religion. Utilizing age-period-cohort interaction models, our results suggest minimal evidence for a cohort-based process in Turkey, in contrast to that observed in Western countries. Rather, a political transformation—the politicization of religion through the rise of Turkey’s AKP (Justice and Development Party) and President Erdogan—is most salient to Turkish religious change. We introduce two concepts to backlash theory—identity updating and performance signaling—to show how different dimensions of individual religiosity respond to different politicized contexts. These findings extend our understanding of religious change beyond the Western context, with further implications for theorizing political backlash and cohort-based processes.

Sleep Problems and Gambling Disorder: Cross-Sectional Relationships in a Young Cohort.

To investigate the potential association between gambling disorder and symptoms of sleep problems (including insomnia and excessive daytime sleepiness). It was hypothesised that, compared to controls, individuals with gambling disorder would have significantly greater disturbance of sleep, as indicated by increased scores in: (1) sleep items on the Hamilton Anxiety Rating Scale (HAM-A) and Hamilton Rating Scale for Depression (HAM-D); (2) total score on the HAM-A and HAM-D; and (3) the Epworth Sleepiness Scale (ESS). Secondary analysis of previously published data from 152 young adults, aged 18-29 years. Individuals were stratified into three groups: controls, those at risk of gambling disorder, and those with gambling disorder. One-way ANOVAs with post-hoc tests were conducted to determine whether groups differed significantly in sleep item scores and total scores of the HAM-A and HAM-D, and the ESS. HAM-D scale insomnia item scores were significantly higher in the disorder group, when compared to controls, this being particularly marked for middle and late insomnia. The HAM-A item score indicated significantly worse sleep quality in the disorder group, compared to at risk and control groups. Total HAM-A and HAM-D scores were significantly higher in the disorder group, but ESS scores did not differ significantly. Measures of disruptions in sleep were significantly higher in gambling disorder than controls. Anxiety and depressive symptom severity was also significantly higher in the gambling disorder group. Further research could have implications for identification and treatment of sleep disorders and psychiatric comorbidities in gambling disorder.

Chronic Myeloid Leukemia in Adolescents and Young Adults: Clinicopathological Variables and Outcomes.

Adolescents and young adults (AYAs) diagnosed with chronic myeloid leukemia (CML) constitute a significant demographic group, particularly in regions with youthful populations like Qatar. Despite the global median age of CML diagnosis being 65 years, Qatar's age distribution reflects a younger cohort. This study investigates whether AYAs with CML exhibit distinct clinicopathological characteristics or outcomes compared to older age groups. A total of 224 CML patients were enrolled, including 114 AYAs (defined as ages 15 through 39). Demographic and clinical parameters, including gender, BMI, BCR-ABL1 transcript type, white blood cell (WBC) count, hemoglobin level, platelet count, and spleen size, were compared between AYAs and older patients. Prognostic scoring systems (Sokal, Hasford, EUTOS, and ELTS) and molecular response rates (MMR and DMR) were also evaluated. AYAs demonstrated higher WBC counts at diagnosis (median 142.3 vs. 120; p = 0.037) and lower hemoglobin levels (10.5 vs. 11.40; p = 0.004) compared to older patients. Spleen size was significantly larger in AYAs (18.8 vs. 15.5; p = 0.001). While AYAs showed better prognostic scores by Sokal and Hasford criteria, EUTOS and ELTS scores indicated comparable risk stratification. However, AYAs exhibited lower rates of MMR (56.7 vs. 73.4%; p = 0.016) and achieved MMR at a slower pace (median time 130 vs. 103 months; p = 0.064). Similarly, the percentage of DMR was lower in AYAs (37.1 vs. 46.8%; p = 0.175). Despite their younger age, AYAs with CML displayed poorer prognoses compared to older patients. These findings underscore the importance of tailored management strategies for AYAs with CML to optimize outcomes in this distinct patient population. AYAs are underrepresented in CML studies and risk scores, so this is the focus of this study.

Anticholinergic burden and health-related quality of life among adult patients in a resource-limited setting: a cross-sectional study.

Anticholinergic medications are now widely acknowledged for their unfavorable risk-to-benefit profile owing to their adverse effects. Health-related quality of life (HRQoL) is commonly regarded as a crucial person-centered outcome. This study aimed to investigate the association between anticholinergic burden and HRQoL in hospitalized and ambulatory patients seen in Ethiopia. This cross-sectional study utilized a questionnaire and medical records to collect data from a convenience sample of adult patients attending both inpatient wards and ambulatory clinic of University of Gondar Comprehensive Specialized Hospital between April and September 2022. Anticholinergic burden was measured by anticholinergic cognitive burdens scale (ACBS), while HRQoL was measured using EQ5D-index (Euroqol-5 dimensions-5-Levels index) and EQ5D-VAS (visual analogue scale). Linear regression was used to assess the influence of high anticholinergic burden (ACBS score ≥ 3) on EQ5D-index and EQ5D-VAS, with adjustments made for sociodemographic and clinical confounders. A total of 828 patients participated in this study (median (IQR) age was 45.0 (30, 60) and 55.9% were female). On multiple linear regression analysis, high anticholinergic burden was associated with a statistically significant decline in HRQoL, as evidenced by reductions in both EQ5D index (- 0.174 (- 0.250, - 0.098)) and EQ5D-VAS scores (- 9.4 (- 13.3, - 5.2)). A significant association between high anticholinergic burden and diminished HRQoL was found among a relatively younger cohort in a resource-limited setting, even after adjustment for important confounding variables. Clinicians should be cognizant of the cumulative impact of anticholinergic burden on HRQoL outcomes and strive to minimize anticholinergic burden.

A generation divided: The politics of Generation X

AbstractGeneration X often receives less attention in generational analysis due to its perceived lack of distinctiveness compared to preceding and succeeding generations in the contemporary United States. Politically, there is little justification for distinguishing Generation X as it is commonly defined, yet it harbors significant political divergence between its older and younger cohorts. In terms of partisanship, ideology, and public policy preferences, Generation X is markedly divided, essentially comprising two distinct political generations. Generation X can thus be viewed as the in‐between generation representing the political dividing line between young and old. The dividing point is the birth year of 1973. Due to the considerable differences in the political climate during their formative years, those Gen Xers born before 1973 lean considerably more conservative and Republican than those born in 1973 and afterward.Related ArticlesFisher, Patrick. 2020. “Generational Replacement and the Impending Transformation of the American Electorate.” Politics &amp; Policy 48(1): 38–68. https://doi.org/10.1111/polp.12340.Shaykhutdinov, Renat. 2019. “Socialization, Rationality, and Age: Generational Gaps and the Attitudes toward the Chechen War in Russia.” Politics &amp; Policy 47(5): 931–55. https://doi.org/10.1111/polp.12323.Stockemer, Daniel. 2016. “Is the Turnout Function in Democracies and Nondemocracies Alike or Different?” Politics &amp; Policy 44(5): 889–915. https://doi.org/10.1111/polp.12174.

Younger Older Americans and Sarcopenic Obesity: The Moderating Role of Living Alone.

Previous studies have indicated that compared to older adults, younger older adults (e.g., baby boomers) are more susceptible to obesity, but their risk decreases as they age. However, there is a lack of research on how individuals experience sarcopenic obesity, which increases in later life and is a mortality risk factor. This study examined how younger cohorts of older Americans and their demographic traits are related to sarcopenic obesity. Generalized estimating equations were used to analyze participants aged 65 years and older, stratified by sex using data from the 2006-2016 Health and Retirement Study, with survey weights (n = 2,896 men and n = 4,268 women). The findings indicate that the youngest cohort (born between 1948 and 1953) had greater odds of sarcopenic obesity than older cohorts (born before 1931). However, the youngest cohort did not have significantly different risks from those born between 1931 and 1947. Unexpectedly, the youngest cohort of older women living alone tended not to have sarcopenic obesity compared to the older cohorts living alone. These results remained significant even after adjusting for various covariates, including marital status, race, education level, wealth, and other factors. This paper contributes to the existing literature on population health and demographic change in 2 ways. First, the risk of sarcopenic obesity is higher among younger cohorts of older Americans relative to older cohorts (born before 1931). Second, living alone may not necessarily be considered a worse health condition, particularly for younger female cohorts.

The Future Process of Japan’s Population Aging: A Cluster Analysis Using Small Area Population Projection Data

Japan’s population aging is the most advanced in the world today. No nationwide study has been conducted using small area population projection data on Japan’s aging population. This is because such projection data was unavailable for Japan before the 2016 launch of the website ‘The Web System of Small Area Population Projections for the Whole Japan’ (SAPP for Japan). SAPP for Japan opened the small-area and long-term projected population of Japan for the first time on the World Wide Web. The purpose of this study is to quantitatively analyze the future aging process using data from the SAPP for Japan and, based on this analysis, to attempt to present the standard aging process that developed countries will experience after the demographic transition, taking advantage of the fact that Japan has the most aged population in the world. Subsequently, a non-hierarchical cluster analysis was performed using two statistics on aging: the elderly population proportion and the elderly population change index, and the small areas were classified into seven clusters. Furthermore, this study examined the demographic and geographical features of the clusters, introduced a new concept of the stage in the population aging process, and analyzed the relationship between the features and the stages. To conclude, the following findings were obtained regarding the future process of Japan’s population aging. In each area of Japan, first, the total population begins to decline, second, the elderly population begins to decrease, and finally, its proportion begins to decrease. These stage shifts generally proceed earlier in areas with a higher elderly population proportion and are attributed to the reduced size of younger cohorts owing to long-term fertility decline. This process would be the norm in many developed countries after the demographic transition.

Effect of elevated depressive symptoms during adolescence on health-related quality of life in young adulthood-a six-year cohort study with repeated exposure measurements.

Depression is a major contributor of young people's burden of disease. In this study we aim to estimate the effect of elevated depressive symptoms on physical health-related quality of life. We used self-reported information from the prospective BELLA cohort study, which included adolescents selected from the general population in Germany. The baseline assessment (2003-2006) and the 1-, 2-, and 6-year follow-up waves provide the data basis. The baseline study population consisted of 1,460 adolescents between the ages of 12 and 17 who, according to their caregivers, did not suffer from depression. The primary outcome, as measured by the physical component score (PCS) of the SF-36 at a 6-year follow-up (range: 0-100), is physical health-related quality of life. The exposure of interest is depressive symptoms, as measured by the Center for Epidemiological Studies Depression Scale for Children (CES-DC) at baseline, 1-year follow-up and 2-year follow-ups (range: 0-60). We dichotomized the exposure into subthreshold (≤15) and elevated depressive symptoms (>15). For the main analyses we considered a cumulative index for elevated depressive symptoms across the three time points (range: 0-3). Considered confounders are sex, age, socioeconomic status, migrant background, social support, anxiety symptoms, physical activity, chronic diseases, and sleeping problems. We used multiple imputation to account for missing values. Within each imputed dataset, we applied inverse probability weighting (IPW) to estimate the effect of the cumulative index for elevated depressive symptoms at baseline, 1- and 2-year follow-up on physical health-related quality of life at 6-year follow-up. We derived 95% confidence intervals by bootstrapping. After adjusting with IPW, the effect of the cumulative index per one unit increase of elevated depressive symptoms on the physical component score was -1.71 (95% CI: -3.51 to -0.04). The adjusted effect estimates of single exposure of elevated depressive symptoms on physical health-related quality of life were -0.83 (95% CI: -3.69 to 1.87) at baseline, -2.96 (95% CI: -4.94 to -0.52) at 1-year follow-up and -1.32 (95% CI: -3.85 to 1.15) at 2-year follow-up. Findings suggest that elevated depressive symptoms during adolescence decrease physical health-related quality of life in young adulthood.

Mental well-being of children and adolescents during COVID-19: evidence from the Italian context and possible future developments.

The article aims to discuss the increased emergence of mental health problems among children and adolescents, as an outcome of the COVID-19 pandemic.The results of a research study conducted among various professionals, such as psychiatrists and psychologists specialized in childhood and adolescence, are presented. The study, which uses both qualitative and quantitative methods, investigates the main consequences of the physical social distancing measures undertaken by the Italian government during the pandemic. The results are in line with the main evidence highlighted by international research and underline the particularly negative effects of the pandemic emergency on the mental health of minors. It reports how the limitation of intersubjective relationships and the forced digitalization of relationships has triggered or caused the emergence of multiple and varied disorders of the psyche, also linked to the area of reference (e.g., metropolitan, urban o remote areas), the socio-economic and cultural fragility of families, as well as the presence of previous mental issues within them. Finally, the research emphasizes how the understanding and management of the psychic health of these population groups, also from a health organization point of view, will be crucial to address the medium and long-term effects of such emerging issues among younger cohorts.

Intergenerational Support and the Financial Strategies of Young Homebuyers in Shanghai

ABSTRACT While homebuying has become central to the economic security and life-course transitions of younger Chinese adult cohorts, affordability has become an increasing obstacle. With individual savings and housing loans fading as means of achieving homeownership, intergenerational transfers have acquired renewed status. This paper addresses the agency of young people and their families in negotiating adverse housing market conditions. It draws on qualitative interviews with young-adults in Shanghai that explore intergenerational transfers and the strategies deployed to finance homebuying and in developing long-term financial arrangements. Our research stresses intergenerational collaboration in how young people navigate owner-occupation as well as how features of families and housing financialization combine to shape the behaviour of young people in the housing market. Shanghai represents a challenging market for young homebuyers, but provides insights on how family-support can shape housing systems and pathways in various housing contexts.

Inequalities in disability

Abstract Prevalence of disability and receipt of disability benefits have steadily increased among the UK’s working-age population in recent years. We examine inequalities in disability and its prevalence between educational groups, year of birth cohorts, regions and genders in the UK. Our analysis reveals significant disparities in disability rates across groups. In particular, disability is strongly related to education: those with lower levels of education have similar disability rates to those with degrees who are decades older than them. These gaps in disability rates open up early on in the life cycle, and while the prevalence of poor physical health increases steadily with age, we see the prevalence of poor mental health rising particularly fast among younger cohorts. These patterns in early life may have profound future implications for physical health and longevity. These results suggest that disability may be a key driver of inequalities across the life cycle.

R(+) Propranolol decreases lipid accumulation in hemangioma-derived stem cells.

Infantile hemangioma (IH) is a benign vascular tumor that undergoes an initial rapid growth phase followed by spontaneous involution. A fibrofatty residuum remains in many tumors and often necessitates resection. We recently discovered that R(+) propranolol, the non-β blocker enantiomer, inhibits blood vessel formation of IH patient-derived hemangioma stem cells (HemSC) xenografted in mice. HemSC are multipotent cells with the ability to differentiate into endothelial cells, pericytes, and adipocytes. We investigated how R(+) propranolol affects HemSC adipogenic differentiation and lipid accumulation, in vitro and in a preclinical murine model for IH. We conducted a 10-day adipogenesis assay on 4 IH patient-derived HemSCs. Oil Red O (ORO) staining was used to identify the onset and level of lipid accumulation in HemSC while quantitative real-time polymerase chain reaction was conducted to determine the temporal expression of key factors implicated in adipogenesis. 5-20µM R(+) propranolol treatment was added to HemSC induced to undergo adiogenesis for 4 and 8 days, followed by quantification of lipid-stained areas and transcript levels of key adipogenic factors. We immunostained for lipid droplet-associated protein Perilipin 1 (PLIN1) in HemSC-xenograft sections from mice treated with R(+) propranolol and quantified the area using ImageJ. We found that different patient-derived HemSC exhibit a robust and heterogenous adipogenic capacity when induced for adipogenic differentiation in vitro. Consistently across four IH patient-derived HemSC isolates, R(+) propranolol reduced ORO-stained areas and lipoprotein lipase (LPL) transcript levels in HemSC after 4 and 8 days of adipogenic induction. In contrast, R(+) propranolol had no significant inhibitory effect on transcript levels encoding adipogenic transcription factors. In a pre-clinical HemSC xenograft model, PLIN1-positive area was significantly reduced in xenograft sections from mice treated with R(+) propranolol, signifying reduced lipid accumulation. Our findings suggest a novel regulatory role for the R(+) enantiomer of propranolol in modulating lipid accumulation in HemSC. This highlights a novel role of R(+) propranolol in the involuting phase of IH and a strategy to reduce fibrofatty residua in IH. Propranolol is the mainstay treatment for infantile hemangioma (IH), the most common tumor of infancy, but its use can be associated with concerning β-blocker side effects.R(+) propranolol, the enantiomer largely devoid of β-blocker activity, was recently shown to inhibit endothelial differentiation of hemangioma-derived stem cells (HemSC) in vitro and reduce blood vessel formation in a HemSC-derived xenograft murine model of IH. R(+) propranolol inhibits lipid accumulation in HemSC in vitro.R(+) propranolol does not affect mRNA transcript levels of key adipogenic transcription factors in differentiating HemSC in vitro.R(+) propranolol reduces lipid accumulation in a pre-clinical xenograft murine model of IH. The R(+) enantiomer of propranolol could be advantageous in terms of reduction in β-adrenergic side effects and fibrofatty tissue formation in the involuting phase of IH.Less fibrofatty residua might reduce the need for surgical resection.Disfigurement and associated psychosocial impacts might be improved in this young patient cohort.