Young Tuberculosis Patients Research Articles

Nutrition literacy mediates the relationship between self-efficacy and eating behavior in young tuberculosis patients: A cross-sectional study

ObjectiveTo assess the associations between self-efficacy, nutrition literacy and eating behavior, and to examine if nutrition literacy mediates the relationship between self-efficacy and eating behavior in young tuberculosis patients. MethodsThis cross-sectional study used a convenience sampling strategy to select 230 young tuberculosis patients at the Second Hospital of Nanjing (Public Health Medical Center of Nanjing), China, from June 2022 to August 2022. The data were collected using a demographic data form, the Eating Behavior Scale, the Food and Nutrition Literacy Questionnaire and the Tuberculosis Self-Efficacy Scale. Descriptive statistics, Pearson bivariate correlation analysis, Pearson partial correlation analysis, hierarchical multiple regression, and mediation analysis were conducted in the study. ResultsThe mean self-efficacy score for young tuberculosis patients was 92.56 (SD = 9.89, range = 21 ∼ 105). The average nutrition literacy score for young tuberculosis patients was 68.24（SD = 6.75, range = 0 ∼ 100). The bivariate correlation analysis and partial correlation analysis found that self-efficacy was positively correlated with nutrition literacy (P < 0.01). The regression analysis showed that self-efficacy (F = 5.186, β = 0.233, P < 0.001)and nutrition literacy (F = 7.749, β = 0.545, P < 0.001) significantly predicted eating behavior. The three dimensions of nutrition literacy including nutritional knowledge (mediation effect ratio = 13.1%, 95% CI = − 0.089; −0.005), preparing food (mediation effect ratio = 17.4%, 95 %CI = 0.011; 0.077) and eating (mediation effect ratio = 54.7%, 95 %CI = 0.070; 0.192) mediated the relationship between self-efficacy and eating behavior in young tuberculosis patients. ConclusionNutrition literacy mediatedtherelationship between self-efficacy and eating behavior. To promote healthy eating behavior among young tuberculosis patients, interventions aimed at improving self-efficacy and nutrition literacy should be conducted.

Profile and treatment outcomes among young patients with tuberculosis aged 15–24 years in Faridabad district of Haryana, India

ObjectiveThis study examined profile and treatment outcomes of young patients with tuberculosis (TB) registered at a district TB centre under the National TB Elimination Programme in Faridabad district of Haryana...

Preparing Short Message Service Reminders to Improve Treatment Adherence among Tuberculosis Patients in Sleman District, Indonesia.

Background:Modern tuberculosis (TB) treatment approaches require innovative adherence strategies.Objectives:This study aimed to explore the feasibility of using short message service (SMS) reminders through mobile phones to improve treatment adherence among TB patients.Materials and Methods:An exploratory sequential design was applied; initially, qualitative data collection was conducted among TB patients and TB program officers. A content analysis was done and messages were then developed. The messages were pretested using focus group discussions (FGDs), and a quantitative method using quasi-experiment on 120 TB patients. All the patients received a standard directly observed therapy short reminder, but only intervention group received daily SMS reminders (n = 60), the data were then analyzed using logistic regression.Results:Reminder messages can be sent directly to young TB patients or indirectly to the relatives of elderly patients. There are four phases of emotional states, which TB patients go through during treatment starting with disappointment and desperation after being diagnosed, grievance during the initiation of treatment, high and then low desire to follow treatment. Reminder messages aimed at improving treatment adherence should correspond to those conditions and motivate, inform, and facilitate TB patients to overcome all the obstacles during treatment. SMS reminders should also be short, informal, and easy to understand. Treatment adherence was significantly higher among the intervention group compared to the control group (odds ratio = 10.73) after controlling for demographics, accessibility, and adverse drug reaction.Conclusions:SMS through mobile phone is a feasible form of media to remind TB patients and to improve adherence to treatment in low-resource facilities.

Correlation analysis of the mental state and social support among young patients with tuberculosis

Objective To investigate the status and influence factors on mental health among young stuberculosis patients, and explore the correlation between mental health and social support, so as to provide scientific basis for the development of interventions. Methods A total of 200 young tuberculosis patients, aged ≤40 year, were selected in Xuzhou Infectious Hospital from May 2015 to August 2016, and investigated by self-designed general information questionnaire, Symptom Checklist (SCL-90) and Social Support Rating Scale (SSRS) . The correlations were analyzed between mental health and social support. Results Compared with 1986 and 2006 national norm, the sum score of SCL-90 was (147.34±46.39) for involved youth (t=5.298, 5.280; P<0.05) . In multiple regression analysis, the main influence factors included educational level, annual income for score of SCL-90. The score of SCL-90 was negatively correlated with scores of social support, subjective support and degree of support utilization (r=-0.232, -0.221, -0.407; P<0.05) . Conclusions The mental health status of young patients with tuberculosis is poor, and social support is closely related to mental health. Medical staff should timely carry out psychological intervention measures to improve the mental health and promote the rehabilitation. Key words: Tuberculosis, pulmonary; Mental health; Social support

The association between tuberculosis and the development of insulin resistance in adults with pulmonary tuberculosis in the Western sub-district of the Cape Metropole region, South Africa: a combined cross-sectional, cohort study

BackgroundThe existence of a bi-directional relationship between tuberculosis (TB) and insulin resistance (IR)/diabetes has been alluded to in literature. Although diabetes has been linked to increased tuberculosis risk, the relationship between tuberculosis as a causative factor for IR remains unclear. The study aimed to determine if an association existed between tuberculosis and IR development in adults with newly diagnosed pulmonary tuberculosis at baseline. It was additionally aimed to document changes in IR status during TB follow-up periods.MethodsThis cross-sectional study evaluated ambulatory participants at baseline for IR prevalence via anthropometry, biochemistry and diagnostic IR tests [homeostasis model assessment-IR (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI)]. A prospective cohort sub-section study was additionally performed on approximately half of the baseline study population, who were followed-up at two and five months whilst on tuberculosis treatment. Summary statistics, correlation co-efficients and appropriate analysis of variance were used to describe and analyse data. Participants were excluded if they presented with other forms of tuberculosis, were HIV-positive, obese or had any pre-disposing IR conditions such as diabetes or metabolic syndrome.ResultsFifty-nine participants were included from August 2013 until December 2014 (33.95 ± 12.02 years old; 81.4% male). IR prevalence was 25.4% at baseline, determined by a calculated HOMA-IR cut-off point of 2.477. Patients with IR were younger (p = 0.04). Although the difference between IR levels in participants between baseline and follow-up was not significant, a decrease was observed over time. The majority of participants (61.0%) presented with a normal BMI at baseline. Mean baseline values of fasting glucose were within normal ranges (4.82 ± 0.80 mmol/L), whereas increased mean CRP levels (60.18 ± 50.92 mg/L) and decreased mean HDL-cholesterol levels (males: 0.94 ± 0.88 mmol/L; females: 1.14 ± 0.88 mmol/L) were found.ConclusionsThe study found an association between tuberculosis and IR development in newly diagnosed pulmonary tuberculosis patients. Although not significant, IR levels decreased over time, which could be indicative of a clinical improvement. A high prevalence of IR amongst young tuberculosis patients therefore highlights the need for early identification in order to facilitate a reversal of IR and prevent possible IR-related complications.

The experiences of high school students with pulmonary tuberculosis in China: a qualitative study.

BackgroundClustered tuberculosis (TB) still occurred nationally in Chinese schools every year, where high school students patients accounts for the highest proportion. These young TB patients are in a critical period of physical and psychological growth. Research on their illness experience and analysis of underlying causes remains blank. The purpose of this study is to explore the overall illness experience of Chinese high school TB patients and to investigate the individual and social causes of such experience.MethodsTwenty-two high school TB patients in a certain county of Shaanxi province were interviewed in-depth twice when initial diagnosed and during intermediate treatment periods. Interview data were analyzed by framework approach.ResultsThe high school TB patients worried about interruption of studies rather than the disease. They generally showed a lack of awareness of tuberculosis, were highly dependent on parents, and received assistance from teachers and students during the treatment. Most of them did not show obvious stigma.ConclusionThe unique education system and sociocultural factors in China are the root of special illness experience of high school TB patients. Huge pressure in college entrance examination leads sick students to worry about interruption of studies more than the disease itself. Their serious lack of awareness of TB, caused by the ignorance of school, parents and the students, becomes the biggest obstacle to timely diagnosis and treatment. Whether high dependence on parents is conducive to disease recovery varies with each individual. Meanwhile, patients’ weak stigma could play a positive role in disease recovery. Educational and medical institutions should develop more effective TB control strategies based on these factors.

Genotypic characterization and historical perspective of Mycobacterium tuberculosis among older and younger Finns, 2008–2011

The Mycobacterium tuberculosis genotypes obtained from elderly Finns were assessed and compared with those obtained from younger Finns to comprehend the epidemiology of tuberculosis (TB) in Finland. From 2008 to 2011, a total of 1021 M. tuberculosis isolates were characterized by spoligotyping and 15-locus mycobacterial interspersed repetitive units–variable number tandem repeat typing. In total, 733 Finnish-born cases were included in the study, of which 466 (64%) were born before 1945 (older Finns). Of these, 63 (14%) shared an M. tuberculosis genotype with foreign-born or younger Finnish cases (born after 1945), and 59 (13%) shared a genotype with older Finnish cases. Eighty-five per cent had a unique genotypic profile while 70% belonged to T or Haarlem families, suggesting that ongoing transmission is infrequent among young and elderly Finns. Simultaneous reactivation of TB among older Finns was the most likely cause for clustering. As most isolates belonged to Haarlem or T, Finland was most likely affected by a similar TB epidemic at the beginning of the twentieth century as that seen in Sweden and Norway. Younger Finns were significantly more likely to be clustered (56% versus 27%, p <0.001), have pulmonary TB (87% versus 71%, p <0.001) and to be sputum smear positive (57% versus 48%, p <0.05) indicating that the risk of TB transmission from younger Finns is likely to be larger than from older Finns. The M. tuberculosis isolates from elderly Finns were associated with dominant lineages of the early twentieth century and differed from the heterogeneous lineages found among younger TB patients. Additionally, younger TB patients were more likely to transmit TB than elderly Finns.

Increasing Tuberculosis Notification Rates Among Young Adults are Not Associated with Migration in Da Nang, Vietnam

Tuberculosis (TB) case notification rates in Vietnam have stabilized since 2000, but in 2007 were increasing among young adults. The emerging HIV epidemic only partly explains this increase. Other factors are probably involved. We aimed to assess whether rural-to-urban migration is such a factor. We conducted a case-control study at district TB units (DTUs) in Da Nang province, Vietnam, recruiting equal numbers (170) of TB patients aged 15-35 years, TB suspects of the same age in whom TB was excluded, and TB patients of 35 years and older. Risk factors for TB were assessed through interviews using pre-structured questionnaires. Among persons seeking care at DTUs, migration was not a significant risk factor for TB. Young male migrants had a lower risk of TB than other young adults (odds ratio (OR) 0.4; 95% confidence interval (95%CI) 0.03-0.64). Instead, TB was associated with male sex and a higher level of education. Compared to older TB patients, younger TB patients were more likely to be female, have a higher education level and a job involving indoor contacts with other people. Migration does not account for the increase in TB case notification rates among young adults in Vietnam. However, migration cannot be excluded as a risk factor for TB in Vietnam, because migrants may not seek diagnosis and treatment for TB at DTUs.

Clinical characteristics and treatment outcomes of tuberculosis in the elderly: a case control study

BackgroundThe purpose of this study was to evaluate the differences in clinical characteristics and treatment outcomes between older and younger tuberculosis (TB) patients in Korea.MethodsWe retrospectively analyzed the medical records of 271 younger (20–64 years old at diagnosis) and 199 older (≥65 years) TB patients who had been newly diagnosed and treated at Chonnam National University Hospital from May 2008 to August 2010.ResultsDyspnea and comorbid medical conditions were more frequent and positive TB culture rates were higher in older TB patients. In chest computed tomography (CT) scans of pulmonary TB patients, older patients were less likely to have micronodules (<7 mm in diameter), nodules (<30 mm in diameter), masses (>30 mm in diameter), and cavities compared with younger patients, but were more likely to have consolidations. Incidence of adverse drug reactions did not differ between the two groups, except for severe gastrointestinal disorders. There were no significant differences in favorable treatment outcomes between younger and older TB patients (97% vs. 94%, respectively; p = 0.251).ConclusionsOlder TB patients had more frequent dyspnea and less frequent active TB findings on chest CT. Treatment success and adverse drug reaction rates were similar in older and younger TB patients.

Manifestations of tuberculosis in elderly versus young hospitalised patients in Amritsar, India

Published literature on the clinical characteristics of tuberculosis (TB) among elderly patients in India is scarce, as the problem of geriatric TB has not received the attention it deserves. To compare the manifestations of TB among elderly and young patients. Medical records of elderly and young TB patients were extracted and compared. Elderly patients had less frequent respiratory and constitutional symptoms, but a higher prevalence of comorbidities. The median duration of symptoms was also longer in the elderly. Both groups were similar on physical examination, except that the elderly had a higher frequency of development of jaundice following anti-tuberculosis chemotherapy. Human immunodeficiency virus positivity was only present among the younger group. Both groups had significant proportions of alcoholics and drug abusers, but lesser percentage of smokers. Total admission analysis showed a male preponderance. The presentation of TB in elderly patients differs from that of younger patients in symptomatology. A high index of suspicion is therefore required to make a timely diagnosis of TB in the elderly.

Qualitative research of mental experience in first diagnosed young tuberculosis patients

Objective To understand mental experience of first diagnosed young tuberculosis patients and provide basis for clinical nursing. Methods To make depth interviews with 12 first diagnosed tuberculosis patients through phenomenological method, to extract the theme by analyzing the data. Results First diagnosed tuberculosis patient got deny, anxiety and fear in their heart and a series of emotional changes, increased demand for access to information, greater economic pressure in the process of chemotherapy, increased demand of social support. Conclusions we should concern mental status of first diagnosed young tuberculosis patient, to provide timely medical care, information, emotion help, economic and social support to alleviate the stress response and improve treatment effect. Key words: Young adults; Tuberculosis; Mental experience; Qualitative research

Facteurs associés à l'abandon du traitement anti-tuberculeux dans la ville d'Antananarivo, Madagascar

A retrospective epidemiological study of patients' medical records (n = 442) was conducted in one of the tuberculosis (TB) treatment centers in the city of Antananarivo, to identify risk factors of treatment default. Results show that males give up treatment more than women (OR=1,81 [1,13; 3,03]). Among those living farthest away from the center, patients younger than 30 years old tend to be more irregular in the follow-up of their treatment (OR=3,43 [1,16; 10,15]). There is no statistically significant relationship between TB treatment default and the patient's age, the clinical form, the therapeutic regime or the place of residence. Managers of treatment centers should be more aware and vigilant regarding male and young TB patients presenting these characteristics and should adapt methods and means for follow-up according to these risk factors.

Tuberculosis Outbreak in Marijuana Users, Seattle, Washington, 2004

Matching Mycobacterium tuberculosis isolates were noted among 11 young tuberculosis patients socially linked through illicit drug–related activities. A large proportion of their friends, 14 (64%) of 22, had positive tuberculin skin-test results. The behavior of "hotboxing" (smoking marijuana inside a closed car with friends to repeatedly inhale exhaled smoke) fueled transmission.

Comparative analysis of tuberculosis in geriatric and younger age group: An experience from rural West Bengal, India

Introduction: Tuberculosis differs clinically and radiologically in the geriatrics compared with young. Objective: The objective of the following study is to compare the profile and treatment outcome of geriatric and young tuberculosis patients. Materials and Methods: A retrospective analysis of 58 tuberculosis patients seen from November 2010 to December 2011. Study period was October to December 2012 in tuberculosis unit of Burdwan district of West Bengal Data were analyzed using Statistical Package for the Social Sciences software (version 19.0 Inc., IBM, Chicago, IL, USA). Results: Male populations were significantly more among geriatric patients. New smear positive sputum conversion and relapse cases were found more in the geriatric age group Overall, unfavorable outcome was significantly higher in geriatric compared with younger age population (33.3% vs. 17.8%). Conclusion: Geriatric and pediatric tuberculosis patients differ in diseases characteristics and outcome.