Young Adult Population Research Articles

Body heigth prediction model from foot measurement in a Chilean population of university student athletes

In forensic research, it is important to identify human remains. Body height is an essential aspect in anthropometric characterization. This is the first study in a Chilean population and aimed to develop a height estimation model for a young adult population of athletes from foot measurements. Central Chilean subjects were included (n=139). Height (H), Foot Length (FL), Foot Breadth (FB), and Heel Foot Breadth (HFB) were measured. For both sex and feet, FL was the most correlated with H (Females r > .8, p < .001; Males r > .7, p < .001). When only FL is used in the equation, similar values are obtained as when using FL + FB + HFB in females (R2 > 65%) and males (R2 > 51%). It was possible to appreciate that the mean of the data obtained from the equations is equal to the mean of the actual data. However, the minimum values tend to be overestimated, and the maximum values tend to be underestimated. It was possible to develop a mathematical model that allows predicting height from the anthropometric measurements of the feet of young adult athletes from the Metropolitan Region of Chile. Furthermore, it was shown that foot length was the measurement most correlated with height and can be used independently in the equations. This study provides valuable information in the forensic medical field, specifically in the identification of bodies in which it is impossible to determine the height directly because they are dismembered or incomplete.

Variation in physical fitness and the impact of COVID-19 in young Colombian adults: An 11-year observational retrospective study

Introduction. Low levels of physical activity (PA) have become one of society's major problems. Physical fitness is a predictor of health. Objective. The present study investigates temporary changes in lower limb power, running speed, flexibility and cardiorespiratory fitness before and after COVID-19. Material & Method. Cross-sectional data were collected from 2.942 young people (17-21 years old) of both sexes between 2011 and 2022. Performance was analyzed in relation to the explosive strength of the lower limbs based on standing long jump (SLJ), flexibility (sit-and-reach), cardiorespiratory resistance (20 m Shuttle Run Test) and speed (SP-30 m). Results.The results indicate significant (p<0.001) strong and moderate (ES = 0.45 to 1.45) decreases in the shuttle run in most periods for young people of both sexes, although the decline in women’s performance was twice that of men. The SLJ also showed a significant (p<0.001) weak and moderate (ES = 0.07-1.86) decrease in most periods, with a stronger decline in men. The sit-and-reach test did not demonstrate significant differences by either sex or period. In the SP-30 m, significant (p<0.001) weak (ES = 0.12) decreases were observed in the race time for men only between 2011-2022, while there were significant (p<0.001) strong (ES = 1.8-2.0) increases for women in some periods. Conclusions. The silent pandemic of physical inactivity and sedentary behaviors has had a greater effect than COVID-19 on levels of physical inactivity and sedentary behavior. The results of this study indicate a gradual and sustained reduction in the physical fitness of young adults throughout the past decade, which was greater than that caused by confinement due to the COVID-19 pandemic. This indicates that the level of physical fitness is so low that confinement did not generate significant effects on the reduction in physical fitness in the young adult population. In other words, the silent pandemic of physical inactivity and sedentary behaviors has had a greater effect than COVID-19 on levels of physical inactivity and sedentary behaviors. Keywords: Temporal trends, COVID-19, Physical fitness, Maximal oxygen peak, Stretching.

Mapping four decades of housing inequality research: Trends, insights, knowledge gaps, and research directions

Housing inequality is a pressing issue that affects the lives of millions of people worldwide. This study aims to determine trends, generate insights, and identify knowledge gaps in housing inequality research by systematically mapping and analysing the academic literature. As for the systematic literature review method, the PRISMA approach is employed to review literature published during the last four decades. The review is enriched with bibliometric analytics—e.g., research trends; influential publications, co-occurrence network of terms, geographical distribution—and content analysis techniques to provide future research directions. The analysis revealed four main research themes, comprising housing discrimination, housing market and urbanisation, the relationship of housing inequality with health and education, and housing inequalities among the young adult population. The majority of these studies centred their research on China. The findings in the following areas consolidate the understanding of housing inequality: (a) Housing inequality as a product of housing market dynamics; (b) Housing inequality as a condition affecting different segments of the population disparately; (c) Housing inequality as a socio-cultural concept; (d) Housing inequality as an outcome of public policy. This study advocates for multifaceted policy interventions, and the findings, which contribute to achieving relevant Sustainable Development Goals (SDGs), provide insights for urban and housing policymakers and urban planners in addressing housing inequality problems.

Obstructive sleep apnea syndrome and driving: correlation and consequences

Traffic accidents and homicides represent the majority of cases of hospitalization and death in the country in the young adult population. According to the latest data from DATASUS, from 2015, the number of deaths due to traffic accidents was 38,651 people. With these changes in sleep at night, Obstructive Sleep Apnea Syndrome is often associated with excessive daytime sleepiness, continually linked to traffic accidents, putting the lives of the driver, passengers and other participants in the traffic at risk. Traffic. In view of this, the objective of this work was to carry out a survey of the literature on studies related to sleep and Obstructive Sleep Apnea Syndrome that interferes with driving. For this purpose, the research was carried out in the period between July and August 2017 through the following databases: SCIELO, PUBMED and BIREME. According to the articles selected for this literature review, it was clear how sleep disorders, especially Obstructive Sleep Apnea Syndrome (OSAS), have a strong relationship with traffic accidents, with a significant number among drivers professionals and non-professionals.

Understanding Hope from Indian Young Adults’ Perspective

Despite the long-understood importance of Hope in the lives of individuals, few studies have investigated how Hope is understood from an Indian perspective. Furthermore, the focus on understanding the interpretations and experiences of Hope in the young adult population has been low. The current paper explores the phenomenon of Hope from Indian young adults’ perspective. The sample consisted of 10 participants, who were in the age range of 21 to 22 years and were pursuing their undergraduate or postgraduate studies. The study utilized in-depth interviews to understand the experiences and perspectives of Hope in the participants. Data were analyzed through Interpretative Phenomenological Analysis (IPA) which brought forward several themes which focused on the experiences and understanding of Hope, delineating the main features of Hope, its situations, and its cognitive, affective, and behavioral consequences. The study adds literature to the Indian understanding of Hope or conceptualizing Hope from an Indian context and provides an in-depth understanding of the construct. It gives valuable insights into how Hope can be used for stress management and promoting well-being in individuals.

Analyzing Young Adult Travelers’ Perception and Impacts of Carpooling on Traffic Sustainability

Since young adults (i.e., aged between 18 and 30) are generally more flexible and conscious of economic and environmental concerns, it is essential to assess their travel perceptions and tendency to shift towards sustainable transportation modes. Therefore, this research aims to evaluate the acceptance of carpooling (CP) in the younger population to alleviate traffic congestion, fuel demand, and pollution. This study was conducted in Islamabad, a fast-growing city in Pakistan with a high percentage of young residents, to evaluate travelers’ perceptions, mode choice decisions, and potential acceptance of CP. An online questionnaire-based survey was developed and distributed to collect a total of 656 responses from the young adult population. Various factors influencing travel perceptions, mode choice, and tendency to carpool were categorized and analyzed using confirmatory factor analysis, stepwise, and mediated multiple regression analysis. Thereafter, the tangible impacts of CP, including reduced traffic congestion, fuel consumption, and emissions resulting from the potential adoption of CP by the younger population, were quantified. The findings imply that young travelers’ mode choice mediates the relationship between travelers’ perception and the tendency to carpool. The outcomes also affirm the impact of demographic variables, including gender and education levels, on the willingness of the young adult population to shift towards carpooling. Furthermore, results predicted that adopting CP, especially by younger adults, may reduce by about 33.6% the number of private vehicles in Islamabad. The findings of this study could offer helpful insights for transport planners, commercial carpool service operators, environmentalists, and policymakers to promote carpool systems, especially among young adults.

Factors influencing high cardiovascular risk in subpopulation of young adults

Abstract Introduction The cardiovascular risk factors determine the development of early atheriosclerotic lesions, and the susceptibility to their proartheriosclerotic action is programmed by external factors and also those present during fetal development. The occurrence of atherosclerotic risk factors depends on an age. In population of children and young adults it seems reasonable to assess the classical risk factors for atherosclerosis in the connection with such additional given as family history being an indirect surrogate of genetic factors, and a low birth weight. Aim of the study was to categorize the study group into two groups - those who exhibit a low-risk and those who exhibit a high-risk of cardiovascular disease, and to determine the factors characteristic for each risk group. Materials and Methods The study was done on 512 volunteers, students in the following Faculties: Health Care Faculty: Nursing Course (178 / 34,7%), Physiotherapy Course (109 / 21,3%), Obstetrics Course (49 / 9,5%), Faculty of Medicine (176 / 34,3%). The questionnaire on cardiovascular risk factors was constructed. According to the results of its assessment the following groups were divided: the group of high risk (10% of investigated with the highest awarding of points) and the group of low risk (10% of investigated with the lowest awarding of points). Results Significant quantitative and qualitative differences were found between the low-risk and high-risk groups. Groups of the high and low risk did not differ in respect of sexes investigated and in respect of the direction of studies. One ascertained essential differences in variable qualitative and quantitative between the group of the low and high risk. Family history of diabetes, arterial hypertension, cardiovascular diseases, lipid disturbances, stroke were indeed greater in the group of high risk. The low birth weight was significantly lower in the group of high risk (p=0,02). The current and chronic stress status grading according to the punctual scale (0-10) was significantly higher in the group of high risk as compared to the low risk group (p=0,01, p=0,03, respectively). The systolic pressure was significantly higher in the high risk group in comparison to the low risk subjects (p=0,01). Conclusions High cardiovascular risk in subgroup of young adults results from high smoking status, low physical activity, diet and family history of cardiovascular disorders. The numerous cardiovascular risk factors that occur in some students are associated with low birth weight and a positive family medical history. The above observations show the influence of genetic and fetal factors on the development of atherosclerosis. Young adults with high cardiovascular risk are characterized by higher subjective stress level. Quantitative differences in high risk Medical family history

Influence and Relationship of Pain on Lumbar Biomechanics in a Young Adult Population with Non-Specific Low Back Pain.

The therapeutic actions indicated for low back pain, in addition to physiotherapy, include mobilization of the affected segment, as it is assumed that a loss of mobility may contribute to a patient's pain. The aim of this study was to investigate the influence of back pain on the degrees of spinal mobility in young adults. Eighty-six volunteers participated in the study. Fingertip-to-floor distance, Schöber's test, the fingertip-to-floor lateral flexion test, GHQ-12, the Fear-Avoidance Beliefs Questionnaire and the STarT Back Screening Tool were used. There were statistically significant differences between the two groups (pain and no pain) in degrees of spinal flexion (Schöber's test and side flexion) showing greater mobility in the group with pain. However, the group with low back pain showed less rotational mobility. The presence or absence of back pain had an impact on the individual's sporting practice and perception of pain, and they were able to carry out their sporting activities normally. Young adults with idiopathic low back pain showed some statistically significant differences in relation to the mobility of the spine in the different planes of movement (flexion and side flexion), conditioning their quality of life and sports practice.

Nutraceutical composition (yeast β-glucan, prebiotics, minerals, and silymarin) predicts improvement of sleep quality and metabolic parameters: A randomized pilot study

Background & AimsThe search for integrative and natural therapies that favor homeostasis to boost sleep and diet quality took place for young adult populations as a non-pharmacological strategy for long-term good quality of life. Thus, the present pilot study aims to investigate the effects of 90-day consumption of a nutraceutical composition on the neuro-immune-endocrine axis, providing better sleep quality and health improvement. MethodsFor this, from March 2021 to June 2021, twenty-two Brazilian young adult volunteers (women and men) with BMI between 18.5 to 34.9 kg/m2 were divided into three distinct supplementation groups: NSupple; NSupple plus_S, and NSupple plus. Briefly, the supplement compositions included yeast β-glucan, prebiotics, and minerals in different concentrations associated or not with the herbal medicine silymarin.Neither nutritional nor physical activity interventions were performed during this pilot study period. The anthropometrics measures, questionnaires answer data, and harvest blood for metabolic, inflammatory, and hormonal tests were collected at baseline time (day zero-T0) and day 90 (T90) post-supplementation. ResultsOur results highlight that the supplementation reduced body mass index (BMI), Waist-to-height ratio (WHtR), waist circumference, AST/ALT ratio, alkaline phosphatase, and HbA1c. Post-supplementation the IL-6 and IL-10 levels and the sleep, humor, and quality of life scores were suggested to improve. Sleep quality improvement seems to predict the reduction of adiposity-related body measures. ConclusionIn sum, the nutraceutical supplementation might be related to anthropometric, metabolic, and endocrine parameters after 90 days reflecting on perception of humor, sleep, and life quality enhancement. However, it is important to recognize the limitation of the data presented considering that this was a pilot study. Clinical trial registrationClinicalTrials.gov, identifier NCT04810572 registered on 20th February 2021.

Constructing the KOR152 Korean Young Adult Brain Atlas Utilizing the State-of-the-Art Method for the Age-Specific Population.

Spatial normalization is an essential process for comparative analyses that heavily depends on the standard brain template used. Brain morphological differences are observed in different populations due to genetic and environmental factors, causing mismatches in regions when the data are normalized to different population templates. Recent studies have indicated differences between Caucasian and East Asian populations as well as within East Asian populations, suggesting the necessity of population-specific brain templates. Thus, this study aimed to construct a Korean young adult age-specific brain template utilizing an advanced method of template construction to update the currently available Korean template. The KOR152 template was constructed via affine and nonlinear iterative procedures based on prior studies. We compared the morphological features of different population templates (MNI152, Indian_157, and CN200). The distance and volumetric changes before and after registering the data to these templates were calculated for registration accuracy. The KOR152 global brain features revealed a shorter overall length than the other population templates. The registration accuracy by distance and volumetric change was significantly lower than that of the other population templates, implying that the KOR152 was more accurate than other templates for the young adult Korean population. This study provided evidence for the need for a population-specific template that may be more appropriate for structural and functional studies in Korean populations.

Characterization of second primary malignancies post CAR T-cell therapy: real-world insights from the two global pharmacovigilance databases of FAERS and VigiBase

The FDA's alerts regarding the T-cell lymphoma risk post CAR-T therapy has garnered global attention, yet a comprehensive profile of second primary malignancies (SPMs) following CAR-T treatment is lacking. We extracted adverse event reports of hematological malignancies (HMs) patients with clearly definable SPMs from the FAERS and VigiBase databases (2017-2023). Disproportionality analysis using reporting odds ratio (ROR) and adjusted ROR was performed to assess associations between SPMs and CAR-T therapy. Time-to-onset analysis explored factors affecting SPM manifestation. SPMs post CAR T-cell therapy include HMs and solid tumors. T-cell lymphoma and myelodysplastic syndromes were consistently identified as positive signals across the overall and subgroup analyses. Hematological SPMs showed earlier onset with increasing annual incidence post CAR-T therapy, whereas solid tumors exhibit delayed manifestation. SPMs in CAR-T recipients had significantly earlier onset than non-recipients. Furthermore, age-specific characteristics reveal earlier SPM manifestations in pediatric, adolescent, and young adult populations compared to older populations post CAR-T therapy. The current SPM profile highlights the necessity of long-term safety monitoring for all CAR-T recipients given the observed yearly increase of SPMs. Customizing long-term SPM screening across different age groups may enhance early detection and intervention strategies, ultimately improving patient outcomes in the follow-up of CAR-T recipients. This work was supported by grants from the Natural Science Foundation of Guangdong Province (2018A030313846 and 2021A1515012593), the Science and Technology Planning Project of Guangdong Province (2019A030317020), the National Natural Science Foundation of China (81802257, 81871859, 81772457, 82172750, 82172811, and 82260546), the Guangdong Basic and Applied Basic Research Foundation (Guangdong-Guangzhou Joint Funds) (2022A1515111212), and the Science and Technology Program of Guangzhou (2023A04J1257).

STEM-05. CREATING PATIENT-DERIVED TUMOROIDS TO INVESTIGATE RADIORESISTANCE IN PEDIATRIC BRAIN TUMORS

Abstract BACKGROUND Brain cancers are the most frequently diagnosed tumor types in pediatric and young adult populations. Unfortunately, they often carry a poor prognosis and face common challenges such as treatment resistances due to intra- and intertumoral heterogeneity. To fully understand the intrinsic and extrinsic mechanisms which might hinder proper care, there is an emerging need to develop precise models of brain tumors to understand resistances and to predict therapeutic responses. While tumor-derived primary cell lines are relatively easy to produce, fully replicate the complexity of tumors as they grow without interactions with and from the microenvironment. Therefore, the advent of organoid cultures represents a significant advancement in modelling development. Derived from this technology, tumoroids offer a promising solution for modeling 3D tumors and their complex microenvironment. METHODS We develop tumoroids from fresh biopsies and patient-derived tumor xenografts. These models were rigorously validated against to initial tumor using confocal microscopy, methylome analyses, metabolomics and single-cell RNAseq. To assess the intrinsic hypoxic environment and its spatial heterogeneity, characteristic of aggressive cancers, we employed fluorescent oxygen-sensitive dye loaded polymeric nanorods. RESULTS We successfully generated tumoroids using PDX of ependymomas (BT39) and it paired relapse (BT42), two H3.3 mutated high-grade gliomas (BT35 and BT69), one ganglioglioma (BT63) and directly from fresh biopsies of DIPG sample (BT140). Several passages were obtained after primary derivation, and cryopreservation demonstrating the stability of the models over time. Tumoroids displayed similar protein and omics markers as their parental tumors and harbored specific stem cell and neural progenitor markers. The methylation patterns were entirely preserved comparing 3D models and their parental tumors, and other multiomics and metabolic approaches confirmed the accurate reconstitution of tumor complexity. The study of oxygen-sensitive nanorods highlighted the heterogeneous oxygen gradient within tumoroids. CONCLUSIONS All these initial characterized tumoroids helped us to develop radioresistant paired models.

Affective disorders and self-injurious behavior in children and young adults with carbohydrate metabolism disorders

Introduction: Affective disorders and carbohydrate metabolism disorders are problems of increasing importance in the population of children, teenagers and young adults. Much evidence indicates that these problems may co-occur with increased frequency and have much more serious consequences than on their own. Material and methods: Inclusion criteria were established for the review of studies and comprised participants under 25 years of age diagnosed with carbohydrate metabolism disorders, psychometric measurements of symptoms of affective disorders and self-aggressive tendencies. Review of the MEDLINE database was conducted. Discussion: The results of 10 out of 12 studies included in the review indicated significantly increased risk of depression and suicidal tendencies in patients with diabetes. In the described publications, the frequency of affective disorders in a specific population ranged from 1.2% to 47.6% and up to 60.4% for unspecified affective disorder, sub-threshold and fully symptomatic, and the HR ranged from 1.33 to 2.0 for fully symptomatic affective disorders and up to 6.49 for unspecified affective disorder, sub-threshold and fully symptomatic. Descriptions of the incidence of self-injurious behavior and suicidal tendencies estimate them in the range from 0.8% to 35.7%, and in the studies comparing to a control group, the risk for a suicide attempt was between HR: 1.7 and 3.25. Conclusions: The occurrence of affective disorders in children and young adults is significantly more frequent in patients with diabetes compared to patients without carbohydrate metabolism disorders. Keywords: affective disorder, depression, suicide, diabetes mellitus, children

Sex and gender differences in adverse events following influenza and COVID-19 vaccination

IntroductionActive and passive surveillance studies have found that a greater proportion of females report adverse events (AE) following receipt of either the COVID-19 or seasonal influenza vaccine compared to males. In a predominately young adult female population of healthcare workers, we sought to determine the intersection of biological sex and sociocultural gender differences in prospective active reporting of vaccine outcomes, which remains poorly characterized.MethodsThis cohort study enrolled Johns Hopkins Health System healthcare workers (HCWs) who were recruited from the mandatory annual fall 2019–2022 influenza vaccine and the fall 2022 COVID-19 bivalent vaccine campaigns. Vaccine recipients were enrolled the day of vaccination and AE surveys were administered two days post-vaccination for bivalent COVID-19 and influenza vaccine recipients. Data were collected regarding the presence of a series of solicited local and systemic AEs. Open-ended answers about participants’ experiences with AEs also were collected for the COVID-19 vaccine recipients.ResultsFemales were more likely to report local AEs after either influenza (OR = 2.28, p = 0.001) or COVID-19 (OR = 2.57, p = 0.008) vaccination compared to males, regardless of age or race. Males and females had comparable probabilities of reporting systemic AEs after either influenza (OR = 1.18, p = 0.552) or COVID-19 (OR = 0.96, p = 0.907) vaccination. Hormonal birth control use did not impact the rates of reported AEs following influenza vaccination among reproductive-aged female HCWs. Women reported more interruptions in their daily routine following COVID-19 vaccination than men and were more likely to seek out self-treatment. More women than men scheduled their COVID-19 vaccination before their days off in anticipation of AEs.ConclusionsOur findings highlight the need for sex- and gender-inclusive policies to inform more effective mandatory occupational health vaccination strategies. Further research is needed to evaluate the potential disruption of AEs on occupational responsibilities following mandated vaccination for healthcare workers, a predominately female population, and to more fully characterize the post-vaccination behavioral differences between men and women.

The effect of transcranial electrical stimulation on the relief of mental fatigue.

The presence of mental fatigue seriously affects daily life and working conditions. Non-invasive transcranial electrical stimulation has become an increasingly popular tool for relieving mental fatigue. We investigated whether transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) could be used to alleviate the state of mental fatigue in a population of healthy young adults and compared their effects. We recruited 10 participants for a blank control, repeated measures study. Each participant received 15 min of anodal tDCS, α-tACS, and blank stimulation. Participants were required to fill in the scale, perform the test task and collect ECG signals in the baseline, fatigue and post-stimulus states. We then assessed participants' subjective fatigue scale scores, test task accuracy and HRV characteristics of ECG signals separately. We found that both anodal tDCS and α-tACS significantly (P < 0.05) reduced subjective fatigue and improved accuracy on the test task compared to the blank group, and the extent of change was greater with tACS. For the HRV features extracted from ECG signals. After tACS intervention, SDNN (t = -3.241, P = 0.002), LF (t = -3.511, P = 0.001), LFn (t = -3.122, P = 0.002), LFn/HFn (-2.928, P = 0.005), TP (t = -2.706, P = 0.008), VLF (t = -3.002, P = 0.004), SD2 (t = -3.594, P = 0.001) and VLI (t = -3.564, P = 0.001) showed a significant increasing trend, and HFn (t = 3.122, P = 0.002), SD1/SD2 (t = 3.158, P = 0.002) and CCM_1 (t = 3.106, P = 0.003) showed a significant decreasing trend. After tDCS intervention, only one feature, TINN, showed a significant upward trend (P < 0.05). The other features showed non-significant changes but roughly the same trend as the tACS group. Both tDCS and α-tACS can be effective in relieving mental fatigue, and α-tACS is more effective than tDCS. This study provides theoretical support for tDCS with α-tACS having a alleviating effect on mental fatigue and the use of ECG as a valid objective assessment tool.

Overweight and Obesity Is Associated with Higher Risk of Perceived Stress and Poor Sleep Quality in Young Adults.

Background and Objectives: Overweight and obesity are growing public health challenges, particularly concerning young adults. University life presents a unique set of stressors that may influence weight management alongside sleep quality. In this cross-sectional study, we aimed to investigate the association between overweight or obesity, stress, and sleep quality in a large sample of Greek university students. Materials and Methods: The study recruited 2116 active students from across various Greek universities. Participants completed questionnaires on sociodemographics, academic performance, and physical activity levels using the International Physical Activity Questionnaire (IPAQ). Stress and sleep quality were assessed using the Perceived Stress Scale (PSS) and the Pittsburgh Sleep Quality Index (PSQI), respectively. Body weight and height were directly measured to calculate Body Mass Index (BMI). Results: Our analysis of 2116 Greek university students revealed significant associations between various factors and overweight/obesity. Compared to their rural counterparts, young adults in urban areas had an 88% higher prevalence of overweight/obesity (p = 0.0056). Regular smokers were twice as likely to be overweight or obese (p = 0.0012). Notably, those with low physical activity levels displayed a more than two-fold increased risk (p = 0.0008) compared to those with moderate or high activity levels. Similarly, students with moderate or high perceived stress levels had a more than two-fold prevalence of overweight/obesity compared to those with low stress (p = 0.0005). Inadequate sleep quality was also associated with an 86% higher risk of overweight/obesity (p = 0.0007). Interestingly, good academic performance showed a 57% greater prevalence of overweight/obesity compared to very good/excellent performance (p = 0.0103). Conclusions: Our findings reveal that perceived stress and poor sleep quality are significant risk factors for overweight and obesity in this young adult population.

Self-Reported Nonceliac Gluten Sensitivity in Italian Young Adults: A Cross-Sectional Study. A Dietary Fad?

In different countries, the exact prevalence of people that refer symptoms after gluten ingestion is increasing and the unavailability of reliable laboratory tests to diagnose the condition known as nonceliac gluten sensitivity (NCGS) has opened the door to the spread of survey-based studies to hypothesize a prevalence of this condition with highly discordant results. We aim to describe the attitude toward gluten consumption in a large population of young adults in Italy. A questionnaire-based cross-sectional study was conducted in 13 Italian cities to investigate the dietary attitudes of more than 9,400 people distributed throughout the country about gluten consumption. Only those referring to gluten-related symptoms with a frequency equal to "always" or "most of the time" were considered self-reported NCGS (SR-NCGS) patients. Five thousand two hundred thirty-four of 9,432 eligible participants (55.5%) fully completed the questionnaire. Excluding those with previous gastrointestinal diagnoses of celiac disease and wheat allergy, we have finally analyzed 4,987 questionnaires. Four hundred eighty-seven participants indicated gluten-related symptoms always or most of the time (SR-NCGS subjects), while 121 already had a medical diagnosis of NCGS. The minimum prevalence figure of SR-NCGS is 6.4% (95% confidence interval 6.0-6.9), with a higher prevalence in women (79.9%). The most frequent gluten-related symptoms were bloating, abdominal pain, and tiredness. The high prevalence of people reporting symptoms after gluten ingestion requires that the diagnosis of NCGS should be ascertained with a double-blind controlled study to limit the number of people who improperly approach a gluten-free diet.

Time to diagnosis among young patients with cancer.

Sociodemographic and clinical factors associated with diagnostic delays in pediatric, adolescent, and young adult cancers are poorly understood. Using the Optum Labs Data Warehouse's de-identified claims data for commercial health plan enrollees, we identified children (0-14years) and adolescents/young adults (AYAs) (15-39years) diagnosed with one of 10 common cancers from 2001 to 2017, who were continuously enrolled for 6months preceding diagnosis. Time to diagnosis was calculated as days between first medical encounter with possible cancer symptoms and cancer diagnosis date. Median times from first symptom to diagnosis were compared using Wilcoxon rank sum test. Multivariable unconditional logistic regression identified sociodemographic factors associated with longer time (>3months) to cancer diagnosis (from symptom onset). Of 47,296 patients, 87% presented prior to diagnosis with symptoms. Patients with central nervous system (CNS) tumors were most likely to present with symptoms (93%), whereas patients with cervical cancer were least likely (70%). Symptoms varied by malignancy. Of patients with symptoms, thyroid (105days [range: 50-154]) and cervical (104days [range: 41-151]) cancer had the longest median time to diagnosis. Females and patients at either end of the age spectrum were more likely to experience diagnosis delays of more than 3months. In a commercially insured population, time to diagnosis varies by cancer type, age, and sex. Further work is needed to understand the patient, provider, and health system-level factors contributing to time from symptom onset to diagnosis, specifically in the very young children and the young adult patient population going forward.

Myeloproliferative neoplasms in the adolescent and young adult population: A comprehensive review of the literature.

Myeloproliferative neoplasms (MPN) are characterized by a clonal proliferation of myeloid lineage cells within the bone marrow. The classical BCR-ABL negative MPNs are comprised of polycythaemia vera, essential thrombocythaemia and primary myelofibrosis. Historically, the majority of MPNs are diagnosed in adults older than 60 years of age; however, in recent years, there has been recognition of MPNs in the adolescent and young adult (AYA) population. AYAs with MPN, typically defined as between the ages of 15 and 39 years old, may comprise up to 20% of patients diagnosed with MPN. They demonstrate unique patterns of driver mutations and thrombotic events and remain at risk for progression to more aggressive disease states. Given the likely long length of time they will live with their disease, there is a significant unmet need in identifying well-tolerated and effective treatment options for these patients, particularly with the advent of disease modification. In this review, we provide a comprehensive overview of the clinical features, disease course and management of AYA patients with MPN and, in doing so, highlight key characteristics that distinguish them from their older counterparts.

Acute effects on the psychological perception of university students after participation in the "RegulACTION" workshop for the improvement of emotional health and promotion of an active lifestyle.

Prospective research in Health Sciences and Sports Sciences warns of the need to design and implement educational program at the different stages of human development, that promote emotional competences, interpersonal competences, an adequate level of healthy physical activity as well as adherence to the Mediterranean diet and a more active lifestyle on a physical and social level. The main objective of the study was to design an intervention program on intra-and interpersonal competences together with emotional education, nutritional education and healthy physical activity, called 'RegulACTION'. The preliminary study sample consisted of 11 participants aged 21-28 years (M = 5.00, SD = 8.76) (8 female and 3 males) university students. An ad hoc questionnaire was elaborated to evaluate the participant's perception of the usefulness of the 'RegulACTION' experience and a semi-structured interview of 5 questions to assess their perception, identification of their emotions, awareness of their cognitions, emotions and behaviors in the different areas of their lives. The descriptive results show that the participants are receptive to continuing training in the regulation of cognitions (thoughts) and emotions to increase their satisfaction in different areas of their lives. Regarding the qualitative results, the participants' perception, collected verbatim, is that they feel the need to apply the knowledge about personal and social emotions, as well as healthy behavior in terms of nutrition and exercise, in their daily lives. The 'RegulACTION' program is designed based on the assessment of the prevalence of mental illness in the young adult and adult population, in line with the literature review in the area of knowledge of the theory of emotions, motivational theories and on the occasion of the development of a workshop organized.