Nano technology increases the nutrient use efficiency. The experiment to test nano fertilizers on tef was conducted at the teff crop producing areas of Adet, Meray, and Meshenti areas. A total of sixteen fertilizer combinations of urea, DAP (Di Amonium phosphate) and Nano fertilizers including without fertilizer and without nano checks were tested on 2m X 1.5m plot size. The materials were planted in RCBD (Randomized Complete Block Design) with three replications. Spacing between replications and plots were 1 meter and 0.5 meter respectively. The seed and fertilizer rates were used as per recommendation rate per hectare bases. The nano fertilizer was tested as early as seed dressing and field spray during tillering stage. The performances of nano fertilizer over all locations have shown consistence results at all locations. Analysis of variance showed that there is a significant difference between the treatments for all parameters including grain yield. The highest grain yield (38 Q/ha) was recorded at the treatment combination of 2gm/ha nano seed dressing, 39g DAP and 10.8g urea. And the least grain yield (2.5 Q/ha) was recorded at treatment combination of no nano and no fertilizer treatments. Here all nano treatment combinations without DAP and urea fertilizers gave grain yield less than 7Q/ha. Which implies that Nano fertilizers cannot act solely without DAP and Urea. The least maturity date (119 dates) and the highest plant height (132.4 cm) was also recorded at a treatment combination of 2gm/ha nano seed dressing, 39g DAP and 10.8g urea. This implies that the crop at these treatments was vigor and was able to mature early.