The effect of an oxide interface on 60Co gamma radiolysis of water molecules was studied. On the basis of the molecular hydrogen yield when compared with the radiolysis of the control ampules without oxides, all the tested materials can be generally classified into three groups: I. Oxides that lower the H2 yield (MnO2, Co3O4, CuO, and Fe2O3); II. Oxides with H2 yields that are close to G values obtained in control experiments (MgO, CaO, SrO, BaO, ZnO, CdO, Cu2O, NiO, Cr2O3, Al2O3, CeO2, SiO2, TiO2, Nb2O5 and WO3); and III. Oxides that can increase the H2 yield as compared with the radiolysis of water without oxides (Ga2O3, Y2O3, La2O3, Nd2O3, Sm2O3, Eu2O3, Gd2O3, Yb2O3, Er2O3, HfO2, and ZrO2). For the third group, the H2 yield can be much greater than for the homogeneous process due to effective energy transfer at the oxide/water interface. There are several parameters, such as the oxide band-gap, water adsorption form, and energy migration distance that can collectively contribute to “enhanced” radiolys...