This paper reports the results of a study of the geochemistry of bottom sediments from the zones of mixing between the freshwater of the Ob and Yenisei rivers and the saline water of the Kara Sea by means of neutron activation analysis. Using separate datasets for the sediments of the Ob and Yenisei estuaries accumulated under identical facies conditions, some characteristic features of the distribution of a number of chemical elements (mostly lithophile group elements) were established. The differences between them were attributed to distinctive regional geological and geochemical features of the catchments of the Ob and Yenisei, which are inherited by the geochemical characteristics of terrigenous material transported to the sea. The choice of the most informative indicator elements and their grouping on the basis of the character of behavior demonstrated that bottom sediments of the Ob or Yenisei origin can be identified in the marine region studied using the geochemical characteristics of a small group of samples.