The research had as its object of study psychoactive substances, specifi cally cocaine addiction which today has a prevalence of 1.8% worldwide.In collaboration with the Onlus Incontro Community, all those subjects who undertook a residential therapeutic-rehabilitative path for a Cocaine Use Disorder, sometimes with psychiatric comorbidity, were evaluated longitudinally, in order to carry out an in-depth characterization from the point of sociodemographic, clinical and psychopathological view.The primary objective was to identify, within these clinical and psychopathological variables, the possible predictive factors of out-come in subjects affected by DUC.Furthermore, the objective was to verify how, following a three-month community journey matured from the moment of entry into the Community, the depressive symptoms, the hedonic-volitional drive, the levels of craving and the general state of health change according to the time spent in the Structure.The present was a prospective observational study that included a sample of 70 patients with a primary diagnosis of Cocaine Use Disorder, recruited consecutively at the study facility, between November 2021 and May 2022.The study envisaged, in an initial phase – within a maximum of two weeks of hospitalization – the compilation of a medical history form for the collection of socio-demographic information.Seventy patients with Cocaine Use Disorder were evaluated, of whom 49 completed the three-month followup.The sample is therefore composed of 54 male subjects (77.1%), 16 female subjects (22.9%) with an average age of 39.6 ± 10.1 years. 77.1% of the sample is unmarried, 21.4% is separated and only 1.4% is married.70% of patients live with their family of origin/spouse and 30% live alone.The level of schooling was 9.41 ± 3.70, this means that on average, the sample completed lower secondary school and attended the fi rst year of high school. 52.9% of the sample has a job, while 47.1% is unemployed.With regard to the type of occupation, 2.9% study, 21.4% perform occasional jobs and the remainder work regularly. 74.3% of the sample smoke cigarettes, with an average of 12.9 ± 9.18 per day. Furthermore, 1/3 of the sample presented legal problems.