The mechanical behavior of plain woven Carbon Fiber-Reinforced Polymer (CFRP) composites under Three-Point Bending (TPB) is investigated via experimental and numerical approaches. Multiscale models, including microscale, mesoscale and macroscale models, have been developed to characterize the TPB strength and damages. Thereinto, Representative Volume Elements (RVEs) of the microscale and mesoscale structures are established to determine the effective properties of carbon-fiber yarn and CFRP composites, respectively. Aimed at accurately and efficiently predicting the TPB behavior, an Equivalent Cross-Ply Laminate (ECPL) cell is proposed to simplify the inherent woven architecture, and the effective properties of the subcell are computed using a local homogenization approach. The macroscale model of the TPB specimen is constructed by a topology structure of ECPL cells to predict the mechanical behavior. The TPB experiments have been performed to validate the multiscale models. Both the experimental and numerical results reveal that delamination mainly appears in the top and bottom interfaces of the CFRP laminates. And matrix cracking and delamination are identified as the significant damage modes during the TPB process. Finally, the quasi-static and dynamic behaviors of plain woven composites are discussed by comparing the results of Low-Velocity Impact (LVI) and TPB simulations.