We study in detail generalized 4-dimensional fuzzy spheres with twisted extra dimensions. These spheres can be viewed as -equivariant projections of quantized coadjoint orbits of . We show that they arise as solutions in Yang–Mills matrix models, which naturally leads to higher-spin gauge theories on S4. Several types of embeddings in matrix models are found, including one with self-intersecting fuzzy extra dimensions , which is expected to entail 2 + 1 generations.