A Mw 6.3 magnitude earthquake occurred on October 6, 2008 in southern Damxung County within the N–S trending Yangyi graben, which forms the northern section of the Yadong-Gulu rift of south-central Tibet. The earthquake had a maximum intensity of IX at the village of Yangyi (also Yangying) (29°43.3′N; 90°23.6′E) and resulted in 10 deaths and 60 injured in this sparsely populated region. Field observations and focal mechanism solutions show normal fault movement occurred along the NNE-trending western boundary fault of the Yangyi graben, in agreement with the felt epicenter, pattern of the isoseismal contours, and distribution of aftershocks. The earthquake and its tectonic relations were studied in detail to provide data on the seismic hazard to the nearby city of Lhasa. The Damxung earthquake is one of the prominent events along normal and strike-slip faults that occurred widely about Tibet before and after the 2008 Mw 7.9 magnitude Wenchuan earthquake. Analysis of these recent M ⩾ 5.0 earthquake sequences demonstrate a kinematic relation between the normal, strike-slip, and reverse causative fault movements across the region. These earthquakes are found to be linked and the result of eastward extrusion of two large structural blocks of central Tibet. The reverse and oblique-slip surface faulting along the Longmenshan thrust belt at the eastern margin of the Tibetan Plateau causing the Wenchuan earthquake, was the result of eastward directed compression and crustal shortening due to the extrusion. Prior to it, east–west extensional deformation indicated by normal and strike-slip faulting events across central Tibet, had led to a build up of the compression to the east. The subsequent renewal of extensional deformational events in central Tibet appears related to some drag effect due to the crustal shortening of the Wenchuan event. Unraveling the kinematical relation between these earthquake swarms is a very helpful approach for understanding the migration of strong earthquakes across Tibet.