In rural Xuanwei County, the women have the highest rates of the lung cancer compared with other regions in China. In order to understand the relationship between indoor mass concentrations and lung cancer, samples were collected in January, March and December 2011 by using TSP-PM10-PM2.5 impactor in Xuanwei County and Liupanshui District (control), China. Mass concentrations were analyzed using the membrane filter weighing method. The results show the average 24-h mass concentrations of indoor PM10 are all lower than the value of Xingfu village (control), Guizhou province, but these are obviously higher than the national standard (150μg/m3, Indoor air pollution standards(GB/T 18883-2002)), which indicates that indoor pollution is very serious. Moreover, the indoor PM10 mass concentrations are diverse in different villages, with Jiubao to be the highest, followed by Longlin, Luoshui, Hutou, Xinjian and Caohua. All the values of indoor are higher than outdoor, which indicates that indoor PM10 in Xuanwei County mainly originates from indoor pollution. Indoor PM2.5 pollution is very severe, but outdoor fine particle is less polluted. This shows that indoor fine particle in Xuanwei County mainly originates from indoor pollution.