Event Abstract Back to Event Primary Antibody Deficient Patients and ENT Complication Alireza Ghajar1*, Asghar Aghamohammadi1, Ali Kouhi1, Marzieh Tavakol1, Mohsen Afarideh1 and Hassan Abolhassani1* 1 Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Iran The main clinical presentation of patients with primary antibody deficiency (PAD) incorporates upper respiratory tract infections comprising otitis media, sinusitis and pneumonia. This study was designed to investigate clinical and paraclinical hearing loss associated complications in important types of PAD comprehensively. Among all diagnosed patients with PAD, a cross sectional study was conducted on 55 PAD patients with diagnosis of selective IgA deficiency (SIgAD), common variable immunodeficiency (CVID), X-linked or autosomal recessive agammaglobulinemia and hyper IgM syndromes (HIgM). All patients were undergone of physical examination, tuning fork tests, pure tone audiometry, speech audiometry and auditory brain stem response. Otologic complications were detected in 54.5% of PAD patients. Conductive hearing loss was the main otologic complication amongst PID patients (73.3%) followed by SNHL which was present in 8 cases. Otitis media with effusion (21.8%), chronic otitis media (16.3%), tympanic perforation (10.9%), tympanosclerosis(5.4%) and auditory neuropathy (3.6%) were other complications in examination of PAD patients. CVID and XLA patients with prophylactic usage of antibiotic had lower rate of ENT complications (p=0.04) and Otitis media with effusion (p=0.027) respectively. Since high prevalence of hearing loss in PAD patients, a systematic otological investigation is recommended as an integral part of the management and follow-up of these patients. Keywords: Otologic Findings, Audiologic examination, Conductive hearing loss, Chronic otitis media with effusion, sensorineural hearing loss, auditory neuropathy, primary antibody deficiency Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013. Presentation Type: Abstract Topic: Adaptive Immunity Citation: Ghajar A, Aghamohammadi A, Kouhi A, Tavakol M, Afarideh M and Abolhassani H (2013). Primary Antibody Deficient Patients and ENT Complication. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00321 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 16 Mar 2013; Published Online: 22 Aug 2013. * Correspondence: Mr. Alireza Ghajar, Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran, Iran, ghajar.ar@gmail.com Dr. Hassan Abolhassani, Tehran University of Medical Science, Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran, Iran, hassan.abolhassani@ki.se Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract Supplemental Data The Authors in Frontiers Alireza Ghajar Asghar Aghamohammadi Ali Kouhi Marzieh Tavakol Mohsen Afarideh Hassan Abolhassani Google Alireza Ghajar Asghar Aghamohammadi Ali Kouhi Marzieh Tavakol Mohsen Afarideh Hassan Abolhassani Google Scholar Alireza Ghajar Asghar Aghamohammadi Ali Kouhi Marzieh Tavakol Mohsen Afarideh Hassan Abolhassani PubMed Alireza Ghajar Asghar Aghamohammadi Ali Kouhi Marzieh Tavakol Mohsen Afarideh Hassan Abolhassani Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.