Turbidity, as a key indicator of water quality linked to underwater light attenuation, is crucial for evaluating water quality. Control in high-turbidity water environments plays a critical role in navigable rivers. For this purpose, our study proposed a framework for analyzing the spatio-temporal variation of turbidity and its driving factors in a navigable and turbid river using in situ measurement data, satellite data, socioeconomic data, a power index function model, and correlation analysis. The results show that the proposed model is feasible for quantitative turbidity monitoring of the Xitiaoxi River. Its upstream turbidity is lower than downstream, with seasonal averages for spring, summer, autumn, and winter of 93.9, 111.3, 113.5, and 120.9 NTU, respectively. Furthermore, the turbidity in the middle and lower reaches of the Xitiaoxi River continuously increased before 2005 and began to decline after 2005 due to the policy of mining moratorium. This trend is especially noticeable at monitoring points along the main stream of the Xitiaoxi River, such as downstream of the Xitiaoxi River (S1), Gangkou station (S2), middle reaches of the Xitiaoxi River (S4), Hengtangcun station (S6), upper stream of the Xitiaoxi River (S7), and Huxi River (S8). Mining and shipping have significantly contributed to the turbidity of the target river. This framework offers a practical approach for assessing the environmental impacts of both natural and anthropogenic factors, thereby providing valuable insights for river management practices.