The effects of acupuncture on dementia condition of SAM-P/8 were studied in this research.The results showed that in high cross test,the frequency,time and distance which SAM-P/8 entered the dangerous area were increased obviously as compared with those of SAM-R/1(P0.01,P0.05),which indicated that SAM-P/8 were at the condition with high threshold of terror.Meanwhile,NE level in cerebral tissue of SAM-P/8 was decreased remarkably(P0.05).After the special acupuncture treatment called Xingnao Kaiqiao(醒脑开窍)method,the above conditions of SAM-P/8 were im- proved obviously,which mainly showed by the results that the frequency,time and distance which SAM-P/8 entered into the dangerous area were reducced obviously,the NE level was increased(P0.01),and the activity of SOD in cerebral tissue was strengthened distinctly(P0.05).No obvious effects on the dementia condition were observed in the group of mice treated by needling their non-acupoint locations,which indicated that acupuncture effect has remarkable specificity in the location of acupuncture;and the content of 5-HT in cerebral tissue was increased obviously,which maybe due to anxiety induced by the pain stimulation.