Recent studies have identified multiple genes associated with Alzheimer's disease (AD) that is a neurodegenerative disorder, leading to progressive memory and cognitive impairment. The current study aimed to replicate the genetic associations of 5 genes (OGG1, BIN1, SORL1, PSEN1, and NGF) with AD in Xinjiang Chinese population. In addition, we also evaluated the contribution of the promoter methylation of two genes (OGG1 and DLST) to the risk of AD. A total of 17 AD and 34 controls were recruited from Xinjiang province in China. Genotyping was done using Sanger sequencing. DNA methylation assay was performed using quantitative methylation specific PCR. Our results showed DLST methylation levels were significantly lower in AD patients (p = 0.027). Subgroup analysis by gender showed that the difference in DLST methylation was mainly contributed by females (p= 0.025). OGG1 methylation levels pointed to AD group differences with higher methylation levels in non-ɛ4 carrier than ɛ4 carrier (p = 0.027). Increasing the promoter methylation level of OGG1 did not increase the risk of AD. At the same time, the results show that APOE ɛ4 allele causes the risk of AD.