Background: Perinatal mortality includes stillbirth and the death occurring under the first one week of life. The prevalence of perinatal mortality globally is increasing, the rate is as high as 75 per 1000 birth, and studies carried out in both developed, and developing countries have identified several risk factors, including foetal, maternal, and institutional. Aim: The purpose of the study was to determine the factors associated with perinatal mortality from January 2015 to December 2019 in the University of Calabar Teaching Hospital, Calabar. In order to achieve the aim of this study, two specific objectives and two hypotheses were formulated. Methods: A non-experimental (retrospective) descriptive survey research design was adopted for the study. A total of 9571 deliveries that was recorded under the period in review was used as the population sample. A self-structured checklist was used for data collection. Data were analyzed using simple percentages, tables, bar- chart, and chi-square at p <0.05. Findings: The result shows that the prevalence rate of perinatal mortality (49.9/1000) was high in 2019. Pregnancy-induced hypertension/eclampsia 61(15.5%) was the major maternal cause of perinatal mortality. Birth asphyxia 60 (15.3%) was the major cause of perinatal foetal mortality. Uterotonic drugs usage 8(2.0%) was the major institutional factor causing perinatal mortality. Among the three causes, foetal cause was the major factor associated with perinatal mortality. A X2 value of 281.9 at p < 0.05 was obtained, showing a significant relationship between parity and perinatal mortality. Similarly, a X2 value of 63.4 at p <0.05 also showed a significant relationship between age and perinatal mortality. Conclusion and Recommendation: The study concluded that parity and age have positive significant relationships with perinatal mortality. Based on the findings, it was recommended that hospitals should increase awareness on the need for regular antenatal visits and proper routine checkups for early detection of associated factors of perinatal mortality and enlightenment should also be given to women on proper age range and number of children that can help to reduce perinatal mortality.