Rod pinch diode (RPD) is an intense X-ray point source with a millimeter spot diameter, tens of nanosecond pulsewidth, and tens of keV to MeV photon energy, resulting in extraordinary flash radiography performance. Classical RPD is featured with a high-impedance vacuum gap between the annular cathode and the central anode rod, which limits the electron current and electrical power density, therefore is not conducive to the improvement of brightness. Plasma prefilling can effectively reduce the RPD impedance, thereby increasing the electron current and realizing an impedance match of RPD with low-impedance, high-power-density drivers. In this article, an experimental study on plasma-prefilled RPD is carried out based on a fast linear transformer driver (FLTD) with relatively low charging voltage; the RPD anode and cathode are initially connected by metal wires, which are transformed into plasma shortly after the onset of discharge current. A quasi-spherical X-ray spot is obtained with <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim$</tex-math> </inline-formula> 0.45 mm diameter, <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\sim$</tex-math> </inline-formula> 30 ns pulsewidth, 0.6 rad@1 m (LiF) dose, and 55–60 keV equivalent mono-energy photon energy. The radiography performance is further characterized by a tungsten rolled-edge and slit plate. The preliminary results proved the feasibility of low-impedance RPD as a flash radiography source within the relatively low photon energy range.