X-ray Dosimetry Research Articles

Highlights and pitfalls of 20 years of application of computerised glow curve analysis to thermoluminescence research and dosimetry

The technical and dosimetric aspects of computerised glow curve analysis are described in detail including a review of the current 'state-of-the-achieved' in applications to environmental and personal dosimetry, clinical dosimetry, quality control, characterisation of new materials, continuing characterisation of 'old' materials, heavy charged particle dosimetry, mixed field n-gamma dosimetry, X-ray dosimetry and other aspects of thermoluminescence dosimetry. Fearless emphasis is placed on 'pitfalls' as well as successes.

EBT2 dosimetry of x-rays produced by the electron beam from a Plasma Focus for medical applications

The electron beam emitted from the back of Plasma Focus devices is being studied as a radiation source for intraoperative radiation therapy applications. A Plasma Focus device is being developed to this aim, to be utilized as an x-ray source. The electron beam is driven to impinge on 50 μm brass foil, where conversion x-rays are generated. Measurements with gafchromic film are performed to analyse the attenuation of the x-rays beam and to predict the dose given to the culture cell in radiobiological experiments to follow.

SU-E-I-107: Suitability of Various Radiation Detectors Used in Radiation Therapy for X-Ray Dosimetry in Computed Tomography.

Assessment of suitability for X-ray dosimetry in computed tomography of various ionization chambers, diodes and two-dimensional detector arrays primarily used in radiation therapy. An Oldelft X-ray simulation unit was used to irradiate PTW 60008, 60012 dosimetry diodes, PTW 23332, 31013, 31010, 31006 axial symmetrical ionization chambers, PTW 23343, 34001 plane parallel ionization chambers and PTW Starcheck and 2D-Array seven29 as well as a prototype Farmer chamber with a copper wall. Peak potential was varied from 50 kV up to 125 kV and beam qualities were quantified through half-value-layer measurements. Energy response was investigated free in air as well as in 2 cm depth in a solid water phantom and refers to a manufacturer calibrated PTW 60004 diode for kV-dosimetry. The thimble ionization chambers PTW 31010, 31013, the uncapsuled diode PTW 60012 and the PTW 2D-Array seven29 exhibit an energy response deviation in the investigated energy region of approximately 10% or lower thus proving good usability in X-ray dosimetry if higher spatial resolution is needed or rotational irradiations occur. It could be shown that in radiation therapy routinely used detectors are usable in a much lower energy region. The rotational symmetry is of advantage in computed tomography dosimetry and enables dose profile as well as point dose measurements in a suitable phantom for estimation of organ doses. Additional the PTW 2D-Array seven29 can give a quick overview of radiation fields in non-rotating tasks.

Spatially resolved measurement of high doses in microbeam radiation therapy using samarium doped fluorophosphate glasses

The measurement of spatially resolved high doses in microbeam radiation therapy has always been a challenging task, where a combination of high dose response and high spatial resolution (microns) is required for synchrotron radiation peaked around 50 keV. The x-ray induced Sm3+ → Sm2+ valence conversion in Sm3+ doped fluorophosphates glasses has been tested for use in x-ray dosimetry for microbeam radiation therapy. The conversion efficiency depends almost linearly on the dose of irradiation up to ∼5 Gy and saturates at doses exceeding ∼80 Gy. The conversion shows strong correlation with x-ray induced absorbance of the glass which is related to the formation of phosphorus-oxygen hole centers. When irradiated through a microslit collimator, a good spatial resolution and high “peak-to-valley” contrast have been observed by means of confocal photoluminescence microscopy.

Improved x-ray spectroscopy with room temperature CZT detectors

Compact, room temperature x-ray spectroscopy detectors are of interest in many areas including diagnostic x-ray imaging, radiation protection and dosimetry. Room temperature cadmium zinc telluride (CZT) semiconductor detectors are promising candidates for these applications. One of the major problems for CZT detectors is low-energy tailing of the energy spectrum due to hole trapping. Spectral post-correction methods to correct the tailing effect do not work well for a number of reasons; thus it is advisable to eliminate the hole trapping effect in CZT using physical methods rather than correcting an already deteriorated energy spectrum. One method is using a CZT detector with an electrode configuration which modifies the electric field in the CZT volume to decrease low-energy tailing. Another method is to irradiate the CZT surface at a tilted angle, which modifies depth of interaction to decrease low-energy tailing. Neither method alone, however, eliminates the tailing effect. In this work, we have investigated the combination of modified electric field and tilted angle irradiation in a single detector to further decrease spectral tailing. A planar CZT detector with 10 × 10 × 3 mm3 size and CZT detector with 5 × 5 × 5 mm3 size and cap-shaped electrode were used in this study. The cap-shaped electrode (referred to as CAPture technology) modifies the electric field distribution in the CZT volume and decreases the spectral tailing effect. The detectors were investigated at 90° (normal) and 30° (tilted angle) irradiation modes. Two isotope sources with 59.6 and 122 keV photon energies were used for gamma-ray spectroscopy experiments. X-ray spectroscopy was performed using collimated beams at 60, 80 and 120 kVp tube voltages, in both normal and tilted angle irradiation. Measured x-ray spectra were corrected for K x-ray escape fractions that were calculated using Monte Carlo methods. The x-ray spectra measured with tilted angle CAPture detector at 60, 80 and 120 kVp tube voltages were compared to corresponding theoretical spectra. The low-energy tailing was nearly completely eliminated from 59.6 and 122 keV isotope spectra, and 60, 80 and 120 kVp x-ray spectra, when CAPture detector was used with 30° tilted angle irradiation. It is concluded that using a CZT detector with modified electric field in tilted angle configuration resolves problem of the tailing effect in CZT detectors, opening promising possibilities in gamma-ray and x-ray spectroscopy applications.

Radiological characterization and water equivalency of genipin gel for x-ray and electron beam dosimetry

The genipin radiochromic gel offers enormous potential as a three-dimensional dosimeter in advanced radiotherapy techniques. We have used several methods (including Monte Carlo simulation), to investigate the water equivalency of genipin gel by characterizing its radiological properties, including mass and electron densities, photon interaction cross sections, mass energy absorption coefficient, effective atomic number, collisional, radiative and total mass stopping powers and electron mass scattering power. Depth doses were also calculated for clinical kilovoltage and megavoltage x-ray beams as well as megavoltage electron beams. The mass density, electron density and effective atomic number of genipin were found to differ from water by less than 2%. For energies below 150 keV, photoelectric absorption cross sections are more than 3% higher than water due to the strong dependence on atomic number. Compton scattering and pair production interaction cross sections for genipin gel differ from water by less than 1%. The mass energy absorption coefficient is approximately 3% higher than water for energies <60 keV due to the dominance of photoelectric absorption in this energy range. The electron mass stopping power and mass scattering power differ from water by approximately 0.3%. X-ray depth dose curves for genipin gel agree to within 1% with those for water. Our results demonstrate that genipin gel can be considered water equivalent for kilovoltage and megavoltage x-ray beam dosimetry. For megavoltage electron beam dosimetry, however, our results suggest that a correction factor may be needed to convert measured dose in genipin gel to that of water, since differences in some radiological properties of up to 3% compared to water are observed. Our results indicate that genipin gel exhibits greater water equivalency than polymer gels and PRESAGE formulations.

Development and evaluation of gallium nitride-based thin films for x-ray dosimetry

X-ray radiation plays an important role in medical procedures ranging from diagnostics to therapeutics. Due to the harm such ionizing radiation can cause, it has become common practice to closely monitor the dosages received by patients. To this end, precise online dosimeters have been developed with the dual objectives of monitoring radiation in the region of interest and improving therapeutic methods. In this work, we evaluate GaN thin film high electron mobility heterostructures with sub-mm2 detection areas as x-ray radiation detectors. Devices were tested using 40–300 kV Bremsstrahlung x-ray sources. We find that the photoconductive device response exhibits a large gain, is almost independent of the angle of irradiation, and is constant to within 2% of the signal throughout this medical diagnostic x-ray range, indicating that these sensors do not require recalibration for geometry or energy. Furthermore, the devices show a high sensitivity to x-ray intensity and can measure in the air kerma rate (free-in-air) range of 1 µGy s−1 to 10 mGy s−1 with a signal stability of ±1% and a linear total dose response over time. Medical conditions were simulated by measurements of device responses to irradiation through human torso phantoms. Direct x-ray imaging is demonstrated using the index finger and wrist sections of a human phantom. The results presented here indicate that GaN-based thin film devices exhibit a wide range of properties, which make them promising candidates for dosimetry applications. In addition, with potential detection volumes smaller than 10−6 cm3, they are well suited for high-resolution x-ray imaging. Moreover, with additional engineering steps, these devices can be adapted to potentially provide both in vivo biosensing and x-ray dosimetry.

Willi Dansgaard

Willi Dansgaard, a great pioneer of climate research, died on 8 January 2011 at the age of 88. He was born on 30 August 1922 and grew up in the centre of Copenhagen where his parents had an engraving shop. He finished his university degree in physics, mathematics and astronomy in 1947 with a gold medal award for a thesis on X-ray dosimetry at the Biophysics Laboratory of the University of Copenhagen. From 1947 to 1951 he was employed by the Danish Meteorological Institute where he worked in geomagnetism and meteorology. In 1947–1948 he spent a year at the geomagnetic observatory in Qeqertarsuaq, Greenland, and this led to a life long affection for that country.

Computational dosimetry of a simulated combined standard X-Rays and BNCT treatment

There has been increasing interest in combining Boron Neutron Capture Therapy (BNCT) with standard radiotherapy, either concomitantly or as a BNCT treatment of a recurrent tumor that was previously irradiated with a medical electron linear accelerator (LINAC). In this work we report the simulated dosimetry of treatments combining X-rays and BNCT.

Application of spherical micro diodes for brachytherapy dosimetry

The research presented in this paper demonstrates the feasibility and the advantages of using spherical micro diodes for radiation dosimetry. The spherical symmetry of the diode response is demonstrated, compared to that of planar diodes. The application of the spherical diode described here is for radiotherapy dosimetry, particularly brachytherapy. Measurements were done in PMMA phantoms. The advantage of the spherical diode is that it can be used for radiation measurement in a 4π geometry, it was demonstrated by measurements in both axial and azimuthal planes. The diodes were found to respond equally to radiation coming from all directions, directly from the source or due to scattered radiation within the medium. In the present work 1.8 mm diameter silicone diodes were used. The small size of these spherical diodes provides local dose measurement and can be used for in situ dosimetry while treatment takes place. Treatment planning correction can be made accordingly. Commercially available seeds of the isotopes I 125 and Pd 103 were used as radiation sources. The spherical diodes response was compared with that of planar diodes XRB generally used for UV and X-ray dosimetry, and with TLD measurements. We have also compared the measured results with Monte Carlo simulation, applying the MCNP code and with calculations shown in the TG-43 report.

ガラスバッジを用いた単純Ｘ線撮影における患者被ばく線量の測定

Radiography is used in medical practices based on the principles of justification and optimization. Patients' exposure doses should be kept as low as still allows for image quality that does not disturb the diagnostic processes. To optimize diagnostic radiological procedures, the international commission on radiological protection (ICRP) advocated the establishment of diagnosis reference levels (DRLs) in the new basic recommendation (Publication 103) in 2007 by stating that "The DRL should be expressed as a readily measurable patient-dose-related quantity for the specified procedure." In this context, a simple and standardized dosimetric method is needed to verify the adaptability of a radiation dose to the DRLs. As a measuring instrument that has good availability, high accuracy, and easy operability, we adopted the glass badge system, which has been used for individual exposure dose management. We evaluated the accuracy of the system as a tool of simplified dosimetry of diagnostic X-rays by comparing it to the standard dosimetry of an ionization chamber. In an energy range of 50 to 140 kV for X-ray exposure, the glass badge showed values within 7% of or closer to those measured by the standard ionization chamber. Moreover, the glass badge measurement was independent of the rectification modes of the X-ray tubes. In conclusion, glass badge measurement is feasible for verifying diagnostic X-ray doses in relation to DRLs and can be widely used in hospitals and clinics.

SU-GG-I-64: MicroCT-Based Methods of Assessing Imaging Dose to Active Marrow and Endosteum in CT, Fluoroscopy, and Nuclear Medicine

Purpose: To present newly developed microCT-based methods for assessing radiation dose to radiosensitive tissues of the skeleton within computational patient phantoms for CT, fluoroscopy, and nuclear medicine imaging. Methods and Materials: In this study, 13 skeletal sites were harvested from a 40-year male and a 45-year female cadaver from which 32 samples of trabecular spongiosa were cored from each and imaged under microCT. These images were thresholded and coupled to voxelized models of skeletal sites taken from the UF adult hybrid phantoms. EGSnrc-based Paired Image Radiation Transport was then performed for a series of monogenetic electrons localized in various spongiosa and cortical source tissues. The resultant electron absorbed fractions were used to assess (1) radionuclide S values for nuclear medicine dosimetry, and (2) bone-specific fluence-to-dose response functions for CT and fluoroscopic x-ray dosimetry. Results: Radionuclide S values presented in this study uniquely account for the trabecular microstructure of adult bone, account for the finite size and shape of trabecular spongiosa, and allow for electron cross-fire from particle emissions within the cortical regions of mineral bone. For assessment of bone marrow and endosteum dose during CT imaging and fluoroscopic procedures, a detailed library of photon fluence-to-dose response functions is presented for assessing both regional and skeletal average dose to active marrow and endosteum. Conclusions: Calculations of secondary electron transport in the microstructure of trabecular spongiosa of the adult skeleton reveal an enhancement of dose due to secondary electron disequilibrium for x-rays entering the skeleton at energies below 200 keV. Percent excess dose to active marrow over that predicted under the kerma approximation range from 1–5% in bones such as the pelvis to a high of 25% in the cranium. Percent excess dose to the skeletal endosteum can approach 100% in some bone sites over that predicted by the kerma approximation.

An investigation of backscatter factors for kilovoltage x-rays: a comparison between Monte Carlo simulations and Gafchromic EBT film measurements

Backscatter factors are important parameters in the determination of dose for kilovoltage x-ray beams. However, backscatter factors are difficult to measure experimentally, and tabulated values are based largely on Monte Carlo calculations. In this study we have determined new backscatter factors by both experimental and Monte Carlo methods, and compared them with existing backscatter factors published in the AAPM TG-61 protocol. The purpose of this study is twofold: (1) to evaluate the overall effectiveness of using Gafchromic EBT film for backscatter factor measurements and (2) to determine whether existing Monte Carlo-calculated backscatter factors need to be updated. We measured backscatter factors using Gafchromic EBT film for three field sizes (2, 4 and 6 cm diameter cones) and three kilovoltage beam qualities, including 280 kVp for which similar measurements have not previously been reported. We also present new Monte Carlo-calculated backscatter factors obtained using the EGSnrc/BEAMnrc code system to simulate the Pantak kilovoltage x-ray unit used in our measurements. The results were compared with backscatter factors tabulated in the AAPM TG-61 protocol for kilovoltage x-ray dosimetry. The largest difference between our measured and calculated backscatter factors and the AAPM TG-61 values was found to be 2.5%. This agreement is remarkably good, considering that the AAPM TG-61 values consist of a combination of experimental and Monte Carlo calculations obtained over 20 years ago using different measurement techniques, as well as older Monte Carlo code and cross-section data. Furthermore, our Monte Carlo-calculated backscatter factors agree within 1% with the AAPM TG-61 values for all beam qualities and field sizes. Our Gafchromic film measurements had slightly larger differences with the AAPM TG-61 backscatter factors, up to approximately 2% for the 6 cm diameter cone at a beam quality of 50 kVp. The largest difference in backscatter factors, of 2.5%, was found between Monte Carlo-calculated and Gafchromic film-measured data for the 100 kVp x-ray beam with the 4 cm diameter cone. The differences in backscatter factors between the three data sets (measurements, calculations and published values) are all within the uncertainties from our Gafchromic film measurements and Monte Carlo calculations. Our results demonstrate the suitability of using Gafchromic EBT film to measure equipment-specific backscatter factors for kilovoltage x-ray beams over the entire energy range and also confirm that backscatter factors published in kilovoltage dosimetry protocols still remain valid.

Investigation of the suitability of commercially available CVD diamond for megavoltage X-ray dosimetry

Sandwich-type X-ray detectors were fabricated on commercially available chemical vapour deposition diamond sourced from three manufacturers: Diamond Materials GmbH, Diamonex, and Element Six. These devices were investigated using Raman spectroscopy and 6 MV photons from a clinical linear accelerator. Parameters such as the level of the dark (leakage) current and photocurrent, necessary priming dose, linearity of photocurrent with dose rate, and device sensitivity were considered. Device characteristics vary considerably. Devices fabricated using Diamonex material required high priming doses, and displayed high dark currents, low photocurrents (and hence low X-ray sensitivity), and non-linear dose rate responses. In contrast, devices fabricated from Diamond Materials and Element Six material required lower priming doses, and displayed ‘zero’ dark currents (beyond the detection limit), higher photocurrents, and linear dose rate responses. In addition, the Element Six devices exhibited less variation in response when irradiated at different angles of incidence.

Low Energy Dosimetry With Photon Counting Pixel Detectors Such as Medipix

Hybrid semiconductor photon counting pixel detectors like the Medipix detector have several advantages for an use in X-ray dosimetry. The noiseless photon counting principle allows to monitor low photon energies down to 3.5 keV. Due to the small pixel size (55 mum in case of Medipix2) dosimetry at very high dose rates is possible still processing each photon individually. The large amount of pixels in combination with the possible thickness of the sensor layer enables dosimetry at very low dose rates. A method has been developed to determine personal dose equivalents from the number of counts in energy deposition intervals measured with a semiconductor photon counting pixel detector, despite the strong influence of charge sharing effects among pixels. We tested the method experimentally by reconstructing the air kerma free in air for different qualities of X-radiation in the energy range below 150 keV with an accuracy better than 4%. We show that the response of a dosimeter based on a hybrid photon counting pixel detector can fulfill the IEC type testing requirements. The statistical precision is high due to the thickness and the large area of the sensor layer. We estimate that a dosimeter based on the Medipix detector will be able to cope with dose rates of more than approximately 57 Sv/h for mathdot Hp (0.07) or 19 Sv/h for mathdot Hp(10) . We outline the advantages and perspectives of using this kind of detector in a dosimeter in comparison to standard active personal dosimeters.

Graded-gap Al xGa 1−xAs high-energy X-ray radiation dosimeter

The detectors for high-energy X-ray dosimetry based on graded-gap Al x Ga 1− x As structures were developed. Two types of graded-gap Al x Ga 1− x As structures characterized by different operating mechanisms (the first type, an internal optical response, and the second one, a charge collection by an internal graded-gap field) were investigated as high-energy X-ray radiation detectors. The linear response on absorbed dose and dose rate for both 6 and 15 MV photon beams was obtained. The angular dependence of the detector response was negligible for a wide range (±90°) of incidence angle of radiation beam. Good agreement of relative depth dose distribution measured by the first type of detector and ionization chamber in PMMA phantom is obtained in the vicinity of the absorbed dose maximum. The radiation field profile measurements show a better spatial resolution of the graded-gap Al x Ga 1− x As detector in comparison with the spatial resolution of the small-volume ionization chamber. The experimental results of this study demonstrate suitability of the graded-gap Al x Ga 1− x As detector for relative dosimetry of high-energy X-ray beams, especially for a high spatial resolution measurement.

X-ray-induced conductivity in gallium sesqui-selenide

The X-ray-induced dc conductivity of gallium sesqui-selenide (Ga2Se3) crystals characterized by anomalously high radiation resistance was studied as a function of the intensity of incident radiation. The obtained results show that Ga2Se3 crystals can be used as working elements of detectors for X-ray dosimetry in the range of radiation intensities studied.

Kilovoltage x-ray dosimetry—an experimental comparison between different dosimetry protocols

Kilovoltage dosimetry protocols by the IAEA (TRS-277 and TRS-398), DIN (6809), IPEMB (with addendum), AAPM (TG-61) and NCS (report 10) were compared experimentally in four clinical beams. The beams had acceleration potentials of 30, 80, 120 and 200 kV, with half-value layers ranging from 0.6 mm Al to 1 mm Cu. Dosimetric measurements were performed and data were collected under reference conditions as stipulated within each separate protocol under investigation. The Monte Carlo method was used to derive backscatter factors for the actual x-ray machine. In general, the agreement of the dosimetric data at the surface of a full-scatter water phantom obtained using the guidelines of the various protocols was fairly good, i.e. within 1–2%. However, the in-air calibration method using the IPEMB and AAPM TG-61 protocols yielded an absorbed dose about 7% lower than the IAEA TRS-398 protocol in the 120 kV beam. By replacing the backscatter factors given in the protocols with Monte Carlo calculated backscatter factors, the convergence between the protocols improved (within 4%). The internal consistency obtained for protocols supporting more than one geometry for dosimetry under reference conditions was better than 0.2% for the DIN protocol (120 kV beam), 2–3% for the AAPM TG-61 (120 and 200 kV beams) and about 2% for the IPEMB protocol (200 kV beam). The present study shows that the current-supported dosimetry protocols in the kilovoltage range were in fairly good agreement, and there were only a few exceptions of clinical significance.

Anniversary Paper: Fifty years of AAPM involvement in radiation dosimetry

This article reviews the involvement of the AAPM in various aspects of radiation dosimetry over its 50 year history, emphasizing the especially important role that external beam dosimetry played in the early formation of the organization. Topics covered include the AAPM's involvement with external beam and x-ray dosimetry protocols, brachytherapy dosimetry, primary standards laboratories, accredited dosimetry chains, and audits for machine calibrations through the Radiological Physics Center.

Peripheral dose in ocular treatments with CyberKnife and Gamma Knife radiosurgery compared to proton radiotherapy

Peripheral radiation can have deleterious effects on normal tissues throughout the body, including secondary cancer induction and cataractogenesis. The aim of this study is to evaluate the peripheral dose received by various regions of the body after ocular treatment delivered with the Model C Gamma Knife, proton radiotherapy with a dedicated ocular beam employing no passive-scattering system, or a CyberKnife unit before and after supplemental shielding was introduced. TLDs were used for stray gamma and x-ray dosimetry, whereas CR-39 dosimeters were used to measure neutron contamination in the proton experiments. Doses to the contralateral eye, neck, thorax and abdomen were measured on our anthropomorphic phantom for a 56 Gy treatment to a 588 mm3 posterior ocular lesion. Gamma Knife (without collimator blocking) delivered the highest dose in the contralateral eye, with 402–2380 mSv, as compared with 118–234 mSv for CyberKnife pre-shielding, 46–255 mSv for CyberKnife post-shielding and 9–12 mSv for proton radiotherapy. Gamma Knife and post-shielding CyberKnife delivered comparable doses proximal to the treatment site, with 190 versus 196 mSv at the thyroid, whereas protons doses at these locations were less than 10 mSv. Gamma Knife doses decreased dramatically with distance from the treatment site, delivering only 13 mSv at the lower pelvis, comparable to the proton result of 4 to 7 mSv in this region. In contrast, CyberKnife delivered between 117 and 132 mSv to the lower pelvis. In conclusion, for ocular melanoma treatments, a proton beam employing no double scattering system delivers the lowest peripheral doses proximally to the contralateral eye and thyroid when compared to radiosurgery with the Model C Gamma Knife or CyberKnife. At distal locations in the pelvis, peripheral doses delivered with proton and Gamma Knife are of an order of magnitude smaller than those delivered with CyberKnife.