The aim of this work is the comparative characterization of the fatigue and damage behaviors of GFR-polyurethane and GFR-epoxy with application-relevant quasi-isotropic layer setup in the high cycle and very-high cycle fatigue regimes. Therefore, a high-frequency test method based on a resonant testing system (1 kHz) has been further developed and assessed with special consideration of self-heating. In intermittent test procedures, the damage state has been explored by in situ X-ray computed tomography analysis after certain numbers of cycles. It was shown that the overall damage state in the VHCF regime is reduced by a factor of three compared to the HCF regime and accompanied by delayed initiation and propagation of delamination. The latter was proven to be the main reason for a decreased inclination of the S/N-curve in the VHCF regime by 50-60%.