Steel-hollow core partially encased composite spliced frame beam (SHSFB) and middle partially encased composite brace (MPECB) demonstrate the potential to economize on steel consumption while exhibiting superior performance. To investigate the seismic performance of frames with SHSFBs and MPECBs, horizontal low-cyclic loading tests were conducted on four frame specimens, involving two two-story frames with no brace and two multi-story X-braced frames. Numerical simulations were performed using the “Open System for Earthquake Engineering Simulation” (OpenSees). The results indicate that the novel composite frames exhibit commendable seismic performance and energy dissipation capacity. The unbraced frame with SHSFBs has deformation capacity and mechanical properties comparable to bare steel frame. In contrast to the frame specimen equipped with bare steel braces featuring a 6 mm flange thickness, the specimen utilizing MPECBs with 4 mm flange thickness exhibits only a slight reduction of 3.60 % in maximum bearing capacity and 2.68 % in initial lateral stiffness. Significantly, each SHSFB and MPECB component reduces steel consumption by 16.71 % and 24.79 %, respectively, compared to bare steel components. Therefore, while ensuring adequate mechanical properties, frame structures equipped with SHSFBs and MPECBs will require less steel. Based on both experimental and simulation results, the formulas for predicting the ultimate bearing capacity and initial lateral stiffness of the novel composite frame were proposed, and the structural design for the multi-story X-braced frame was analyzed, offering valuable insights for practical engineering applications.