Abstract: Medical demands during the COVID-19 pandemic have triggered a grave shortage of medical-grade personal protective equipment (PPE), especially, N95 respirators. N95 respirators are critical for the personal protection of medical providers and others when being exposed to individuals with infections caused by the SARS- CoV-2 coronavirus. To address the shortage of PPE Kit & N95 respirators, innovative methods are needed to decontaminate coronaviruses from N95 respirators & PPE Kit, allowing them to be safely reused by healthcare workers. For this research, we use a commercial ozone disinfecting cabinet to examine the efficacy of ozone-based disinfection of a conservative surrogate virus for SARS-CoV-2/Ultra Violet radiation, Chlorination, washing with soap and heating are some methods of sterilizing. Ultra Violet light is thebest sterilizing and disinfectant agent, used for domestic as well as clinical purpose. Food packets, books, stationery, medical equipment’s, toys, electronic gadgets like mobile phones, laptops, wrist watches, etc. can be sterilized with UV radiation whereasother methods of sterilization cannot be used. UV light does not release any waste andis eco-friendly, if used in a controlled manner. UV radiation is a range of electromagnetic waves with shorter wavelength (high frequency and energy). The wavelength from 100-280 nm known as UV-C isthe best disinfectant used for purifying water, air, sterilizing vegetables and surgical equipment’s. Research has shown that UV-C wavelength can kill harmful fungi, protozoa, bacteria and viruses like SARS- CoV-2 Virus. The article describes the construction of a low-cost UV-C Sterilizer Boxwhere UV radiation is taking place in a closed environment. Safety features are also incorporated to prevent humans from UV light exposure. The germicidal property of ultraviolet-C is well known. This review will cover the most commonly described methods for sterilization of PPE Kit, namely, ultraviolet germicidal irradiation. These techniques have been tested previously and have demonstrated efficacy in reducing or inactivating viral and bacterial pathogens, although testing against SARS-CoV-2 specifically has not been done. Moreover, it must be emphasized that proper disposal after a single use is still ideal under normal circumstances. Keywords: UV, UV-C LED, Sterilize, Ultraviolet-C; decontamination; N95 respirator; peracetic acid; SARS-CoV-2, ozone