Wound Care Treatment Research Articles

Polyphenols in wound healing: unlocking prospects with clinical applications.

Wound healing is a multifaceted, complex process that factors like aging, metabolic diseases, and infections may influence. The potentiality of polyphenols, natural compounds, has shown anti-inflammatory and antimicrobial properties in promoting wound healing and their potential applications in wound management. The studies reviewed indicate that polyphenols have multiple mechanisms that promote wound healing. This involves enhancing antioxidant defenses, reducing oxidative stress, modulating inflammatory responses, improving healing times, reducing infection rates, and enhancing tissue regeneration in clinical trials and in vivo and in vitro studies. Polyphenols have been proven to be effective in managing hard-to-heal wounds, especially in diabetic and elderly populations. Polyphenols have shown significant benefits in promoting angiogenesis and stimulating collagen synthesis. Polyphenol treatment has been demonstrated to have therapeutic effects in wound healing and chronic wound management. Their ability to regulate key healing processes makes them suitable for new wound care products and treatments. Future research should enhance formulations and delivery methods to optimize polyphenols' bioavailability and therapeutic efficacy in wound management approaches.

Case Report: Delayed Diagnosis of Leprosy-Related Neuropathic Ulcer, Insights from a Case of Delay to Diagnose across Four Clinical Settings

Background Neuropathy is common in both Diabetes Mellitus (DM) and Leprosy, often resulting in neuropathic ulcers. Leprosy-related neuropathic ulcers are frequently misdiagnosed as DM-related, causing delays in appropriate care. This case report underscores the importance of timely recognition and a better understanding of Leprosy-related neuropathic ulcers to prevent misdiagnosis and improve patient outcomes. Methods The case report adopt the CARE Guidelines and was conducted at the Wound Care Specialist Clinic, Griya Afiat, Makassar, East Indonesia. Data were collected using a Minimum Data Sheet (MDS) to capture demographics, health history, and history of treatments. A head-to-toe assessment focused on the eyes, hands, and feet, with neuropathy, confirmed using the Semmes Weinstein Monofilament test, and angiopathy was assessed by palpating the dorsal pedis and posterior tibialis pulse. Wound care interventions consisted of cleansing, debridement, and dressing. Given the similarities between Leprosy-related neuropathic ulcers and DM-related neuropathic ulcers, the DMIST (depth, maceration, inflammation/infection, size, tissue type of the wound bed, type of wound edge, and tunnelling/undermining) tool was used to evaluate wound healing progress. Results Anamnesis indicated patient has no DM, with normal blood glucose; however, the patient had neuropathic wounds on her feet, asymmetrical eyebrow distribution, and rashes on her hands and calves, with neuropathy confirmed by a monofilament test—initial treatment involved Cadexomer Iodine powder to control bacterial growth and Honey-based gel to promote granulation. Over 62 days, 11 treatments were administered, with an average dressing change every 5.6 days, which improved the DMIST score from 12 to 4 by the end of observation day. Conclusions This case report highlights the significance of distinguishing leprosy-related neuropathic ulcers from those associated with DM to ensure accurate diagnosis and timely treatment. By employing comprehensive assessment tools and targeted wound care interventions, significant improvements in wound healing were achieved, emphasizing the need for greater awareness and clinical vigilance in managing Leprosy-related neuropathic ulcers.

Enhanced Wound Healing With β-Chitosan-Zinc Oxide Nanoparticles: Insights From Zebrafish Models.

Wound healing is a complex physiological process essential for the restoration of tissue integrity and function.Novel therapeutic approaches are urgently needed to enhance wound-healing outcomes. Nanotechnology, particularly zinc oxide nanoparticles, has shown promise due to its antimicrobial, anti-inflammatory, and regenerative properties.β-chitosan, derived from squid pens, possesses superior solubility and bioactivity compared toα-chitosan, making it a valuable biomaterial for biomedical applications. Through the integration ofβ-chitosan and zinc oxide nanoparticles, this study seeks to use the complementary properties of both substances to overcome present constraints in wound care treatments. β-chitosan was extracted from squid pens and characterized for its molecular weight, degree of deacetylation, and solubility properties. Further characterization of the synthesized zinc oxide nanoparticles involved Fourier transform infrared spectroscopyto analyze chemical bonding and functional groups, ultraviolet-visible spectroscopy to determine optional properties such as band gap energy, X-ray diffraction spectroscopy to confirm the crystalline phase and calculate crystallite size, and the size was confirmed with the scanning electron microscope. Each technique provided complementary information, ensuring a comprehensive understanding of the synthesized nanoparticles' properties and their potential applications. Adult zebrafish (six to eight months old) were employed as a model organism due to their genetic similarity to humans and regenerative capabilities. Zebrafishwere wounded and divided into treatment and control groups, withβ-chitosan andβ-chitosan-derived zinc nanoparticlestreatments administrated at 50 µg/ml, while control groups received 0.05% phosphate buffer saline. The treatments, conducted in triplicate, enabled a comparative analysis of wound closure activity between β-chitosan-derived zinc nanoparticles' healing effects against standard and baseline treatments. Further, gene expression analysis on Bax, BCl-2, IL-2, IL-6, and tumor necrosis factor-alpha (TNF-a) was done using reverse transcriptase polymerase chain reaction. Characterization studies confirmed the successful synthesis ofβ-chitosan-derived zinc oxide nanoparticles and a crystalline structure corresponding to zinc oxide. Treatment withβ-chitosan-derived zinc oxide nanoparticles significantly accelerated wound closure compared to controls and other treatment groups. Microscopic analysis demonstratedenhanced epithelialization, reduced inflammatory cell infiltration, increased collagen deposition, and improved tissue organization in wounds treatedwithβ-chitosan-derived zinc oxide nanoparticles. Gene expression analysis revealed downregulation of inflammation-causing genes such as BCl-2, IL-2, IL-6, and TNF-a, hence it showed wound-healing activity. The results were statistically significant (p < 0.05). β-chitosan-derived zinc oxide nanoparticles show promising potential as a novel therapeutic strategy for enhancing wound healing. The synergistic effects ofβ-chitosan and zinc oxide nanoparticles address multiple aspects of wound healing, including antimicrobial activity, inflammation modulation, and tissue regeneration. This study highlights the advantages of nanotechnology in wound care and underscores the need for further research to optimize nanoparticle formulations for clinical applications.

54009 Maximizing wound care treatment post discharge in patients affected by homelessness

54009 Maximizing wound care treatment post discharge in patients affected by homelessness

Drug use practices and wound care experiences in the age of xylazine adulteration

Exposure to xylazine has been associated with wounds distinct from typical injection-related skin and soft tissue infections. We sought to understand drug use and wound care practices, and treatment experiences of people who use drugs (PWUD) in a high-prevalence area of xylazine adulteration. In August 2023, we surveyed adult PWUD reporting at least one past-year drug use-related wound across three Massachusetts syringe service programs. Using a representative illustration, participants indicated if they had experienced a xylazine wound in the past 90 days. We compared demographic, drug use factors, wound care, and medical treatment experiences among those with and without xylazine wounds. We also conducted additional content analysis of open-ended responses. Of the 171 respondents, 87 % (n=148) had a xylazine wound in the past 90 days. There were no statistically significant demographic differences between those with and without xylazine wounds. Among those primarily injecting (n=155), subcutaneous injection was nearly ten times more likely among people with xylazine wounds. For those with xylazine wounds (n=148), many engaged in heterogeneous wound self-treatment practices, and when seeking medical care, 74 % experienced healthcare stigma and 58 % had inadequate pain and withdrawal management. People with self-identified xylazine wounds were more likely to engage in subcutaneous injection and faced several barriers seeking medical wound treatment. Programs serving people exposed to xylazine should work to support safer injection practices, including alternatives to injecting and improving access to high-quality, effective wound care. Further study is warranted to understand the causes, promoters, and prevention of xylazine-related wounds.

Utility of synthetic electrospun fiber matrix in general surgery: From head to toe

BackgroundTo highlight the role of a novel synthetic electrospun fiber matrix in the treatment of high-risk wounds across a range of etiologies. MethodsThis was a retrospective study of patients at a single institution who underwent complex wound care treatment with at least 1 application of the electrospun fiber matrix from January 2021 to December 2022. Information regarding patient demographics, wound size and etiologies, pertinent medical history, and treatment outcomes was collected. ResultsTwenty-one patients with 24 complex wounds who received synthetic electrospun fiber matrix treatment were identified. Nineteen patients (22 wounds) met the inclusion criteria for analysis. Patient mean age was 63.58 ± 15.20 (range 34–90) years. A wide range of wound etiologies was represented, including transmetatarsal amputation secondary to frostbite (n = 1), post-Mohs defect (n = 2), acute trauma (n = 3), surgical dehiscence (n = 3), infected implanted medical device (n = 2), chronic ulcers (n = 3), partial ray resection (n = 1), pilonidal cyst (n = 1), rattlesnake bite (n = 1), necrotizing soft-tissue infection (n = 1), and others (n = 2). A total of 17 of 19 (89.5%) patients were observed to meet their individual clinical goals after application of the wound matrix. Wound ages ranged from 1 to 429 days before initial synthetic electrospun fiber matrix application. ConclusionThe synthetic nature of the matrix limits the risk of inflammatory response and is well tolerated, which demonstrates initial proof of concept of synthetic electrospun fiber matrix treatment in a variety of complex wounds. The positive results observed across this mixed etiology surgical analysis should be replicated in future controlled, single-etiology studies to further confirm the utility of the electrospun fiber matrix in the surgical setting.

Wound Care Capacity of the Addiction Workforce in the Setting of Xylazine.

As xylazine increasingly adulterates the unregulated opioid supply, people who use drugs (PWUD) are more likely to experience sequalae from xylazine. Given xylazine exposure is consistently associated with development of wounds which can heal with medically directed wound care, we sought to understand the level of preparedness and ability of front-line addiction professionals who interact with PWUD to provide wound care treatment. We administered a 26-item online survey assessing participant and organizational characteristics, level of wound care training, ability to test for xylazine and treat xylazine-associated wounds, and funding and billing characteristics to a national sample of addiction professionals using a listserv of over 11,000 individuals. We had a response rate of 12.8% in which 1,280 met eligibility criteria and completed the survey, with the majority (23.7%) being nurses. While nearly all participants had cared for patients who had experienced any xylazine-associated harms, less than half (43.6%) had cared for patients with xylazine wounds and 43.4% had any training or certification in wound care, including 26.9% of physicians. Although 75.9% of participants had access to wound care supplies, just 19.5% provided wound care services onsite. Most addiction professionals, especially physicians, lack wound care training and do not provide onsite treatment for drug-associated wounds at the organizational level. There is a critical need to bridge this gap in knowledge and build capacity to provide evidence-based wound care services to PWUD in areas impacted by xylazine adulteration.

Hyaluronic Acid/Chondroitin Sulfate-Based Dynamic Thiol-Aldehyde Addition Hydrogel: An Injectable, Self-Healing, On-Demand Dissolution Wound Dressing.

Frequent removal and reapplication of wound dressings can cause mechanical disruption to the healing process and significant physical discomfort for patients. In response to this challenge, a dynamic covalent hydrogel has been developed to advance wound care strategies. This system comprises aldehyde functionalized chondroitin sulfate (CS-CHO) and thiolated hyaluronic acid (HA-SH), with the distinct ability to form in situ via thiol-aldehyde addition and dissolve on-demand via the thiol-hemithioacetal exchange reaction. Although rarely reported, the dynamic covalent reaction of thiol-aldehyde addition holds great promise for the preparation of dynamic hydrogels due to its rapid reaction kinetics and easy reversible dissociation. The thiol-aldehyde addition chemistry provides the hydrogel system with highly desirable characteristics of rapid gelation (within seconds), self-healing, and on-demand dissolution (within 30 min). The mechanical and dissolution properties of the hydrogel can be easily tuned by utilizing CS-CHO materials of different aldehyde functional group contents. The chemical structure, rheology, self-healing, swelling profile, degradation rate, and cell biocompatibility of the hydrogels are characterized. The hydrogel possesses excellent biocompatibility and proves to be significant in promoting cell proliferation in vitro when compared to a commercial hydrogel (HyStem® Cell Culture Scaffold Kit). This study introduces the simple fabrication of a new dynamic hydrogel system that can serve as an ideal platform for biomedical applications, particularly in wound care treatments as an on-demand dissolvable wound dressing.

An Alternative Approach: Decellularized Dermal Matrices For Pilonidal Sinus When Standard Care Falls Short

This case study explores the challenges and management strategies associated with a recurrent pilonidal sinus wound in a young female patient. It highlights the importance of advanced wound care interventions and novel approaches in achieving successful healing outcomes when standard care is insufficient.

EFECTIVENESS OF USING A COMBINATION OF HYDROGEL AND HYDROCELLULAR FOAM IN THE PROCESS OF AUTOLYTIC DEBRIDEMENT IN HEALING DIABETIC ULCERS

Diabetic ulcers are a chronic complications of diabetes mellitus, which can increase the prevalence of morbidity and mortality in diabetes mellitus sufferers. To prevent this incident, diabetic ulcers, which are chronic wounds, need to be given proper and correct wound care. This research aims to determine the effectiveness of using a combination of hydrogel and hydrocellular foam in the autolytic debridement process for healing diabetic ulcers. This case report involves two respondents suffering from diabetes mellitus complicated by diabetic ulcers. This wound care intervention was carried out by a certified expert nurse eight times within a period of 14 days. Then, in assessing the progress of wound healing in the two respondents, the researcher used the Wocare for Indonesian Nurses (WINNERS) Scale observation sheet. The results of the study showed that the condition of the diabetic ulcers in both respondents experienced healing, which was characterized by increased growth of granulation tissue and epithelialization at the edges of the wound; the diameter and depth of the wound decreased; the GOA in the wound decreased; the characteristics of the exudate changed; and the amount of exudate decreased. The use of a combination of hydrogel and hydrocellular foam, which has proven to be effective in assisting the autolytic debridement process and increasing the speed of wound healing, can be carried out on various types and severity of wounds without causing any side effects.

Colocating Syringe Services, COVID-19 Vaccination, And Infectious Disease Testing: Baltimore's Experience.

People who inject drugs face many challenges that contribute to poor health outcomes, including drug overdose, HIV, and hepatitis C infections. These conditions require high-quality prevention and treatment services. Syringe services programs are evidence-based harm reduction programs, and they have established track records with people who inject drugs, earning them deep trust within this population. In Baltimore, Maryland, although many syringe support services were limited during the COVID-19 pandemic, the health department's syringe services programs remained operational, allowing for the continuation of harm reduction services, including naloxone distribution. This evaluation describes a collaborative effort to colocate infectious disease testing and COVID-19 vaccination with a syringe services program. Our evaluation demonstrated that colocation of important services with trusted community partners can facilitate engagement and is essential for service uptake. Maintaining adequate and consistent funding for these services is central to program success. Colocation of other services within syringe services programs, such as medications for opioid use disorder, wound care, and infectious disease treatment, would further expand health care access for people who inject drugs.

NECROTIZING FACICIT AFTER HEMOROIDECTOMY

Necrotizing fasciitis (NF); is a progressive soft tissue infection involving the lower extremities and perianal region, extending from the skin to the fascia. Although it is frequently seen in the elderly, it can be seen in all age groups with concomitant diseases, previous surgery history, and immune system disorders. NF, which develops as a result of rapid tissue invasion, can cause serious morbidity and mortality if early diagnosis and early surgical debridement are not performed. Therefore, NF should be suspected if pain, fever, and septic markers are disproportionate to the lesion in the clinic. The most important step in the treatment of NF is early surgical debridement and initiation of appropriate antibiotics. In addition to these treatments, various wound care treatments can also be applied. We tried to explain the process from diagnosis to discharge in a patient who developed NF after hemorrhoidectomy in terms of treatment management.

Impact of Thermo-Responsive N-Acetylcysteine Hydrogel on Dermal Wound Healing and Oral Ulcer Regeneration.

This study investigates the efficacy of a thermo-responsive N-acetylcysteine (NAC) hydrogel on wound healing and oral ulcer recovery. Formulated by combining NAC with methylcellulose, the hydrogel's properties were assessed for temperature-induced gelation and cell viability using human fibroblast cells. In vivo experiments on Sprague Dawley rats compared the hydrogel's effects against saline, NAC solution, and a commercial NAC product. Results show that a 5% NAC and 1% methylcellulose solution exhibited optimal outcomes. While modest improvements in wound healing were observed, significant enhancements were noted in oral ulcer recovery, with histological analyses indicating fully regenerated mucosal tissue. The study concludes that modifying viscosity enhances NAC retention, facilitating tissue regeneration. These findings support previous research on the beneficial effects of antioxidant application on damaged tissues, suggesting the potential of NAC hydrogels in improving wound care and oral ulcer treatment.

Long-Acting Gel Formulations: Advancing Drug Delivery across Diverse Therapeutic Areas.

This multifaceted landscape of long-acting gels in diverse medical fields, aims to enhance therapeutic outcomes through localized treatment and controlled drug release. The objective involves advancements spanning cancer treatment, immunotherapy, diabetes management, neuroendocrine disorders, ophthalmic applications, contraception, HIV/AIDS treatment, chronic diseases, wound care, and antimicrobial treatments. It explores the potential of long-acting gels to offer sustained and extended drug release, targeted therapy, and innovative administration routes while addressing limitations such as scalability challenges and regulatory hurdles. Future directions focus on personalized therapies, biodegradability, combination therapies, interdisciplinary innovation, regulatory considerations, and patient-centric development. This comprehensive review highlights the pivotal role of long-acting gels in transforming therapeutic approaches and improving patient outcomes across various medical conditions.

Oxidized alginate-gelatin (ADA-GEL)/silk fibroin/Cu-Ag doped mesoporous bioactive glass nanoparticle-based hydrogels for potential wound care treatments

The present work focuses on developing 5% w/v oxidized alginate (alginate di aldehyde, ADA)-7.5% w/v gelatin (GEL) hydrogels incorporating 0.25% w/v silk fibroin (SF) and loaded with 0.3% w/v Cu-Ag doped mesoporous bioactive glass nanoparticles (Cu-Ag MBGNs). The microstructural, mechanical, and biological properties of the composite hydrogels were characterized in detail. The porous microstructure of the developed ADA-GEL based hydrogels was confirmed by scanning electron microscopy, while the presence of Cu-Ag MBGNs in the synthesized hydrogels was determined using energy dispersive x-ray spectroscopy. The incorporation of 0.3% w/v Cu-Ag MBGNs reduced the mechanical properties of the synthesized hydrogels, as investigated using micro-tensile testing. The synthesized ADA-GEL loaded with 0.25% w/v SF and 0.3% w/v Cu-Ag MBGNs showed a potent antibacterial effect against Escherichia coli and Staphylococcus aureus. Cellular studies using the NIH3T3-E1 fibroblast cell line confirmed that ADA-GEL films incorporated with 0.3% w/v Cu-Ag MBGNs exhibited promising cellular viability as compared to pure ADA-GEL (determined by WST-8 assay). The addition of SF improved the biocompatibility, degradation rate, moisturizing effects, and stretchability of the developed hydrogels, as determined in vitro. Such multimaterial hydrogels can stimulate angiogenesis and exhibit desirable antibacterial properties. Therefore further (in vivo) tests are justified to assess the hydrogels’ potential for wound dressing and skin tissue healing applications.

Evaluation of risk factors associated with hard-to-heal wound infection in a tertiary care hospital.

The incidence of hard-to-heal wound infection, especially as a result of multidrug-resistant Gram-negative organisms, has increased in recent years. The reason for the increase is multifactorial and the ability of these pathogenic isolates to form biofilms is one of the important risk factors in wound infection. This study aimed to evaluate the risk factors associated with such cases. This prospective analytical study, conducted over a period of two months, included pus or tissue samples from hospital inpatients with Gram-negative hard-to-heal wound infection. The samples were processed with conventional microbiological techniques. Patient demographic details and the presence of various risk factors were recorded. Biofilm production was detected by tissue culture plate method in the laboratory. The data were analysed using SPSS version 21 (IBM Ltd., US). The experimental cohort comprised 200 patients. Klebsiella spp. was the most common identified organism, followed by Escherichia coli and Pseudomonas spp. Carbapenem resistance was observed in 106 (53%) strains. Almost 66% of the strains showed biofilm formation. On evaluation of associated risk factors, age (p=0.043), presence of biofilms (p=0.0001), diabetes (p=0.002), hypertension (p=0.02) and medical device use (p=0.008) had significant association, whereas sex, previous surgery and prior antibiotic use had no significant impact on the chronicity of the wound. In this study, chronicity of wounds was observed to be associated with multiple risk factors, especially the biofilm-forming ability of the strain. Biofilms are difficult to eradicate and additional measures, such as physical debridement, are important for resolving chronicity. Knowledge about specific risk factors would also allow clinicians a better understanding of the healing process and drive appropriate wound care interventions. A grant was received from the Indian Council of Medical Research (ICMR) for this work (grant ID: 2017-02686). The authors have no conflicts of interest to declare.

Silver carboxylate-TiO2/polydimethyl siloxane is a safe and effective antimicrobial with significant wound care potential.

With the rise in antibiotic resistance, new methodologies are needed to combat musculoskeletal infections. Silver is an antimicrobial that can be synthesized in different forms, but its pharmacokinetics are difficult to control. This study details the antibacterial efficacy and cellular cytotoxicity of a formulation consisting of silver carboxylate (AgCar) released through a titanium dioxide/polydimethylsiloxane matrix with a predictable release profile on Pseudomonas aeruginosa, Acinetobacterium baumannii, and human-derived primary osteoblasts. Through an Institutional Animal Care and Use Committee and IRB-approved protocol, AgCar was applied to live Yucatan porcine skin and histologically analyzed for skin penetration. Graphite Furnace Atomic Absorption Spectroscopy (GFAAS) was used to measure elution of AgCar. Dose-response curves were generated through optical density to assess potency. Finally, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay was used to quantify the cellular cytotoxicity of the novel formulation. The results were subject to statistical analysis using analysis of variance and post hoc Tukey tests. The silver carboxylate coating demonstrated deep penetration into the epithelium at the level of the deep pilosebaceous glands in animal models. GFAAS testing demonstrated the extended elution profile of silver carboxylate over 96 hours, while 100% silver with no titanium dioxide-polydimethylsiloxane matrix fully eluted within 48 hours. 10x silver carboxylate demonstrated superior antimicrobial activity to antibiotics and other silver formulations and showed minimal cytotoxicity compared with other silver formulations. Current antimicrobial therapies in wound care and surgical antisepsis, such as chlorhexidine gluconate, have pitfalls including poor skin penetration and short duration of efficacy. The broad antimicrobial activity, extended elution, and deep skin penetration of this AgCar formulation show great promise for surgical site infection and wound care treatment. Novel technology to fight the growing threat of microbial resistance should be at the forefront of orthopaedic surgical site infection prevention and treatment.

Nanoclay particles as a stem cell adhesion factor in polyvinyl alcohol hydrogel‐based wound dressings

AbstractAs the primary goal in the wound care intervention is the promotion of rapid wound healing, researchers sought to find a remedy. In this progression course, nanocomposite‐based hydrogels have attracted the attention. Herein, we used a polyvinyl alcohol (PVA) hydrogel in combination with two forms of clay nanoparticles, namely unmodified montmorillonite (MONT) and modified (OMONT), to fabricate a nanocomposite‐based hydrogels and combat the lack of stem cells' adhesion to PVA, followed by seeding of adipose‐derived stem cells (ADSCs) on them. To investigate the characteristics of these constructs, corresponding tests were performed. The Young's modulus and elongation at break of PVA/5% OMONT were 3.7 ± 0.014 and 800 ± 35, respectively, which were higher than those of PVA/5% MONT (3 ± 0.03 and 320 ± 14). In addition, the hardness of the modified group (7.2 ± 0.07) was lower than the unmodified one (9.8 ± 0.07). The water vapor transmission rate (WVTR) in the OMONT group was 39 ± 0.28, which was lower than PVA/5% MONT (46 ± 4.24). Hence, ADSCs/PVA montmorillonite dressing may improve wound healing and provide a new way to employ stem cells, significantly impacting skin tissue engineering safely.Highlights Modified montmorillonite had higher stem cell binding. The lack of stem cells' adhesion to polyvinyl alcohol (PVA) was solved. Adipose‐derived stem cells/PVA montmorillonite dressing may improve wound healing. It is a novel promising approach for skin tissue engineering.

Exploring the potential of strontium oxide-enriched borate bioactive glass as a bone graft material: Comprehensive analysis of physical characteristics and gamma shielding properties

This study explores the physical, elastic, and radiation shielding properties of SrO–B2O3 -based bioactive glass systems. The interest in BAG has grown significantly in recent years due to their applications in biomedicine, including bone transplants, wound care, and dental treatments. Borate-based glass matrices have emerged as a promising alternative to silicate-based BAG, exhibiting faster conversion to hydroxyapatite (HA) in physiological fluids and promoting cell proliferation for bone healing. The procedure known as melt quenching is used to prepare the glasses. The effects of varying SrO content on the glass properties were evaluated to understand their potential applications in the field of radiation shielding. Experimental results were compared with theoretical models, including the Makishima, Mackenzie, and Rocherulle models, to determine the most appropriate model for analyzing the elastic properties. The Rocherulle model was found to be in better agreement with experimental results. It was observed that the elastic modulus increased with increasing SrO content, suggesting improved mechanical strength due to higher cross-link density in the glass network. Furthermore, the glasses exhibited low Poisson's ratio values, indicating increased resistance to deformation under stress. The Phy-X program was used to determine the mass attenuation coefficient (GMAC), which is the fundamental parameter for evaluating the interaction of radiation with shielding materials. The GMAC results increase as the amount of SrO is increased from 0 to 6 wt%. In addition, the findings demonstrated that the effective atomic number (Zeff) of the produced glasses rise when the amount of SrO is increased from 0 to 6 wt%. The comprehensive analysis of physical, elastic, and radiation shielding properties provides valuable insights into the optimization of glass systems for specific applications in industries that require mechanical strength and radiation protection.

Impact of Nursing Interventions on Patient Outcomes: A Comprehensive Analysis

This research explores the influence of specific nursing interventions on patient outcomes and satisfaction, such as medication management, patient education, and wound care. Employing a mixed-methods approach, the study combines quantitative analyses of surveys and medical records with qualitative insights gathered from interviews and focus group discussions involving healthcare professionals. The findings demonstrate a positive correlation between medication adherence and improvements in health, underscoring the importance of well-structured medication management .Additionally, the study identified variations in satisfaction levels based on different education levels, underscoring the necessity for tailored patient education strategies. Healthcare professionals, providing their perspectives, express positivity regarding wound care interventions and stress the practical value of ongoing training and resources in this field. These results contribute significantly to existing knowledge, offering nuanced insights into the specific impacts of nursing interventions. The study provides evidence-based recommendations for practitioners and policymakers to enhance patient care strategies.